Information on EC 6.5.1.1 - DNA ligase (ATP)

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The enzyme appears in viruses and cellular organisms

EC NUMBER
COMMENTARY hide
6.5.1.1
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RECOMMENDED NAME
GeneOntology No.
DNA ligase (ATP)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m = AMP + diphosphate + (deoxyribonucleotide)n+m
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
esterification
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phosphodiester
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SYSTEMATIC NAME
IUBMB Comments
Poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)
Catalyses the formation of a phosphodiester at the site of a single-strand break in duplex DNA. RNA can also act as substrate, to some extent. cf. EC 6.5.1.2, DNA ligase (NAD+), EC 6.5.1.6, DNA ligase (ATP or NAD+), and EC 6.5.1.7, DNA ligase (ATP, ADP or GTP).
CAS REGISTRY NUMBER
COMMENTARY hide
9015-85-4
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
the ApeLig gene is originally annotated as a protein of 619 amino acids, with a calculated mass of 69196.2 Da. Later it was reannotated as a protein of 602 amino acids (67747.6 Da), in which 17 amino acids are truncated from the N-terminus of the originally annotated protein. The UniProt-number refers to the 602 amino acid protein
SwissProt
Manually annotated by BRENDA team
Aeropyrum pernix DSM 11879
the ApeLig gene is originally annotated as a protein of 619 amino acids, with a calculated mass of 69196.2 Da. Later it was reannotated as a protein of 602 amino acids (67747.6 Da), in which 17 amino acids are truncated from the N-terminus of the originally annotated protein. The UniProt-number refers to the 602 amino acid protein
SwissProt
Manually annotated by BRENDA team
axolotl
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Manually annotated by BRENDA team
Arthrobacter chlorophenolicus A6
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
ligase I and II
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-
Manually annotated by BRENDA team
strain Ellin428
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-
Manually annotated by BRENDA team
strain Ellin428
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-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain AX4
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-
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
Enterobacteria phage
-
-
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Manually annotated by BRENDA team
Erwinia phage
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-
-
Manually annotated by BRENDA team
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-
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Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
strain YT DSM12658
UniProt
Manually annotated by BRENDA team
strain YT DSM12658
UniProt
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
Lymantria dispar multicapsid nucleopolyhedrovirus
most probably a type III DNA ligase
SwissProt
Manually annotated by BRENDA team
strains Guy11 and P2
Uniprot
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
Methanothermobacter thermautotrophicum
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SwissProt
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
Paramecium bursaria chlorella virus
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UniProt
Manually annotated by BRENDA team
Pleurodeles sp.
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
-
GenBank
Manually annotated by BRENDA team
strain 7
UniProt
Manually annotated by BRENDA team
strain 7
UniProt
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
acidophilic archaebacterium JP2 from geothermally active sites in Papua New Guinea
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Manually annotated by BRENDA team
Vibrio phage
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Manually annotated by BRENDA team
Xanthomonas phage
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
physiological function
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
5'-O-(3-Thio)adenosine triphosphate + (deoxyribonucleotide)n + (deoxyribonucleotide)m
5'-O-(3-Thio)adenosine monophosphate + diphosphate + (deoxyribonucleotide)n+m
show the reaction diagram
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-
-
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adenosine 5'-[alpha-thio]-triphosphate + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
show the reaction diagram
adenosine 5'-[beta,gamma-imido]-triphosphate + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
show the reaction diagram
adenosine 5'-[gamma-thio]-triphosphate + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
show the reaction diagram
ADP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + phosphate + (deoxyribonucleotide)n+m
show the reaction diagram
AMP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
show the reaction diagram
ATP + (2E,6E)-farnesyl diphosphate
adenosine 5'-((2E,6E)-farnesyl triphosphate) + diphosphate
show the reaction diagram
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-
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?
ATP + (2E,6E)-farnesyl triphosphate
adenosine 5'-((2E,6E)-farnesyl tetraphosphate) + diphosphate
show the reaction diagram
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-
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?
ATP + (deoxyribonucleotide)20 + (deoxyribonucleotide)20
AMP + diphosphate + (deoxyribonucleotide)40
show the reaction diagram
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sealing of a single nick in a 20mer DNA duplex, ADL is specific for nicked DNA and is not able to catalyze blunt end joining
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?
ATP + (deoxyribonucleotide)30 + (deoxyribonucleotide)40
AMP + diphosphate + (deoxyribonucleotide)70
show the reaction diagram
ligTK displays little but significant ativity with NAD+
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?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
show the reaction diagram
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + diphosphate + (deoxyribonucleotide)m+n
show the reaction diagram
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + diphosphate + (deoxyribonucleotide)n+m
show the reaction diagram
ATP + (single-stranded DNA splinted by RNA)m + (single-stranded DNA splinted by RNA)n
AMP + diphosphate + (single-stranded DNA splinted by RNA)m+n
show the reaction diagram
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-
-
?
ATP + ADP
P1-(5'-adenosyl),P3-(5'-adenosyl)triphosphate + diphosphate
show the reaction diagram
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?
ATP + CDP
P1-(5'-adenosyl),P3-(5'-cytidyl)triphosphate + diphosphate
show the reaction diagram
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?
ATP + clodronate
adenosine 5'-triphosphate derivative of clodronate + diphosphate
show the reaction diagram
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?
ATP + CTP
P1-(5'-adenosyl),P4-(5'-cytidyl)tetraphosphate + diphosphate
show the reaction diagram
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?
ATP + dCTP
P1-(5'-adenosyl),P4-[5'-(2'-deoxycytidyl)]tetraphosphate + diphosphate
show the reaction diagram
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?
ATP + dGTP
P1-(5'-adenosyl),P4-[5'-(2'-deoxyguanosyl)]tetraphosphate + diphosphate
show the reaction diagram
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-
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?
ATP + dimethylallyl diphosphate
adenosine 5'-dimethylallyltriphosphate + diphosphate
show the reaction diagram
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?
ATP + DNA substrate S4
AMP + diphosphate + ?
show the reaction diagram
ATP + dTTP
P1-(5'-adenosyl),P4-(5'-thymidyl)tetraphosphate + diphosphate
show the reaction diagram
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?
ATP + etidronate
adenosine 5'-triphosphate derivative of etidronate + diphosphate
show the reaction diagram
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?
ATP + GDP
P1-(5'-adenosyl),P3-(5'-guanosyl)triphosphate + diphosphate
show the reaction diagram
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?
ATP + geranyl diphosphate
adenosine 5'-geranyl triphosphate + diphosphate
show the reaction diagram
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-
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?
ATP + geranyl triphosphate
adenosine 5'-geranyl tetraphosphate + diphosphate
show the reaction diagram
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?
ATP + GTP
P1-(5'-adenosyl),P4-(5'-guanosyl)tetraphosphate + diphosphate
show the reaction diagram
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-
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?
ATP + isopentenyl diphosphate
adenosine 5'-isopentenyl triphosphate + diphosphate
show the reaction diagram
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?
ATP + isopentenyl triphosphate
adenosine 5'-isopentenyl tetraphosphate + diphosphate
show the reaction diagram
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?
ATP + methylenebisphosphonate
adenosine 5'-triphosphate derivative of methylenebisphosphonate + diphosphate
show the reaction diagram
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-
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?
ATP + tripolyphosphate
adenosine 5'-triphosphate derivative of tripolyphosphate + diphosphate
show the reaction diagram
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-
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?
ATP + UTP
P1-(5'-adenosyl),P4-(5'-uridinyl)tetraphosphate + diphosphate
show the reaction diagram
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-
-
?
ATP + XDP
P1-(5'-adenosyl),P4-(5'-xanthosyl)tetraphosphate + diphosphate
show the reaction diagram
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-
-
?
ATP + XTP
P1-(5'-adenosyl),P4-(5'-xanthosyl)tetraphosphate + diphosphate
show the reaction diagram
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-
-
?
ATPalphaS + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
show the reaction diagram
-
DNA ligase II can use ATPalphaS much more efficiently than DNA ligase I
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dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
dAMP + diphosphate + (deoxyribonucleotide)m+n
show the reaction diagram
dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
dAMP + diphosphate + (deoxyribonucleotide)n+m
show the reaction diagram
additional information
?
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
ATP + (deoxyribonucleotide)20 + (deoxyribonucleotide)20
AMP + diphosphate + (deoxyribonucleotide)40
show the reaction diagram
-
sealing of a single nick in a 20mer DNA duplex, ADL is specific for nicked DNA and is not able to catalyze blunt end joining
-
?
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
?
show the reaction diagram
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + diphosphate + (deoxyribonucleotide)m+n
show the reaction diagram
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
AMP + diphosphate + (deoxyribonucleotide)n+m
show the reaction diagram
dATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
dAMP + diphosphate + (deoxyribonucleotide)m+n
show the reaction diagram
-
-
-
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?
additional information
?
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