Literature summary for 6.5.1.1 extracted from

Sillero, M.A.; de Diego, A.; Tavares, J.E.; Silva, J.A.; Perez-Zuniga, F.J.; Sillero, A.
Synthesis of ATP derivatives of compounds of the mevalonate pathway (isopentenyl di- and triphosphate; geranyl di- and triphosphate, farnesyl di- and triphosphate, and dimethylallyl diphosphate) catalyzed by T4 RNA ligase, T4 DNA ligase and other ligases (2009), Biochem. Pharmacol., 78, 335-343.

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KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.05	-	farnesyl diphosphate	-	Tequatrovirus T4
0.15	-	(2E,6E)-farnesyl triphosphate	-	Tequatrovirus T4
0.21	-	geranyl diphosphate	-	Tequatrovirus T4
0.31	-	geranyl triphosphate	-	Tequatrovirus T4
0.63	-	isopentenyl triphosphate	-	Tequatrovirus T4
2.3	-	isopentenyl diphosphate	-	Tequatrovirus T4
4	-	dimethylallyl diphosphate	-	Tequatrovirus T4

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (2E,6E)-farnesyl diphosphate	-	Tequatrovirus T4	adenosine 5'-((2E,6E)-farnesyl triphosphate) + diphosphate	-	?
ATP + (2E,6E)-farnesyl triphosphate	-	Tequatrovirus T4	adenosine 5'-((2E,6E)-farnesyl tetraphosphate) + diphosphate	-	?
ATP + dimethylallyl diphosphate	-	Tequatrovirus T4	adenosine 5'-dimethylallyltriphosphate + diphosphate	-	?
ATP + geranyl diphosphate	-	Tequatrovirus T4	adenosine 5'-geranyl triphosphate + diphosphate	-	?
ATP + geranyl triphosphate	-	Tequatrovirus T4	adenosine 5'-geranyl tetraphosphate + diphosphate	-	?
ATP + isopentenyl diphosphate	-	Tequatrovirus T4	adenosine 5'-isopentenyl triphosphate + diphosphate	-	?
ATP + isopentenyl triphosphate	-	Tequatrovirus T4	adenosine 5'-isopentenyl tetraphosphate + diphosphate	-	?
ATP + tripolyphosphate	-	Tequatrovirus T4	adenosine 5'-triphosphate derivative of tripolyphosphate + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
T4 DNA ligase	-	Tequatrovirus T4

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.0008	-	geranyl diphosphate	-	Tequatrovirus T4
0.0028	-	farnesyl diphosphate	-	Tequatrovirus T4
0.0316	-	isopentenyl diphosphate	-	Tequatrovirus T4
0.0319	-	geranyl triphosphate	-	Tequatrovirus T4
0.0349	-	(2E,6E)-farnesyl triphosphate	-	Tequatrovirus T4
0.0492	-	dimethylallyl diphosphate	-	Tequatrovirus T4
0.0729	-	isopentenyl triphosphate	-	Tequatrovirus T4

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Tequatrovirus T4

kcat/KM [mM/s]

kcat/KM Value [1/mMs^-1]	kcat/KM Value Maximum [1/mMs^-1]	Substrate	Comment	Organism	Structure
0.0038	-	geranyl diphosphate	-	Tequatrovirus T4
0.0123	-	dimethylallyl diphosphate	-	Tequatrovirus T4
0.0138	-	isopentenyl diphosphate	-	Tequatrovirus T4
0.056	-	farnesyl diphosphate	-	Tequatrovirus T4
0.103	-	geranyl triphosphate	-	Tequatrovirus T4
0.116	-	isopentenyl triphosphate	-	Tequatrovirus T4
0.232	-	farnesyl triphosphate	-	Tequatrovirus T4

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Release 2023.1 (January 2023)