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Literature summary for 6.5.1.1 extracted from

  • Wang, Y.; Lamarche, B.J.; Tsai, M.D.
    Human DNA ligase IV and the ligase IV/XRCC4 complex: analysis of nick ligation fidelity (2007), Biochemistry, 46, 4962-4976.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
Escherichia coli-based coexpression system provides relatively high yields of the ligase IV/XRCC4 complex Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens ligase IV/XRCC4 is the sole DNA ligase involved in the repair of double strand breaks via the non-homologous end joining pathway. Analogous to most other DNA ligases, ligase IV/XRCC4 is fairly intolerant of nicks containing mismatched base pairs AMP + diphosphate + (deoxyribonucleotide)n+m
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Organism

Organism UniProt Comment Textmining
Homo sapiens P49917
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-

Purification (Commentary)

Purification (Comment) Organism
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Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
hippocampus
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Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m ligase IV/XRCC4 is the sole DNA ligase involved in the repair of double strand breaks via the non-homologous end joining pathway. Analogous to most other DNA ligases, ligase IV/XRCC4 is fairly intolerant of nicks containing mismatched base pairs Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
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Synonyms

Synonyms Comment Organism
DNA ligase 4
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Homo sapiens
DNA ligase IV
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Homo sapiens