Literature summary for 6.5.1.1 extracted from

Vijayakumar, S.; Dziegielewska, B.; Levin, D.S.; Song, W.; Yin, J.; Yang, A.; Matsumoto, Y.; Bermudez, V.P.; Hurwitz, J.; Tomkinson, A.E.
Phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repair (2009), Mol. Cell. Biol., 29, 2042-2052.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli and in Sf9 insect cells	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
Replication factor C	LigI interacts with and is inhibited by replication factor C	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
phosphoprotein	phosphorylation of human DNA ligase I regulates its interaction with replication factor C and its participation in DNA replication and DNA repair	Homo sapiens

Purification (Commentary)

Purification (Comment)	Organism
Sepharose column chromatography, Source Q column chromatography, and Superdex 200 gel filtration	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
46BR.1G1 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m	-	Homo sapiens	AMP + diphosphate + (deoxyribonucleotide)n+m	-	?

Synonyms

Synonyms	Comment	Organism
DNA ligase I	-	Homo sapiens
LigI	-	Homo sapiens

Cofactor

Cofactor	Comment	Organism	Structure
ATP	-	Homo sapiens

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Release 2023.1 (January 2023)