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Literature summary for 6.5.1.1 extracted from

  • Ranalli, T.A.; Tom, S.; Bambara, R.A.
    AP endonuclease 1 coordinates flap endonuclease 1 and DNA ligase I activity in long patch base excision repair (2002), J. Biol. Chem., 277, 41715-41724.
    View publication on PubMed
Search for more literature for 6.5.1.1

Activating Compound

Activating Compound Comment Organism Structure
apurine/apyrimidinic endonuclease I stimulation of DNA ligase activity, inhibition if the DNA ligase I substrate has a tetrahydrofuran residue on the 5'-downstream primer of a nick, simulating a reduced abasic site Homo sapiens
proliferating cell nuclear antigen
-
 Homo sapiens
replication protein
-
 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
apurine/apyrimidinic endonuclease I inhibition if the DNA ligase I substrate has a tetrahydrofuran residue on the 5'-downstream primer of a nick, simulating a reduced abasic site Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m Homo sapiens
-
 AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant DNA ligase I Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
 Homo sapiens AMP + diphosphate + (deoxyribonucleotide)m+n
-
 ?

Synonyms

Synonyms Comment Organism
DNA ligase I
-
 Homo sapiens