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Literature summary for 6.5.1.1 extracted from

  • Pascal, J.M.; Tsodikov, O.V.; Hura, G.L.; Song, W.; Cotner, E.A.; Classen, S.; Tomkinson, A.E.; Tainer, J.A.; Ellenberger, T.
    A flexible interface between DNA ligase and PCNA supports conformational switching and efficient ligation of DNA (2006), Mol. Cell., 24, 279-291.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information the enzyme interacts with the proliferating cell nuclear antigen heterotrimer Saccharolobus solfataricus

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Saccharolobus solfataricus

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor diffusion, crystal structures in conjunction with solution structures of these proteins based on small-angle X-ray scattering. In the absence of nicked DNA, the Sulfolobus solfataricus DNA ligase has an open, extended conformation. When complexed with heterotrimeric proliferating cell nuclear antigen, the DNA ligase binds to the proliferating cell nuclear antigen 3 subunit and ligase retain an open, extended conformation Saccharolobus solfataricus

Organism

Organism UniProt Comment Textmining
Saccharolobus solfataricus Q980T8
-
-
Saccharolobus solfataricus P2 Q980T8
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharolobus solfataricus

Synonyms

Synonyms Comment Organism
ssLig
-
Saccharolobus solfataricus
SSO0189 locus name Saccharolobus solfataricus