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Literature summary for 6.5.1.1 extracted from
- The antibiotic monensin causes cell cycle disruption of Toxoplasma gondii mediated through the DNA repair enzyme TgMSH-1 (2011), Antimicrob. Agents Chemother., 55, 745-755.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Toxoplasma gondii | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Toxoplasma gondii | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MSH-1 | - |
Toxoplasma gondii |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | disruption of MSH-1 results directly in resistance to monensin, salinomycin, and methylnitrourea | Toxoplasma gondii |
| physiological function | monensin activates an MSH-1-dependent cell cycle checkpoint ultimately leading to the death of the parasite | Toxoplasma gondii |
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Release 2023.1 (January 2023)
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