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Literature summary for 6.5.1.1 extracted from

  • Lopez Castel, A.; Tomkinson, A.E.; Pearson, C.E.
    CTG/CAG repeat instability is modulated by the levels of human DNA ligase I and its interaction with proliferating cell nuclear antigen: a distinction between replication and slipped-DNA repair (2009), J. Biol. Chem., 284, 26631-26645.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
additional information LigI activity is strongly linked to proliferating cell nuclear antigen, the interaction between both factors is essential for the recruitment of LigI to replication foci and sites of DNA damage, replication efficiency is reduced on CTG/CAG templates with a defective LigI Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
46BRLigI cell
-
Homo sapiens
-
HeLa cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
Homo sapiens AMP + diphosphate + (deoxyribonucleotide)n+m
-
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Synonyms

Synonyms Comment Organism
DNA ligase I
-
Homo sapiens
LigI
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
ATP
-
Homo sapiens

General Information

General Information Comment Organism
malfunction Lig1-deficient 46BR.1G1 cells are hypomutable by DNA damage Homo sapiens
physiological function human DNA ligase I is considered the main replicative ligase and plays an important role in the joining of Okazaki fragments during lagging strand synthesis Homo sapiens