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Synonyms
mgl, rmetase, metase, methioninase, l-methioninase, methionine gamma-lyase, l-methionine gamma-lyase, methionine-gamma-lyase, cale6, l-methionase,
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L-methionine gamma-lyase 1
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L-methionine-alpha-deamino-gamma-mercaptomethane lyase
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
lyase, methionine
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methionine alpha,gamma-lyase
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methionine dethiomethylase
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EhMGL1
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EhMGL1
methionine gamma-lyase isoenzyme 1
EhMGL2
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EhMGL2
methionine gamma-lyase isoenzyme 2
fer1MgL2
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Fn1419
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L-methionase
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L-methioninase
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L-methioninase
Achromobacter starkeyi
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L-methionine gamma-lyase
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L-methionine gamma-lyase
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L-methionine gamma-lyase
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L-methionine gamma-lyase
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L-methionine gamma-lyase
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L-methionine gamma-lyase
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L-methionine gamma-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
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L-methionine-gamma-lyase
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L-methionine-gamma-lyase
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L-methionine-gamma-lyase
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L-methionine-gamma-lyase
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L-methionine-gamma-lyase
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L-methionine-gamma-lyase
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MegL
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METase
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methioninase
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methionine gamma-lyase
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methionine gamma-lyase
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methionine gamma-lyase
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methionine gamma-lyase
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methionine gamma-lyase
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methionine gamma-lyase
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methionine gamma-lyase
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methionine gamma-lyase
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methionine gamma-lyase
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methionine-gamma-lyase
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MGL
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sav7062
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YtjE
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L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
mechanism
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L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
mechanism
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L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
mechanism
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L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
cleavage of C-N bond in addition to C-S, C-Se and C-O bond at beta-position of amino acids by elimination and replacement reactions
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L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
cleavage of C-N bond in addition to C-S, C-Se and C-O bond at beta-position of amino acids by elimination and replacement reactions
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L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
rate determining stage of the enzymatic reaction is deamination of aminocrotonate, important contribution of the sulfur atom and methylene groups to the efficiency of binding of substrates and inhibitors
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L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
gamma-elimination reaction mechanism and intermediates, overview
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
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(+)-alliin + H2O
allicin + pyruvate + NH3
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?
(+)methiin + H2O
methanesulfenic acid + pyruvate + NH3
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?
(+)propiin + H2O
propane-1-sulfenic acid + pyruvate + NH3
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?
(+-)-alliin + H2O
allicin + pyruvate + NH3
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?
(+-)-butiin + H2O
butane-1-sulfenic acid + pyruvate + NH3
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?
(+-)-ethiin + H2O
ethanesulfenic acid + pyruvate + NH3
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?
(+-)methiin + H2O
methanesulfenic acid + pyruvate + NH3
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(+-)propiin + H2O
propane-1-sulfenic acid + pyruvate + NH3
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?
1-amino-3-(methylthio)propylphosphinic acid + H2O
1-oxopropylphosphinic acid + methanethiol + NH3
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?
2-amino-3-(N,N-dimethylamino)propionic acid
2-iminopropionic acid + ?
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C-N-bond cleavage
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?
alliin + H2O
allicin + pyruvic acid + NH3
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?
beta-chloro-L-alanine + H2O
?
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?
cystathionine + ?
?
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?
DL-2-amino-3-(N-hydroxyethylamino)-propionic acid
ethanolamine + NH3 + pyruvate
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DL-2-amino-3-(N-methylamino)propionic acid
methylamine + NH3 + pyruvate
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?
DL-ethionine + H2O
?
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?
DL-homocysteic acid + H2O
?
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DL-homocysteine + 2-mercaptoethanol
H2S + S-(beta-hydroxyethyl)-L-homocysteine
gamma-replacement reaction, wild-type enzyme
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?
DL-homocysteine + H2O
2-oxobutanoate + NH3 + H2S
DL-homocysteine + H2O
2-oxobutanoate + NH3 + hydrogen sulfide
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?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
DL-homoserine + H2O
NH3 + 2-oxobutanoate
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?
ethiin + H2O
ethanesulfenic acid + pyruvate + NH3
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homocysteine + alkanethiol
S-alkylhomocysteine
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corresponding
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L-1-amino-3-methylthiopropylphosphinic acid + H2O
methanethiol + NH3 + propanoylphosphinic acid
Arg374 and Ser339 are involved in the binding of carboxyl groups of the substrate, the hydroxyl of Tyr113 is a potential acceptor of a proton from the amino groups of the amino acid
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L-cystathionine + ?
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L-cysteine
2-oxopropanoate + NH3 + H2S
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L-cysteine + 2-mercaptoethanol
H2S + S-(beta-hydroxyethyl)-L-cysteine
beta-replacement reaction, wild-type enzyme and mutant C116H
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L-cysteine + H2O
sulfide + NH3 + pyruvate
L-cystine + H2O
?
assay at pH 8.0, 37°C
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L-ethionine + H2O
ethanethiol + NH3 + 2-oxobutanoate
L-Gly(vinyl) + H2O
?
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L-homocysteine
2-oxobutanoate + NH3 + hydrogen sulfide
L-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
L-homocysteine + H2O
sulfide + NH3 + 2-oxobutanoate
L-homoserine
NH3 + 2-oxobutanoate
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?
L-methionine
methanethiol + NH3 + 2-oxobutanoate
L-methionine + 2-butylthiol
S-2-butylhomocysteine
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L-methionine + 2-mercaptoethanol
methanethiol + S-(beta-hydroxyethyl)-L-homocysteine
gamma-replacement reaction, wild-type enzyme
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L-methionine + 2-propylthiol
S-2-propylhomocysteine
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L-methionine + H2O
methanethiol + NH3 + 2-oxobutanoate
L-methionine sulfone + H2O
? + NH3 + 2-oxobutanoate
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?
L-methionine sulfoxide
?
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?
L-methionine sulfoxide + H2O
?
L-selenodjenkolate
pyruvate + NH3 + H2Se + formaldehyde
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L-selenomethionine + H2O
?
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methiin + H2O
methanesulfenic acid + pyruvate + NH3
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O-acetyl-DL-homoserine + H2O
NH3 + 2-oxobutanoate + acetate
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O-acetyl-L-homoserine
?
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O-acetyl-L-homoserine + H2O
2-oxobutanoate + NH3 + acetate
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?
O-acetyl-L-homoserine + H2O
?
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?
O-acetyl-L-serine + H2O
2-oxopropanoate + NH3 + acetate
O-methyl-L-serine + H2O
?
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?
O-succinyl-L-homoserine + H2O
?
weak activity
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S-benzyl-L-cysteine + H2O
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S-benzyl-L-cysteine + H2O
thiobenzyl alcohol + NH3 + 2-oxopropanoate
S-butyl-L-cysteine + H2O
butanethiol + NH3 + 2-oxopropanoate
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?
S-ethyl-L-cysteine
?
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S-ethyl-L-cysteine + H2O
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S-ethyl-L-cysteine + H2O
ethanethiol + NH3 + 2-oxopropanoate
S-ethyl-L-cysteine + H2O
ethanethiol + NH3 + pyruvate
Arg374 and Ser339 are involved in the binding of carboxyl groups of the substrate, the hydroxyl of Tyr113 is a potential acceptor of a proton from the amino groups of the amino acid. Formation of external aldimine, conformational changes in the active center enable the Tyr58 hydroxyl group to occupy a position favorable for protonation of the leaving group
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?
S-ethyl-L-homocysteine + H2O
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S-ethyl-L-homocysteine + H2O
ethanethiol + NH3 + 2-oxobutanoate
S-methyl-L-cysteine
?
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?
S-methyl-L-cysteine + 2-mercaptoethanol
?
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S-methyl-L-cysteine + H2O
?
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S-methyl-L-cysteine + H2O
methanethiol + NH3 + 2-oxopropanoate
S-methyl-L-cysteine + H2O
pyruvate + NH3 + CH3SH
S-methylcysteine + H2O
?
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?
S-propyl-L-cysteine + H2O
propanethiol + NH3 + 2-oxopropanoate
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Se-methylselenocysteine
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selenoethionine + H2O
ethylselenol + NH3 + 2-oxobutanoate
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?
selenomethionine + H2O
methylselenol + NH3 + 2-oxobutanoate
trifluoromethionine + H2O
?
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trifluoromethionine + H2O
trifluoromethanethiol + NH3 + 2-oxobutanoate
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DL-homocysteine + H2O
2-oxobutanoate + NH3 + H2S
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?
DL-homocysteine + H2O
2-oxobutanoate + NH3 + H2S
112% of activity with L-methionine
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?
DL-homocysteine + H2O
2-oxobutanoate + NH3 + H2S
294% of EhMGL1 activity with L-methionine
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DL-homocysteine + H2O
?
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?
DL-homocysteine + H2O
?
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?
DL-homocysteine + H2O
?
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?
DL-homocysteine + H2O
?
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?
DL-homocysteine + H2O
?
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?
DL-homocysteine + H2O
?
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?
DL-homocysteine + H2O
?
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DL-homocysteine + H2O
?
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?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
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?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
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?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
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?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
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?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
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?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
highest substrate specificity for DL-homocysteine
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?
ethionine
?
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?
L-cystathionine + H2O
?
assay at pH 8.0, 37°C
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?
L-cystathionine + H2O
?
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?
L-cystathionine + H2O
?
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?
L-cysteine
?
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?
L-cysteine + H2O
?
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?
L-cysteine + H2O
?
assay at pH 8.0, 37°C
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?
L-cysteine + H2O
?
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?
L-cysteine + H2O
?
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?
L-cysteine + H2O
?
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?
L-cysteine + H2O
?
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?
L-cysteine + H2O
?
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?
L-cysteine + H2O
?
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?
L-cysteine + H2O
sulfide + NH3 + pyruvate
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?
L-cysteine + H2O
sulfide + NH3 + pyruvate
4.4.1.11 methionine gamma-lyase
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