Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
Synonyms
mgl, rmetase, metase, methioninase, l-methioninase, methionine gamma-lyase, l-methionine gamma-lyase, methionine-gamma-lyase, cale6, l-methionase,
more
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-methionine gamma-lyase 1
-
L-methionine-alpha-deamino-gamma-mercaptomethane lyase
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
lyase, methionine
-
-
-
-
methionine alpha,gamma-lyase
-
-
methionine dethiomethylase
-
-
-
-
EhMGL1

-
-
EhMGL1
methionine gamma-lyase isoenzyme 1
EhMGL2

-
-
EhMGL2
methionine gamma-lyase isoenzyme 2
fer1MgL2

-
-
Fn1419

-
L-methionase

-
-
L-methioninase

-
-
-
-
L-methioninase
Achromobacter starkeyi
-
-
L-methionine gamma-lyase

-
-
-
-
L-methionine gamma-lyase
-
-
L-methionine gamma-lyase
-
L-methionine gamma-lyase
-
-
L-methionine gamma-lyase
-
-
L-methionine gamma-lyase
-
-
L-methionine gamma-lyase
-
L-methionine-alpha-deamino-gamma-mercaptomethane lyase

-
-
L-methionine-alpha-deamino-gamma-mercaptomethane lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase

-
-
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-alpha-deamino-gamma-mercaptomethane-lyase
-
-
L-methionine-gamma-lyase

-
-
L-methionine-gamma-lyase
-
-
-
L-methionine-gamma-lyase
-
-
L-methionine-gamma-lyase
-
-
-
L-methionine-gamma-lyase
-
-
L-methionine-gamma-lyase
-
-
-
MegL

-
METase

-
-
methioninase

-
-
-
-
methionine gamma-lyase

-
-
-
-
methionine gamma-lyase
-
-
methionine gamma-lyase
-
-
methionine gamma-lyase
-
-
methionine gamma-lyase
-
-
methionine gamma-lyase
-
-
methionine gamma-lyase
-
-
methionine gamma-lyase
-
-
methionine gamma-lyase
-
-
methionine-gamma-lyase

-
MGL

-
sav7062

-
YtjE

-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate

mechanism
-
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
mechanism
-
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
mechanism
-
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
cleavage of C-N bond in addition to C-S, C-Se and C-O bond at beta-position of amino acids by elimination and replacement reactions
-
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
cleavage of C-N bond in addition to C-S, C-Se and C-O bond at beta-position of amino acids by elimination and replacement reactions
-
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
rate determining stage of the enzymatic reaction is deamination of aminocrotonate, important contribution of the sulfur atom and methylene groups to the efficiency of binding of substrates and inhibitors
-
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
gamma-elimination reaction mechanism and intermediates, overview
L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
-
-
-
-
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
Please wait a moment until the data is sorted. This message will disappear when the data is sorted.
(+)-alliin + H2O
allicin + pyruvate + NH3
-
-
-
?
(+)methiin + H2O
methanesulfenic acid + pyruvate + NH3
-
-
-
?
(+)propiin + H2O
propane-1-sulfenic acid + pyruvate + NH3
-
-
-
?
(+-)-alliin + H2O
allicin + pyruvate + NH3
-
-
-
?
(+-)-butiin + H2O
butane-1-sulfenic acid + pyruvate + NH3
-
-
-
?
(+-)-ethiin + H2O
ethanesulfenic acid + pyruvate + NH3
-
-
-
?
(+-)methiin + H2O
methanesulfenic acid + pyruvate + NH3
-
-
-
?
(+-)propiin + H2O
propane-1-sulfenic acid + pyruvate + NH3
-
-
-
?
1-amino-3-(methylthio)propylphosphinic acid + H2O
1-oxopropylphosphinic acid + methanethiol + NH3
-
-
-
?
2-amino-3-(N,N-dimethylamino)propionic acid
2-iminopropionic acid + ?
-
C-N-bond cleavage
-
?
alliin + H2O
allicin + pyruvic acid + NH3
-
-
-
?
beta-chloro-L-alanine + H2O
?
-
-
-
?
cystathionine + ?
?
-
-
-
-
?
DL-2-amino-3-(N-hydroxyethylamino)-propionic acid
ethanolamine + NH3 + pyruvate
-
-
-
?
DL-2-amino-3-(N-methylamino)propionic acid
methylamine + NH3 + pyruvate
-
-
-
?
DL-ethionine + H2O
?
-
-
-
-
?
DL-homocysteic acid + H2O
?
-
-
-
-
?
DL-homocysteine + 2-mercaptoethanol
H2S + S-(beta-hydroxyethyl)-L-homocysteine
gamma-replacement reaction, wild-type enzyme
-
-
?
DL-homocysteine + H2O
2-oxobutanoate + NH3 + H2S
DL-homocysteine + H2O
2-oxobutanoate + NH3 + hydrogen sulfide
-
-
-
?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
DL-homoserine + H2O
NH3 + 2-oxobutanoate
-
-
-
-
?
ethiin + H2O
ethanesulfenic acid + pyruvate + NH3
-
-
-
?
homocysteine + alkanethiol
S-alkylhomocysteine
-
-
corresponding
?
L-1-amino-3-methylthiopropylphosphinic acid + H2O
methanethiol + NH3 + propanoylphosphinic acid
Arg374 and Ser339 are involved in the binding of carboxyl groups of the substrate, the hydroxyl of Tyr113 is a potential acceptor of a proton from the amino groups of the amino acid
-
-
?
L-cystathionine + ?
?
-
-
-
-
?
L-cysteine
2-oxopropanoate + NH3 + H2S
-
-
-
-
?
L-cysteine + 2-mercaptoethanol
H2S + S-(beta-hydroxyethyl)-L-cysteine
beta-replacement reaction, wild-type enzyme and mutant C116H
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate
L-cystine + H2O
?
assay at pH 8.0, 37°C
-
-
?
L-ethionine + H2O
ethanethiol + NH3 + 2-oxobutanoate
L-Gly(vinyl) + H2O
?
-
-
-
-
?
L-homocysteine
2-oxobutanoate + NH3 + hydrogen sulfide
L-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
L-homocysteine + H2O
sulfide + NH3 + 2-oxobutanoate
L-homoserine
NH3 + 2-oxobutanoate
-
-
-
?
L-methionine
methanethiol + NH3 + 2-oxobutanoate
L-methionine + 2-butylthiol
S-2-butylhomocysteine
-
-
-
?
L-methionine + 2-mercaptoethanol
methanethiol + S-(beta-hydroxyethyl)-L-homocysteine
gamma-replacement reaction, wild-type enzyme
-
-
?
L-methionine + 2-propylthiol
S-2-propylhomocysteine
-
-
-
?
L-methionine + H2O
methanethiol + NH3 + 2-oxobutanoate
L-methionine sulfone + H2O
? + NH3 + 2-oxobutanoate
-
-
-
?
L-methionine sulfoxide
?
-
-
-
-
?
L-methionine sulfoxide + H2O
?
L-selenodjenkolate
pyruvate + NH3 + H2Se + formaldehyde
-
-
-
?
L-selenomethionine + H2O
?
-
-
-
-
?
methiin + H2O
methanesulfenic acid + pyruvate + NH3
-
-
-
?
O-acetyl-DL-homoserine + H2O
NH3 + 2-oxobutanoate + acetate
-
-
-
-
?
O-acetyl-L-homoserine
?
-
-
-
?
O-acetyl-L-homoserine + H2O
2-oxobutanoate + NH3 + acetate
-
-
-
?
O-acetyl-L-homoserine + H2O
?
-
-
-
-
?
O-acetyl-L-serine + H2O
2-oxopropanoate + NH3 + acetate
O-methyl-L-serine + H2O
?
-
-
-
-
?
O-succinyl-L-homoserine + H2O
?
weak activity
-
-
?
S-benzyl-L-cysteine + H2O
?
S-benzyl-L-cysteine + H2O
thiobenzyl alcohol + NH3 + 2-oxopropanoate
S-butyl-L-cysteine + H2O
butanethiol + NH3 + 2-oxopropanoate
-
-
-
?
S-ethyl-L-cysteine
?
-
-
-
?
S-ethyl-L-cysteine + H2O
?
S-ethyl-L-cysteine + H2O
ethanethiol + NH3 + 2-oxopropanoate
S-ethyl-L-cysteine + H2O
ethanethiol + NH3 + pyruvate
Arg374 and Ser339 are involved in the binding of carboxyl groups of the substrate, the hydroxyl of Tyr113 is a potential acceptor of a proton from the amino groups of the amino acid. Formation of external aldimine, conformational changes in the active center enable the Tyr58 hydroxyl group to occupy a position favorable for protonation of the leaving group
-
-
?
S-ethyl-L-homocysteine + H2O
?
S-ethyl-L-homocysteine + H2O
ethanethiol + NH3 + 2-oxobutanoate
S-methyl-L-cysteine
?
-
-
-
?
S-methyl-L-cysteine + 2-mercaptoethanol
?
-
-
-
?
S-methyl-L-cysteine + H2O
?
-
-
-
-
?
S-methyl-L-cysteine + H2O
methanethiol + NH3 + 2-oxopropanoate
S-methyl-L-cysteine + H2O
pyruvate + NH3 + CH3SH
S-methylcysteine + H2O
?
-
-
-
-
?
S-propyl-L-cysteine + H2O
propanethiol + NH3 + 2-oxopropanoate
-
-
-
?
Se-methylselenocysteine
?
selenoethionine + H2O
ethylselenol + NH3 + 2-oxobutanoate
-
-
-
?
selenomethionine + H2O
methylselenol + NH3 + 2-oxobutanoate
trifluoromethionine + H2O
?
-
-
-
-
?
trifluoromethionine + H2O
trifluoromethanethiol + NH3 + 2-oxobutanoate
-
-
-
?
DL-homocysteine + H2O

2-oxobutanoate + NH3 + H2S
-
-
-
-
?
DL-homocysteine + H2O
2-oxobutanoate + NH3 + H2S
112% of activity with L-methionine
-
?
DL-homocysteine + H2O
2-oxobutanoate + NH3 + H2S
294% of EhMGL1 activity with L-methionine
-
?
DL-homocysteine + H2O

?
-
-
-
-
?
DL-homocysteine + H2O
?
-
-
-
-
?
DL-homocysteine + H2O
?
-
-
-
-
?
DL-homocysteine + H2O
?
-
-
-
-
?
DL-homocysteine + H2O
?
-
-
-
-
?
DL-homocysteine + H2O
?
-
-
-
-
?
DL-homocysteine + H2O
?
-
-
-
-
?
DL-homocysteine + H2O
?
-
-
-
-
?
DL-homocysteine + H2O

hydrogen sulfide + NH3 + 2-oxobutanoate
-
-
-
-
?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
-
-
-
?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
-
-
-
?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
-
-
-
?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
-
-
-
?
DL-homocysteine + H2O
hydrogen sulfide + NH3 + 2-oxobutanoate
highest substrate specificity for DL-homocysteine
-
-
?
ethionine

?
-
-
-
?
L-cystathionine + H2O

?
assay at pH 8.0, 37°C
-
-
?
L-cystathionine + H2O
?
-
-
-
-
?
L-cystathionine + H2O
?
-
-
-
-
?
L-cysteine

?
-
-
-
?
L-cysteine + H2O

?
-
-
-
-
?
L-cysteine + H2O
?
assay at pH 8.0, 37°C
-
-
?
L-cysteine + H2O
?
-
-
-
-
?
L-cysteine + H2O
?
-
-
-
-
?
L-cysteine + H2O
?
-
-
-
-
?
L-cysteine + H2O
?
-
-
-
-
?
L-cysteine + H2O
?
-
-
-
-
?
L-cysteine + H2O
?
-
-
-
-
?
L-cysteine + H2O

sulfide + NH3 + pyruvate
-
-
-
?
L-cysteine + H2O
sulfide + NH3 + pyruvate