Ligand methanethiol

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Basic Ligand Information

Molecular Structure
Picture of methanethiol (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
CH4S
methanethiol
LSDPWZHWYPCBBB-UHFFFAOYSA-N
Synonyms:
CH3SH, H-S-CH3, methanthiol, methyl-mercaptan, methyl-mercaptane, methyl mercaptan, methylmercaptan, methyl mercaptane, methylthiol, thiomethanol


Show all pahtways known for Show all BRENDA pathways known for methanethiol

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (6 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
2 methanethiol + NAD+ = dimethyl disulfide + NADH + H+
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methanethiol + O2 + H2O = formaldehyde + H2S + H2O2
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S-adenosyl-L-methionine + methanethiol = S-adenosyl-L-homocysteine + dimethyl sulfide
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O-acetyl-L-homoserine + methanethiol = L-methionine + acetate
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In Vivo Product in Enzyme-catalyzed Reactions (5 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dimethylsulfide + coenzyme M = methyl-CoM + methanethiol
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-
3-(methylthio)acryloyl-CoA + 2 H2O = acetaldehyde + methanethiol + CoA + CO2
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L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate
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Substrate in Enzyme-catalyzed Reactions (23 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
methylmercaptan + NADPH + H+ + O2 = ? + NADP+ + H2O
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2 methanethiol + NAD+ = dimethyl disulfide + NADH + H+
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methanethiol + O2 + H2O = formaldehyde + H2S + H2O2
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S-adenosyl-L-methionine + methanethiol = S-adenosyl-L-homocysteine + dimethyl sulfide
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methylmercaptan + S-adenosyl-L-methionine = dimethylsulfide + S-adenosyl-L-homocysteine
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L-vinylglycine + methanethiol = methionine
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methanethiol + acetyl-CoA = methanethioacetate + coenzyme A
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L-Cys + methanethiol = ?
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3-chloro-D-alanine + methyl-mercaptane = S-methyl-D-cysteine
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3-chloro-L-alanine + methylmercaptan = S-methyl-L-cysteine + Cl-
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Product in Enzyme-catalyzed Reactions (46 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
dimethylsulfide + coenzyme M = methyl-CoM + methanethiol
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S-methyl hydroxy(phenyl)ethanethioate + H2O = methanethiol + hydroxy(phenyl)acetic acid
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methylthio-beta-D-galactoside + H2O = galactose + methanethiol
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gamma-thiomethyl glutamate + H2O = Glu + thiomethanol
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ametryn + H2O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H-S-CH3
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3-(methylthio)acryloyl-CoA + 2 H2O = acetaldehyde + methanethiol + CoA + CO2
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S-methyl-D-cysteine + H2O = methanethiol + pyruvate + NH3
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S-methyl-L-cysteine + H2O = methanethiol + NH3 + 2-oxopropanoate
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Inhibitor in Enzyme-catalyzed Reactions (3 results)

EC NUMBER
COMMENTARY
LITERATURE
ENZYME 3D STRUCTURE

3D Structure of Enzyme-Ligand-Complex (PDB) (9 results)

Enzyme Kinetic Parameters

KM Value (7 results)

EC NUMBER
KM VALUE [MM]
KM VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
0.24
-
-
100
-
pH 7.3, 30C, gamma-replacement reaction

Ki Value (2 results)

EC NUMBER
KI VALUE [MM]
KI VALUE MAXIMUM [MM]
COMMENTARY
LITERATURE
TABLE ID

References & Links

Links to other databases for methanethiol

ChEBI
PubChem
ChEBI
PubChem