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Literature summary for 4.4.1.11 extracted from

  • Sato, D.; Nozaki, T.
    Methionine gamma-lyase: the unique reaction mechanism, physiological roles, and therapeutic applications against infectious diseases and cancers (2009), IUBMB Life, 61, 1019-1028.
    View publication on PubMed

Application

Application Comment Organism
medicine utilization for the treatment of cancers Arabidopsis thaliana
medicine utilization for the treatment of cancers Entamoeba histolytica
medicine utilization for the treatment of cancers Pseudomonas putida
medicine utilization for the treatment of cancers Brevibacterium linens
medicine utilization for the treatment of cancers Fusobacterium nucleatum
medicine utilization for the treatment of cancers Porphyromonas gingivalis
medicine utilization for the treatment of cancers Prevotella denticola
medicine utilization for the treatment of cancers Trichomonas vaginalis

Crystallization (Commentary)

Crystallization (Comment) Organism
-
Arabidopsis thaliana
-
Entamoeba histolytica
-
Pseudomonas putida
-
Brevibacterium linens
-
Fusobacterium nucleatum
-
Porphyromonas gingivalis
-
Prevotella denticola
-
Trichomonas vaginalis

Protein Variants

Protein Variants Comment Organism
C116H increase of enzyme activity toward cysteine, decrease of enzyme activity toward methionine Pseudomonas putida

Inhibitors

Inhibitors Comment Organism Structure
myrsinoic acid B
-
Fusobacterium nucleatum
myrsinoic acid B
-
Porphyromonas gingivalis
myrsinoic acid B
-
Prevotella denticola

Organism

Organism UniProt Comment Textmining
Arabidopsis thaliana
-
-
-
Brevibacterium linens
-
-
-
Entamoeba histolytica
-
-
-
Fusobacterium nucleatum
-
-
-
Porphyromonas gingivalis
-
-
-
Prevotella denticola
-
-
-
Pseudomonas putida
-
-
-
Trichomonas vaginalis O15564
-
-
Trichomonas vaginalis O15565
-
-

Source Tissue

Source Tissue Comment Organism Textmining
seed
-
Arabidopsis thaliana
-

Synonyms

Synonyms Comment Organism
EhMGL1
-
Entamoeba histolytica
EhMGL2
-
Entamoeba histolytica
methionine gamma-lyase
-
Arabidopsis thaliana
methionine gamma-lyase
-
Entamoeba histolytica
methionine gamma-lyase
-
Pseudomonas putida
methionine gamma-lyase
-
Brevibacterium linens
methionine gamma-lyase
-
Fusobacterium nucleatum
methionine gamma-lyase
-
Porphyromonas gingivalis
methionine gamma-lyase
-
Prevotella denticola
methionine gamma-lyase
-
Trichomonas vaginalis
TvMGL1
-
Trichomonas vaginalis
TvMGL2
-
Trichomonas vaginalis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000389
-
-
Fusobacterium nucleatum myrsinoic acid B
0.0303
-
-
Prevotella denticola myrsinoic acid B
0.0824
-
-
Porphyromonas gingivalis myrsinoic acid B

Expression

Organism Comment Expression
Arabidopsis thaliana higher expression in imbibed seeds up
Brevibacterium linens upregulation under methionine-rich conditions up

General Information

General Information Comment Organism
physiological function involvled in pathogenicity of periodontal bacterium Porphyromonas gingivalis
physiological function isoleucine biosynthesis, sulfur storage, involved in the alternative reverse-transsulfuration pathway, important roe in the resumption process Arabidopsis thaliana