Ligand ammonia

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Basic Ligand Information

Molecular Structure
Picture of ammonia (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H3N
ammonia
QGZKDVFQNNGYKY-UHFFFAOYSA-N
Synonyms:
ammonium, NH3, NH4+

Show all pahtways known for Show all pathways known for ammonia

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (53 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl phosphate + ammonia + thioredoxin disulfide = glycine + phosphate + thioredoxin
show the reaction diagram
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glyoxylate + NH3 + NADH = glycine + H2O + NAD+
show the reaction diagram
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NH3 + 2-oxoglutarate + NADPH + H+ = L-glutamate + NADP+ + H2O
show the reaction diagram
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L-2-amino-6-oxoheptanedioate + NH3 + NADPH = meso-2,6-diaminoheptanedioate + H2O + NADP+
show the reaction diagram
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(indol-3-yl)pyruvate + NH3 + NADH + H+ = L-tryptophan + NAD+ + H2O
show the reaction diagram
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2-oxoglutarate + NH3 + NADH = L-glutamate + H2O + NAD+
show the reaction diagram
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phenylpyruvate + NH3 + NADH = L-phenylalanine + H2O + NAD+
show the reaction diagram
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D-kynurenine + NH3 + H2O2 = kynurenic acid + NH3 + H2O2
show the reaction diagram
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hydroxylamine + NH3 + cytochrome c-554 = NO2 + H2O + reduced cytochrome c-554
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ATP + NH3 + CO2 = ADP + carbamoyl phosphate
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adenylylsulfate + NH3 = adenosine 5'-phosphoramidate + sulfate
show the reaction diagram
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L-aspartic acid + NH3 = ?
show the reaction diagram
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D-fructose 6-phosphate + NH3 = alpha-D-glucosamine 6-phosphate + H2O
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fumarate + NH3 = L-aspartate
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trans-cinnamate + NH3 = L-phenylalanine
show the reaction diagram
ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine
show the reaction diagram
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ATP + diphthine-[translation elongation factor 2] + NH3 = AMP + diphosphate + diphthamide-[translation elongation factor 2]
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ATP + L-aspartate + NH3 = ADP + phosphate + L-asparagine
show the reaction diagram
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ATP + 4-methylene-L-glutamate + NH3 = ?
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ATP + ribose 5-phosphate + NH4+ = ?
show the reaction diagram
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ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine
show the reaction diagram
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In Vivo Product in Enzyme-catalyzed Reactions (662 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-phenylalanine + O2 + H2O = 3-phenylpyruvic acid + ammonia + H2O2
show the reaction diagram
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L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3
show the reaction diagram
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kanamycin B + 2-oxoglutarate + O2 = 2'-dehydrokanamycin A + succinate + NH3 + CO2
show the reaction diagram
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anthranilate + NADPH + O2 = 2,3-dihydroxybenzoate + NADP+ + NH3
show the reaction diagram
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12 reduced ferredoxin + 12 H+ + N2 + 40 ATP + 40 H2O = 12 oxidized ferredoxin + 3 H2 + 2 NH3 + 40 ADP + 40 phosphate
show the reaction diagram
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glycine + phosphate + thioredoxin = acetyl phosphate + ammonia + thioredoxin disulfide
show the reaction diagram
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L-erythro-3,5-diaminohexanoate + H2O + NAD+ = 5-amino-3-oxohexanoate + NH3 + NADH + H+
show the reaction diagram
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L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+
show the reaction diagram
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meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+
show the reaction diagram
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L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+
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L-valine + NAD(P)+ + H2O = 2-oxoisovalerate + NH3 + NAD(P)H
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glycine + ferricytochrome c = glyoxylate + ferrocytochrome c + NH3
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putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2
show the reaction diagram
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L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2
show the reaction diagram
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L-arginine + H2O + O2 = 5-guanidino-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
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ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2
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N-(4-aminobutyl)-L-glutamine + H2O + O2 = N-(4-oxobutyl)-L-glutamine + NH3 + H2O2
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L-glutamine + H2O = L-glutamate + NH3
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D-alanine + H2O + FAD = pyruvate + NH3 + FADH2
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6-hydroxy-L-nicotine + H2O + O2 = 6-hydroxy-N-methylmyosmine + NH3 + H2O2
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hydroxylamine + NADH = NH3 + NAD+ + H2O
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nitrite + NADH + H+ = ammonia + NAD+ + H2O
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NAD(P)H + nitrite + H+ = NAD(P)+ + NH3 + H2O
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hydrazine + H2O + ferricytochrome c = nitric oxide + ammonium + ferrocytochrome c
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hydroxylamine + ferrocytochrome c = NH3 + H2O + ferricytochrome c
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methylamine + L-glutamate = NH3 + N-methyl-L-glutamate
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methylamine + a [Co(I) methylamine-specific corrinoid protein] = a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
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L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3
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phosphoramidate + D-glucose = D-glucose 1-phosphate + NH3
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ADP + carbamoyl phosphate = ATP + NH3 + CO2
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D-amino acid amide + H2O = D-amino acid + ammonia
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L-asparagine + H2O = L-aspartate + NH3
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maleamate + H2O = maleate + NH3
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[prokaryotic ubiquitin-like protein]-L-glutamine + H2O = [prokaryotic ubiquitin-like protein]-L-glutamate + NH3
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N-terminal L-asparaginyl-[protein] + H2O = N-terminal L-aspartyl-[protein] + NH3
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N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3
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oxamate + H2O = oxalate + ammonia
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L-asparagine + H2O = L-aspartate + NH3
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5-aminopentanamide + H2O = 5-aminopentanoate + NH3
show the reaction diagram
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D-glutamine + H2O = D-glutamate + NH3
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alpha-ketoglutaramate + H2O = alpha-ketoglutarate + NH3
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N-carbamoylputrescine + H2O = putrescine + CO2 + NH3
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L-tryptophanamide + H2O = L-tryptophan + NH3
show the reaction diagram
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N-carbamoylsarcosine + H2O = sarcosine + CO2 + NH3
show the reaction diagram
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(S)-2-amino-3-(3-hydroxy-4-oxo-4H-pyridin-1-yl)propanoate + H2O = 3-hydroxy-4H-pyrid-4-one + pyruvate + NH3
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N-carbamoyl-D-p-hydroxyphenylglycine + H2O = D-p-hydroxyphenylglycine + NH3 + CO2
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oleamide + H2O = oleic acid + NH3
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1-carboxybiuret + H2O = 1,3-dicarboxyurea + NH3
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6-oxo-1,4,5,6-tetrahydronicotinate + H2O = 2-formylglutarate + NH3
show the reaction diagram
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agmatine + H2O = N-carbamoylputrescine + NH3
show the reaction diagram
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N-formimino-L-aspartic acid + H2O = N-formylaspartic acid + NH3
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N-formimidoyl-L-glutamate + H2O = formate + ammonium + glutamate
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ATP + H2O = ITP + NH3
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adenine + H2O = hypoxanthine + NH3
show the reaction diagram
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1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3
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creatinine + H2O = N-methylhydantoin + NH3
show the reaction diagram
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blasticidin S + H2O = deaminohydroxyblasticidin S + NH3
show the reaction diagram
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sepiapterin + H2O = xanthopterin-B2 + NH3
show the reaction diagram
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S-adenosyl-L-homocysteine + H2O = S-inosyl-L-homocysteine + NH3
show the reaction diagram
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guanine + H2O = xanthine + NH3
show the reaction diagram
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dCTP + H2O = dUMP + diphosphate + NH3
show the reaction diagram
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adenine37 in tRNAAla + H2O = hypoxanthine37 in tRNAAla + NH3
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cytosine8 in tRNA + H2O = uracil8 in tRNA + NH3
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cytosine in single-stranded DNA + H2O = uracil in single-stranded DNA + NH3
show the reaction diagram
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6-amino-6-deoxyfutalosine + H2O = futalosine + NH3
show the reaction diagram
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5'-deoxyadenosine + H2O = 5'-deoxyinosine + NH3
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ammelide + H2O = cyanuric acid + NH3
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AMP + H2O = IMP + NH3
show the reaction diagram
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adenosine diphosphate + H2O = inosine diphosphate + NH3
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4-aminoimidazole + H2O = formiminoglycine + NH3 + unidentified product
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3-cyano-L-alanine + H2O = L-aspartate + NH3
show the reaction diagram
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3,5-dibromo-4-hydroxybenzonitrile + H2O = 3,5-dibromo-4-hydroxybenzoic acid + NH3
show the reaction diagram
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2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3
show the reaction diagram
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5-nitroanthranilate + H2O = 5-nitrosalicylate + NH3
show the reaction diagram
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adenosine 5'-phosphoramidate + H2O = AMP + NH3
show the reaction diagram
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L-Dopa + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2
show the reaction diagram
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L-phenylalanine + O2 + H2O = phenylacetaldehyde + CO2 + NH3 + H2O2
show the reaction diagram
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5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine + reduced acceptor = 5-hydroxybenzimidazole + 5'-deoxyadenosine + L-methionine + formate + NH3 + phosphate + oxidized acceptor
show the reaction diagram
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octopamine = (4-hydroxyphenyl)acetaldehyde + NH3 + H2O
show the reaction diagram
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ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate
show the reaction diagram
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L-aspartate = fumarate + NH3
show the reaction diagram
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L-ornithine = L-proline + NH3
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2,3-diaminopropanoate + H2O = pyruvate + 2 NH3
show the reaction diagram
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L-threo-3-hydroxyaspartate = oxaloacetate + NH3
show the reaction diagram
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L-tryptophan = 3-indoleacrylate + ammonia
show the reaction diagram
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5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine
show the reaction diagram
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5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3
show the reaction diagram
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ethanolamine = acetaldehyde + NH3
show the reaction diagram
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D-cysteine + H2O = sulfide + NH3 + pyruvate
show the reaction diagram
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L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate
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L-cysteate + H2O = pyruvate + bisulfite + NH3
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L-cysteine + H2O = sulfide + NH3 + pyruvate
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beta-chloro-D-alanine + H2O = pyruvate + chloride + NH3
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O-ureido-D-serine + ATP + H2O = D-cycloserine + CO2 + ammonia + ADP + phosphate
show the reaction diagram
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Substrate in Enzyme-catalyzed Reactions (379 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ammonia + NADPH + H+ + O2 = ? + NADP+ + H2O
show the reaction diagram
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acetyl phosphate + ammonia + thioredoxin disulfide = glycine + phosphate + thioredoxin
show the reaction diagram
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(indol-3-yl)pyruvate + NH3 + NADH + H+ = L-tryptophan + NAD+ + H2O
show the reaction diagram
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5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+ = L-arginine + H2O + NAD(P)+
show the reaction diagram
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D-kynurenine + NH3 + H2O2 = kynurenic acid + NH3 + H2O2
show the reaction diagram
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pyruvate + NH3 + NADPH + H+ = L-alanine + NADP+
show the reaction diagram
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NO + NH4+ = N2O + ?
show the reaction diagram
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ammonia + H2O + oxidized cytochrome C552 = nitrite + reduced cytochrome C552
show the reaction diagram
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ammonium + oxidized ferredoxin + H2O = nitrite + reduced ferredoxin + H+
show the reaction diagram
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N-methyl-L-glutamate + ammonia = ?
show the reaction diagram
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N-gamma-L-glutamylcyclohexylamine + NH4+ = cyclohexylamine + glutamine
show the reaction diagram
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NH3 + 5-phospho-alpha-D-ribose 1-diphosphate + H2O = 5-phospho-beta-D-ribosylamine + diphosphate
show the reaction diagram
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ammonia + 5-phospho-alpha-D-ribose 1-diphosphate = phosphoribosyl amine + diphosphate
show the reaction diagram
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7-cyano-7-carbaguanine in tRNA + NH3 = 7-carboximidamide-guanine in tRNA
show the reaction diagram
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L-aspartic acid + NH3 = ?
show the reaction diagram
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crotonic acid + NH3 = crotonamide + H2O
show the reaction diagram
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allyl cyanide + NH3 = 3-butenoic acid + NH3
show the reaction diagram
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indole + pyruvate + NH4+ = L-Trp + H2O
show the reaction diagram
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Crotonyl pantetheine + NH3 = Aminobutanoylpantetheine
show the reaction diagram
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acetaldehyde + NH3 = ethanolamine
show the reaction diagram
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ATP + D-Ala + NH3 = ADP + phosphate + D-AlaNH2
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ATP + adenosylcobyrinic acid a,c-diamide + ammonia + H2O = ADP + phosphate + adenosylcobyric acid + ?
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2 ATP + cobyrinate + 2 ammonia + 2 H2O = 2 ADP + 2 phosphate + cobyrinate a,c-diamide
show the reaction diagram
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ATP + NH4+ + HCO3- = ADP + phosphate + carbamoyl phosphate
show the reaction diagram
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Product in Enzyme-catalyzed Reactions (3745 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3
show the reaction diagram
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kanamycin B + 2-oxoglutarate + O2 = 2'-dehydrokanamycin A + succinate + NH3 + CO2
show the reaction diagram
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2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurzitane + NADH = NO2- + N2O + formate + NH4+
show the reaction diagram
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