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BRENDA support

Ligand ammonia

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Basic Ligand Information

Molecular Structure
Picture of ammonia (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
H3N
ammonia
QGZKDVFQNNGYKY-UHFFFAOYSA-N
Synonyms:
ammonium, NH3, NH4+
Pathway Source
Pathways
MetaCyc
(Z)-phenylmethanethial S-oxide biosynthesis, 1,4-dihydroxy-6-naphthoate biosynthesis I, 1-methylpyrrolinium biosynthesis, 2-amino-3-carboxymuconate semialdehyde degradation to 2-hydroxypentadienoate, 2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA more


Show all pahtways known for Show all BRENDA pathways known for ammonia

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (65 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl phosphate + NH3 + thioredoxin disulfide + H2O = glycine + phosphate + thioredoxin
show the reaction diagram
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glyoxylate + NH3 + NADH = glycine + H2O + NAD+
show the reaction diagram
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NH3 + 2-oxoglutarate + NADPH + H+ = L-glutamate + NADP+ + H2O
show the reaction diagram
-
L-2-amino-6-oxoheptanedioate + NH3 + NADPH = meso-2,6-diaminoheptanedioate + H2O + NADP+
show the reaction diagram
-
(indol-3-yl)pyruvate + NH3 + NADH + H+ = L-tryptophan + NAD+ + H2O
show the reaction diagram
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2-oxoglutarate + NH3 + NADH = L-glutamate + H2O + NAD+
show the reaction diagram
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phenylpyruvate + NH3 + NADH = L-phenylalanine + H2O + NAD+
show the reaction diagram
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5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH = glycine + tetrahydrofolate + NAD+
show the reaction diagram
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2-oxoglutarate + NH3 + NAD(P)H + H+ = L-glutamate + H2O + NAD(P)+
show the reaction diagram
D-kynurenine + NH3 + H2O2 = kynurenic acid + NH3 + H2O2
show the reaction diagram
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IMP + NH3 + NADP+ = GMP + NADPH + H+
show the reaction diagram
-
hydroxylamine + NH3 + cytochrome c-554 = NO2 + H2O + reduced cytochrome c-554
show the reaction diagram
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ATP + NH3 + CO2 = ADP + carbamoyl phosphate
show the reaction diagram
-
adenylylsulfate + NH3 = adenosine 5'-phosphoramidate + sulfate
show the reaction diagram
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L-aspartic acid + NH3 = ?
show the reaction diagram
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D-fructose 6-phosphate + NH3 = alpha-D-glucosamine 6-phosphate + H2O
show the reaction diagram
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fumarate + NH3 = L-aspartate
show the reaction diagram
-
trans-cinnamate + NH3 = L-phenylalanine
show the reaction diagram
ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine
show the reaction diagram
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ATP + diphthine-[translation elongation factor 2] + NH3 = AMP + diphosphate + diphthamide-[translation elongation factor 2]
show the reaction diagram
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ATP + L-aspartate + NH3 = ADP + phosphate + L-asparagine
show the reaction diagram
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ATP + 4-methylene-L-glutamate + NH3 = ?
show the reaction diagram
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ATP + ribose 5-phosphate + NH4+ = ?
show the reaction diagram
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beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-O-P-Glu-L-Lys-D-Ala-D-Ala)-diphospho-ditrans,octacis-undecaprenol + NH3 = beta-D-GlcNAc-(1->4)-MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenol + phosphate
show the reaction diagram
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ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (718 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
kanamycin B + 2-oxoglutarate + O2 = 2'-dehydrokanamycin A + succinate + NH3 + CO2
show the reaction diagram
-
anthranilate + NADPH + O2 = 2,3-dihydroxybenzoate + NADP+ + NH3
show the reaction diagram
-
12 reduced ferredoxin + 12 H+ + N2 + 40 ATP + 40 H2O = 12 oxidized ferredoxin + 3 H2 + 2 NH3 + 40 ADP + 40 phosphate
show the reaction diagram
-
glycine + phosphate + thioredoxin = acetyl phosphate + NH3 + thioredoxin disulfide + H2O
show the reaction diagram
-
L-erythro-3,5-diaminohexanoate + H2O + NAD+ = 5-amino-3-oxohexanoate + NH3 + NADH + H+
show the reaction diagram
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L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+
show the reaction diagram
-
meso-2,6-diaminoheptanedioate + H2O + NADP+ = L-2-amino-6-oxoheptanedioate + NH3 + NADPH + H+
show the reaction diagram
-
L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+
show the reaction diagram
-
glycine + tetrahydrofolate + NAD+ = 5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH
show the reaction diagram
-
L-valine + NAD(P)+ + H2O = 2-oxoisovalerate + NH3 + NAD(P)H
show the reaction diagram
-
glycine + ferricytochrome c = glyoxylate + ferrocytochrome c + NH3
show the reaction diagram
-
putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2
show the reaction diagram
-
L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2
show the reaction diagram
-
L-arginine + H2O + O2 = 5-guanidino-2-oxopentanoate + NH3 + H2O2
show the reaction diagram
-
ethanolamine + H2O + O2 = glycolaldehyde + NH3 + H2O2
show the reaction diagram
-
N-(4-aminobutyl)-L-glutamine + H2O + O2 = N-(4-oxobutyl)-L-glutamine + NH3 + H2O2
show the reaction diagram
-
L-glutamine + H2O = L-glutamate + NH3
show the reaction diagram
-
D-alanine + H2O + FAD = pyruvate + NH3 + FADH2
show the reaction diagram
-
6-hydroxy-L-nicotine + H2O + O2 = 6-hydroxy-N-methylmyosmine + NH3 + H2O2
show the reaction diagram
-
hydroxylamine + NADH = NH3 + NAD+ + H2O
show the reaction diagram
-
NAD(P)H + nitrite + H+ = NAD(P)+ + NH3 + H2O
show the reaction diagram
-
hydrazine + H2O + ferricytochrome c = nitric oxide + ammonium + ferrocytochrome c
show the reaction diagram
-
hydroxylamine + ferrocytochrome c = NH3 + H2O + ferricytochrome c
show the reaction diagram
-
methylamine + L-glutamate = NH3 + N-methyl-L-glutamate
show the reaction diagram
-
methylamine + a [Co(I) methylamine-specific corrinoid protein] = a [methyl-Co(III) methylamine-specific corrinoid protein] + ammonia
show the reaction diagram
-
phosphoramidate + D-glucose = D-glucose 1-phosphate + NH3
show the reaction diagram
-
ADP + carbamoyl phosphate = ATP + NH3 + CO2
show the reaction diagram
-
D-amino acid amide + H2O = D-amino acid + ammonia
show the reaction diagram
-
L-asparagine + H2O = L-aspartate + NH3
show the reaction diagram
-
maleamate + H2O = maleate + NH3
show the reaction diagram
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[prokaryotic ubiquitin-like protein]-L-glutamine + H2O = [prokaryotic ubiquitin-like protein]-L-glutamate + NH3
show the reaction diagram
-
N-terminal L-asparaginyl-[protein] + H2O = N-terminal L-aspartyl-[protein] + NH3
show the reaction diagram
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N-terminal L-glutaminyl-[protein] + H2O = N-terminal L-glutamyl-[protein] + NH3
show the reaction diagram
-
oxamate + H2O = oxalate + ammonia
show the reaction diagram
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L-citrulline + H2O = L-ornithine + CO2 + NH3
show the reaction diagram
-
L-asparagine + H2O = L-aspartate + NH3
show the reaction diagram
-
5-aminopentanamide + H2O = 5-aminopentanoate + NH3
show the reaction diagram
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D-glutamine + H2O = D-glutamate + NH3
show the reaction diagram
-
alpha-ketoglutaramate + H2O = alpha-ketoglutarate + NH3
show the reaction diagram
-
N-carbamoylputrescine + H2O = putrescine + CO2 + NH3
show the reaction diagram
-
L-tryptophanamide + H2O = L-tryptophan + NH3
show the reaction diagram
-
N-carbamoylsarcosine + H2O = sarcosine + CO2 + NH3
show the reaction diagram
-
oleamide + H2O = oleic acid + NH3
show the reaction diagram
-
6-oxo-1,4,5,6-tetrahydronicotinate + H2O = 2-formylglutarate + NH3
show the reaction diagram
-
agmatine + H2O = N-carbamoylputrescine + NH3
show the reaction diagram
-
N-formimino-L-aspartic acid + H2O = N-formylaspartic acid + NH3
show the reaction diagram
-
ATP + H2O = ITP + NH3
show the reaction diagram
-
adenine + H2O = hypoxanthine + NH3
show the reaction diagram
-
1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3
show the reaction diagram
-
creatinine + H2O = N-methylhydantoin + NH3
show the reaction diagram
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blasticidin S + H2O = deaminohydroxyblasticidin S + NH3
show the reaction diagram
-
sepiapterin + H2O = xanthopterin-B2 + NH3
show the reaction diagram
-
guanine + H2O = xanthine + NH3
show the reaction diagram
-
dCTP + H2O = dUMP + diphosphate + NH3
show the reaction diagram
-
S-methyl-5'-thioadenosine + H2O = S-methyl-5'-thioinosine + NH3
show the reaction diagram
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adenine37 in tRNAAla + H2O = hypoxanthine37 in tRNAAla + NH3
show the reaction diagram
-
cytosine8 in tRNA + H2O = uracil8 in tRNA + NH3
show the reaction diagram
-
cytosine in single-stranded DNA + H2O = uracil in single-stranded DNA + NH3
show the reaction diagram
-
6-amino-6-deoxyfutalosine + H2O = futalosine + NH3
show the reaction diagram
-
5'-deoxyadenosine + H2O = 5'-deoxyinosine + NH3
show the reaction diagram
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ammelide + H2O = cyanuric acid + NH3
show the reaction diagram
-
AMP + H2O = IMP + NH3
show the reaction diagram
-
adenosine diphosphate + H2O = inosine diphosphate + NH3
show the reaction diagram
-
4-aminoimidazole + H2O = formiminoglycine + NH3 + unidentified product
show the reaction diagram
-
3-cyano-L-alanine + H2O = L-aspartate + NH3
show the reaction diagram
-
3,5-dibromo-4-hydroxybenzonitrile + H2O = 3,5-dibromo-4-hydroxybenzoic acid + NH3
show the reaction diagram
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2-aminomuconate + H2O = (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NH3
show the reaction diagram
-
5-nitroanthranilate + H2O = 5-nitrosalicylate + NH3
show the reaction diagram
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adenosine 5'-phosphoramidate + H2O = AMP + NH3
show the reaction diagram
-
phosphoramidate + H2O = NH4+ + phosphate
show the reaction diagram
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L-Dopa + O2 + H2O = 3,4-dihydroxyphenylacetaldehyde + CO2 + NH3 + H2O2
show the reaction diagram
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L-phenylalanine + O2 + H2O = phenylacetaldehyde + CO2 + NH3 + H2O2
show the reaction diagram
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5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + S-adenosyl-L-methionine + reduced acceptor = 5-hydroxybenzimidazole + 5'-deoxyadenosine + L-methionine + formate + NH3 + phosphate + oxidized acceptor
show the reaction diagram
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octopamine = (4-hydroxyphenyl)acetaldehyde + NH3 + H2O
show the reaction diagram
-
ethanolamine phosphate + H2O = acetaldehyde + NH3 + phosphate
show the reaction diagram
-
L-aspartate = fumarate + NH3
show the reaction diagram
-
L-ornithine = L-proline + NH3
show the reaction diagram
-
2,3-diaminopropanoate + H2O = pyruvate + 2 NH3
show the reaction diagram
-
L-threo-3-hydroxyaspartate = oxaloacetate + NH3
show the reaction diagram
-
L-tryptophan = 3-indoleacrylate + ammonia
show the reaction diagram
-
5-amino-5-(4-hydroxybenzyl)-6-(D-ribitylimino)-5,6-dihydrouracil + S-adenosyl-L-methionine = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + NH3 + L-methionine + 5'-deoxyadenosine
show the reaction diagram
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5-formimidoyltetrahydrofolate = 5,10-methenyltetrahydrofolate + NH3
show the reaction diagram
-
ethanolamine = acetaldehyde + NH3
show the reaction diagram
-
D-cysteine + H2O = sulfide + NH3 + pyruvate
show the reaction diagram
-
L-homocysteine + H2O = hydrogen sulfide + NH3 + 2-oxobutanoate
show the reaction diagram
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L-cysteate + H2O = pyruvate + bisulfite + NH3
show the reaction diagram
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L-cysteine + H2O = sulfide + NH3 + pyruvate
show the reaction diagram
-
beta-chloro-D-alanine + H2O = pyruvate + chloride + NH3
show the reaction diagram
-
O-ureido-D-serine + ATP + H2O = D-cycloserine + CO2 + ammonia + ADP + phosphate
show the reaction diagram
-
L-glutamine + H2O = L-glutamate + NH3
show the reaction diagram
-

Substrate in Enzyme-catalyzed Reactions (532 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
ammonia + NADPH + H+ + O2 = ? + NADP+ + H2O
show the reaction diagram
-
acetyl phosphate + NH3 + thioredoxin disulfide + H2O = glycine + phosphate + thioredoxin
show the reaction diagram
-
(indol-3-yl)pyruvate + NH3 + NADH + H+ = L-tryptophan + NAD+ + H2O
show the reaction diagram
-
5-guanidino-2-oxopentanoate + NH3 + NAD(P)H + H+ = L-arginine + H2O + NAD(P)+
show the reaction diagram
-
5,10-methylenetetrahydrofolate + NH3 + CO2 + NADH = glycine + tetrahydrofolate + NAD+
show the reaction diagram
-
D-kynurenine + NH3 + H2O2 = kynurenic acid + NH3 + H2O2
show the reaction diagram
-
2,3-dihydro-1H-inden-1-one + NH3 + H2O2 = 2,3-dihydro-1H-inden-1-amine + H2O + O2
show the reaction diagram
-
pyruvate + NH3 + NADPH + H+ = L-alanine + NADP+
show the reaction diagram
-
NO + NH4+ = N2O + ?
show the reaction diagram
-
ammonia + H2O + oxidized cytochrome C552 = nitrite + reduced cytochrome C552
show the reaction diagram
-
NH3 + H2O + oxidized ferredoxin = nitrite + reduced ferredoxin + H+
show the reaction diagram
-
ammonium + oxidized ferredoxin + H2O = nitrite + reduced ferredoxin + H+
show the reaction diagram
-
N-methyl-L-glutamate + ammonia = ?
show the reaction diagram
-
N-gamma-L-glutamylcyclohexylamine + NH4+ = cyclohexylamine + glutamine
show the reaction diagram
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NH3 + 5-phospho-alpha-D-ribose 1-diphosphate + H2O = 5-phospho-beta-D-ribosylamine + diphosphate
show the reaction diagram
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ammonia + 5-phospho-alpha-D-ribose 1-diphosphate = phosphoribosyl amine + diphosphate
show the reaction diagram
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