Literature summary for 4.4.1.11 extracted from

Kulikova, V.; Morozova, E.; Rodionov, A.; Koval, V.; Anufrieva, N.; Revtovich, S.; Demidkina, T.
Non-stereoselective decomposition of (+-)-S-alk(en)yl-l-cysteine sulfoxides to antibacterial thiosulfinates catalyzed by C115H mutant methionine gamma-lyase from Citrobacter freundii (2018), Biochimie, 151, 42-44 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Citrobacter freundii

Protein Variants

Protein Variants	Comment	Organism
C115H	mutant cleaves S-alk(en)yl-L-cysteine sulfoxides more effectively than the wild type, reaction of EC 4.4.1.4	Citrobacter freundii

Organism

Organism	UniProt	Comment	Textmining
Citrobacter freundii	Q84AR1	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(+)-alliin + H2O	-	Citrobacter freundii	allicin + pyruvate + NH3	-	?
(+)methiin + H2O	-	Citrobacter freundii	methanesulfenic acid + pyruvate + NH3	-	?
(+)propiin + H2O	-	Citrobacter freundii	propane-1-sulfenic acid + pyruvate + NH3	-	?
(+-)-alliin + H2O	-	Citrobacter freundii	allicin + pyruvate + NH3	-	?
(+-)-butiin + H2O	-	Citrobacter freundii	butane-1-sulfenic acid + pyruvate + NH3	-	?
(+-)-ethiin + H2O	-	Citrobacter freundii	ethanesulfenic acid + pyruvate + NH3	-	?
(+-)methiin + H2O	-	Citrobacter freundii	methanesulfenic acid + pyruvate + NH3	-	?
(+-)propiin + H2O	-	Citrobacter freundii	propane-1-sulfenic acid + pyruvate + NH3	-	?
additional information	enzyme additionally catalyzes the beta-elimination reaction of (+-)-S-alk(en)yl-L-cysteine sulfoxides to yield thiosulfinate, reaction of EC 4.4.1.4. It can decompose both diastereomers equally	Citrobacter freundii	?	-	?
S-butyl-L-cysteine + H2O	-	Citrobacter freundii	butanethiol + NH3 + 2-oxopropanoate	-	?
S-ethyl-L-cysteine + H2O	-	Citrobacter freundii	ethanethiol + NH3 + 2-oxopropanoate	-	?
S-methyl-L-cysteine + H2O	-	Citrobacter freundii	methanethiol + NH3 + 2-oxopropanoate	-	?
S-propyl-L-cysteine + H2O	-	Citrobacter freundii	propanethiol + NH3 + 2-oxopropanoate	-	?

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Release 2023.1 (January 2023)