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Literature summary for 4.4.1.11 extracted from

  • El-Sayed, A.S.
    Microbial L-methioninase: production, molecular characterization, and therapeutic applications (2010), Appl. Microbiol. Biotechnol., 86, 445-467.
    View publication on PubMed

Application

Application Comment Organism
medicine enzyme therapy against various types of methionine-dependent tumors Entamoeba histolytica
medicine enzyme therapy against various types of methionine-dependent tumors Lactococcus lactis
medicine enzyme therapy against various types of methionine-dependent tumors Pseudomonas putida
medicine enzyme therapy against various types of methionine-dependent tumors Trichomonas vaginalis
medicine enzyme therapy against various types of methionine-dependent tumors Citrobacter freundii
medicine enzyme therapy against various types of methionine-dependent tumors Citrobacter intermedius
medicine enzyme therapy against various types of methionine-dependent tumors Clostridium sporogenes
medicine enzyme therapy against various types of methionine-dependent tumors Aeromonas sp.
medicine enzyme therapy against various types of methionine-dependent tumors Aspergillus sp.
medicine enzyme therapy against various types of methionine-dependent tumors Treponema denticola
medicine enzyme therapy against various types of methionine-dependent tumors Cladosporium cladosporioides
medicine enzyme therapy against various types of methionine-dependent tumors Aspergillus flavipes
medicine enzyme therapy against various types of methionine-dependent tumors Achromobacter starkeyi
medicine enzyme therapy against various types of methionine-dependent tumors Brevibacterium linens BL2

Crystallization (Commentary)

Crystallization (Comment) Organism
hanging-drop vapor-diffusion method Entamoeba histolytica
hanging-drop vapor-diffusion method Lactococcus lactis
hanging-drop vapor-diffusion method Pseudomonas putida
hanging-drop vapor-diffusion method Trichomonas vaginalis
hanging-drop vapor-diffusion method Citrobacter freundii
hanging-drop vapor-diffusion method Citrobacter intermedius
hanging-drop vapor-diffusion method Clostridium sporogenes
hanging-drop vapor-diffusion method Aeromonas sp.
hanging-drop vapor-diffusion method Aspergillus sp.
hanging-drop vapor-diffusion method Treponema denticola
hanging-drop vapor-diffusion method Cladosporium cladosporioides
hanging-drop vapor-diffusion method Aspergillus flavipes
hanging-drop vapor-diffusion method Brevibacterium linens BL2

Inhibitors

Inhibitors Comment Organism Structure
2-mercaptoethanol
-
Aspergillus flavipes
2-mercaptoethanol
-
Lactococcus lactis
3-Methyl-2-benzothiazolinone hydrazone
-
Lactococcus lactis
5-5'-dithiobis-(2-nitrobenzoic acid)
-
Brevibacterium linens BL2
5-5'-dithiobis-(2-nitrobenzoic acid)
-
Trichomonas vaginalis
aminoethyloxyvinylglycine
-
Achromobacter starkeyi
aminoethyloxyvinylglycine
-
Aeromonas sp.
aminoethyloxyvinylglycine
-
Aspergillus flavipes
aminoethyloxyvinylglycine
-
Aspergillus sp.
aminoethyloxyvinylglycine
-
Brevibacterium linens BL2
aminoethyloxyvinylglycine
-
Citrobacter freundii
aminoethyloxyvinylglycine
-
Citrobacter intermedius
aminoethyloxyvinylglycine
-
Cladosporium cladosporioides
aminoethyloxyvinylglycine
-
Clostridium sporogenes
aminoethyloxyvinylglycine
-
Entamoeba histolytica
aminoethyloxyvinylglycine
-
Lactococcus lactis
aminoethyloxyvinylglycine
-
Pseudomonas putida
aminoethyloxyvinylglycine
-
Treponema denticola
aminoethyloxyvinylglycine
-
Trichomonas vaginalis
DL-Penicillamine
-
Brevibacterium linens BL2
DL-Penicillamine
-
Trichomonas vaginalis
DL-propargylglycine
-
Brevibacterium linens BL2
DL-propargylglycine
-
Trichomonas vaginalis
DMSO
-
Aspergillus flavipes
DMSO
-
Lactococcus lactis
EDTA
-
Aspergillus flavipes
hydroxylamine
-
Brevibacterium linens BL2
hydroxylamine
-
Lactococcus lactis
hydroxylamine
-
Trichomonas vaginalis
iodoacetamide
-
Brevibacterium linens BL2
iodoacetamide
-
Trichomonas vaginalis
iodoacetate
-
Achromobacter starkeyi
iodoacetic acid
-
Aspergillus flavipes
iodoacetic acid
-
Lactococcus lactis
L-Cycloserine
-
Brevibacterium linens BL2
L-Cycloserine
-
Trichomonas vaginalis
p-chloromercuri-benzoic acid
-
Achromobacter starkeyi
p-chloromercuri-benzoic acid
-
Trichomonas vaginalis
p-chloromercuribenzoic acid
-
Brevibacterium linens BL2
propargylglycine
-
Achromobacter starkeyi
propargylglycine
-
Aeromonas sp.
propargylglycine
-
Aspergillus flavipes
propargylglycine
-
Aspergillus sp.
propargylglycine
-
Brevibacterium linens BL2
propargylglycine
-
Citrobacter freundii
propargylglycine
-
Citrobacter intermedius
propargylglycine
-
Cladosporium cladosporioides
propargylglycine
-
Clostridium sporogenes
propargylglycine
-
Entamoeba histolytica
propargylglycine
-
Lactococcus lactis
propargylglycine
-
Pseudomonas putida
propargylglycine
-
Treponema denticola
propargylglycine
-
Trichomonas vaginalis
Semicarbazide
-
Achromobacter starkeyi
Sodium arsenate
-
Achromobacter starkeyi
Sodium azide
-
Aspergillus flavipes

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
L-methionine values between 0.8 to 1.7, depending on publications Pseudomonas putida
0.0013
-
L-methionine
-
Aspergillus sp.
0.1
-
trifluoromethionine
-
Entamoeba histolytica
0.18
-
L-cysteine
-
Citrobacter freundii
0.2
-
L-ethionine
-
Pseudomonas putida
0.27
-
L-cystathionine
-
Lactococcus lactis
0.45
-
L-ethionine
-
Pseudomonas putida
0.46
-
L-cysteine
-
Lactococcus lactis
0.5
-
DL-homocysteine
-
Trichomonas vaginalis
0.5
-
L-ethionine
-
Trichomonas vaginalis
0.53
-
L-cysteine
-
Pseudomonas putida
0.55
-
L-methionine
-
Treponema denticola
0.56
-
L-ethionine
-
Citrobacter freundii
0.61
-
L-methionine
-
Entamoeba histolytica
0.61
-
S-methyl-L-cysteine
-
Citrobacter freundii
0.64
-
L-cysteine
-
Entamoeba histolytica
0.7
-
L-methionine
-
Citrobacter freundii
0.77
-
S-methylcysteine
-
Pseudomonas putida
0.87
-
L-methionine
-
Lactococcus lactis
1.1
-
DL-homocysteine
-
Citrobacter freundii
1.13
-
L-methionine
-
Citrobacter intermedius
1.33
-
L-methionine
-
Pseudomonas putida
1.8
-
DL-homocysteine
-
Pseudomonas putida
3.03
-
DL-homocysteine
-
Entamoeba histolytica
3.6
-
L-cysteine
-
Trichomonas vaginalis
4.3
-
L-methionine
-
Trichomonas vaginalis
6.43
-
L-homocysteine
-
Pseudomonas putida
30
-
L-homoserine
-
Pseudomonas putida
90
-
L-methionine
-
Clostridium sporogenes

Localization

Localization Comment Organism GeneOntology No. Textmining
intracellular
-
Entamoeba histolytica 5622
-
intracellular
-
Lactococcus lactis 5622
-
intracellular
-
Pseudomonas putida 5622
-
intracellular
-
Trichomonas vaginalis 5622
-
intracellular
-
Citrobacter freundii 5622
-
intracellular
-
Citrobacter intermedius 5622
-
intracellular
-
Clostridium sporogenes 5622
-
intracellular
-
Aeromonas sp. 5622
-
intracellular
-
Aspergillus sp. 5622
-
intracellular
-
Treponema denticola 5622
-
intracellular
-
Cladosporium cladosporioides 5622
-
intracellular
-
Aspergillus flavipes 5622
-
intracellular
-
Achromobacter starkeyi 5622
-
intracellular
-
Brevibacterium linens BL2 5622
-

Metals/Ions

Metals/Ions Comment Organism Structure
Cd2+ significant enzyme inhibition Aspergillus flavipes
Co2+ slightly stimulatory effect on the enzyme activity Aspergillus flavipes
Cu2+ slightly stimulatory effect on the enzyme activity Aspergillus flavipes
Li+ significant enzyme inhibition Aspergillus flavipes
Mg2+ slightly stimulatory effect on the enzyme activity Aspergillus flavipes
Mn2+ slightly stimulatory effect on the enzyme activity Aspergillus flavipes
Na+ significant enzyme inhibition Aspergillus flavipes
Ni2+ slightly stimulatory effect on the enzyme activity Aspergillus flavipes

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
37500
-
4 * 37500, SDS-PAGE Clostridium sporogenes
41000
-
4 * 41000, SDS-PAGE Aeromonas sp.
42600
-
4 * 42600, SDS-PAGE Pseudomonas putida
43000
-
4 * 43000, SDS-PAGE Entamoeba histolytica
43000
-
4 * 43000, SDS-PAGE Citrobacter freundii
43000
-
4 * 43000, SDS-PAGE Brevibacterium linens BL2
44000
-
4 * 44000, SDS-PAGE Trichomonas vaginalis
45000
-
4 * 45000, SDS-PAGE Pseudomonas putida
55000
-
4 * 55000, SDS-PAGE Lactococcus lactis

Organism

Organism UniProt Comment Textmining
Achromobacter starkeyi
-
-
-
Aeromonas sp.
-
-
-
Aspergillus flavipes
-
-
-
Aspergillus sp.
-
-
-
Aspergillus sp. Rs-1a
-
-
-
Brevibacterium linens BL2
-
-
-
Citrobacter freundii
-
-
-
Citrobacter intermedius
-
-
-
Cladosporium cladosporioides
-
-
-
Clostridium sporogenes
-
-
-
Entamoeba histolytica
-
-
-
Lactococcus lactis
-
-
-
no activity in mammalia
-
-
-
Pseudomonas putida
-
-
-
Treponema denticola
-
-
-
Trichomonas vaginalis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ion exchange and gel filtration chromatography Entamoeba histolytica
ion exchange and gel filtration chromatography Lactococcus lactis
ion exchange and gel filtration chromatography Pseudomonas putida
ion exchange and gel filtration chromatography Trichomonas vaginalis
ion exchange and gel filtration chromatography Citrobacter freundii
ion exchange and gel filtration chromatography Citrobacter intermedius
ion exchange and gel filtration chromatography Clostridium sporogenes
ion exchange and gel filtration chromatography Aeromonas sp.
ion exchange and gel filtration chromatography Aspergillus sp.
ion exchange and gel filtration chromatography Treponema denticola
ion exchange and gel filtration chromatography Cladosporium cladosporioides
ion exchange and gel filtration chromatography Aspergillus flavipes
ion exchange and gel filtration chromatography Brevibacterium linens BL2

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
value is 0.04 U/mg protein Lactococcus lactis
additional information
-
value is 0.26 U/mg protein Citrobacter intermedius
additional information
-
value is 0.44 U/mg protein Entamoeba histolytica
additional information
-
value is 1.8 U/mg protein Pseudomonas putida
additional information
-
value is 10 U/mg protein Citrobacter freundii
additional information
-
value is 228.9 U/mg protein Brevibacterium linens BL2
additional information
-
value is 3.17 U/mg protein Trichomonas vaginalis
additional information
-
value is 31.0 U/mg protein Aeromonas sp.
additional information
-
value is 36.6 U/mg protein Treponema denticola
additional information
-
value is 44.8 U/mg protein Aspergillus sp.
additional information
-
value is 45.3 U/mg protein Pseudomonas putida
additional information
-
value is 61 U/mg protein Aspergillus flavipes

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cystathionine + ?
-
Brevibacterium linens BL2 ?
-
?
DL-ethionine + H2O
-
Brevibacterium linens BL2 ?
-
?
DL-homocysteic acid + H2O
-
Trichomonas vaginalis ?
-
?
DL-homocysteine + H2O
-
Entamoeba histolytica ?
-
?
DL-homocysteine + H2O
-
Pseudomonas putida ?
-
?
DL-homocysteine + H2O
-
Trichomonas vaginalis ?
-
?
DL-homocysteine + H2O
-
Citrobacter freundii ?
-
?
DL-homocysteine + H2O
-
Clostridium sporogenes ?
-
?
DL-homocysteine + H2O
-
Aspergillus sp. ?
-
?
DL-homocysteine + H2O
-
Brevibacterium linens BL2 ?
-
?
DL-homocysteine + H2O
-
Aspergillus sp. Rs-1a ?
-
?
L-cystathionine + ?
-
Lactococcus lactis ?
-
?
L-cysteine + H2O
-
Entamoeba histolytica ?
-
?
L-cysteine + H2O
-
Lactococcus lactis ?
-
?
L-cysteine + H2O
-
Pseudomonas putida ?
-
?
L-cysteine + H2O
-
Trichomonas vaginalis ?
-
?
L-cysteine + H2O
-
Citrobacter freundii ?
-
?
L-cysteine + H2O
-
Clostridium sporogenes ?
-
?
L-cysteine + H2O
-
Brevibacterium linens BL2 ?
-
?
L-ethionine + H2O
-
Pseudomonas putida ?
-
?
L-ethionine + H2O
-
Trichomonas vaginalis ?
-
?
L-ethionine + H2O
-
Citrobacter freundii ?
-
?
L-ethionine + H2O
-
Clostridium sporogenes ?
-
?
L-ethionine + H2O
-
Aeromonas sp. ?
-
?
L-ethionine + H2O
-
Aspergillus sp. ?
-
?
L-ethionine + H2O
-
Aspergillus sp. Rs-1a ?
-
?
L-homocysteine + H2O
-
Pseudomonas putida ?
-
?
L-homocysteine + H2O
-
Aeromonas sp. ?
-
?
L-homoserine + H2O
-
Pseudomonas putida ?
-
?
L-homoserine + H2O
-
Aspergillus sp. ?
-
?
L-homoserine + H2O
-
Aspergillus sp. Rs-1a ?
-
?
L-methionine + H2O
-
Entamoeba histolytica ?
-
?
L-methionine + H2O
-
Lactococcus lactis ?
-
?
L-methionine + H2O
-
Pseudomonas putida ?
-
?
L-methionine + H2O
-
Trichomonas vaginalis ?
-
?
L-methionine + H2O
-
Citrobacter freundii ?
-
?
L-methionine + H2O
-
Citrobacter intermedius ?
-
?
L-methionine + H2O
-
Clostridium sporogenes ?
-
?
L-methionine + H2O
-
Aeromonas sp. ?
-
?
L-methionine + H2O
-
Aspergillus sp. ?
-
?
L-methionine + H2O
-
Treponema denticola ?
-
?
L-methionine + H2O
-
Cladosporium cladosporioides ?
-
?
L-methionine + H2O
-
Aspergillus flavipes ?
-
?
L-methionine + H2O
-
Brevibacterium linens BL2 ?
-
?
L-methionine + H2O
-
Aspergillus sp. Rs-1a ?
-
?
L-selenomethionine + H2O
-
Trichomonas vaginalis ?
-
?
O-acetyl-L-homoserine + H2O
-
Aeromonas sp. ?
-
?
S-methyl-L-cysteine + H2O
-
Citrobacter freundii ?
-
?
S-methylcysteine + H2O
-
Pseudomonas putida ?
-
?
trifluoromethionine + H2O
-
Entamoeba histolytica ?
-
?

Subunits

Subunits Comment Organism
tetramer
-
Citrobacter intermedius
tetramer
-
Aspergillus sp.
tetramer
-
Cladosporium cladosporioides
tetramer
-
Aspergillus flavipes
tetramer
-
Achromobacter starkeyi
tetramer 4 * 43000, SDS-PAGE Entamoeba histolytica
tetramer 4 * 43000, SDS-PAGE Citrobacter freundii
tetramer 4 * 43000, SDS-PAGE Brevibacterium linens BL2
tetramer 4 * 45000, SDS-PAGE Pseudomonas putida
tetramer 4 * 41000, SDS-PAGE Aeromonas sp.
tetramer 4 * 55000, SDS-PAGE Lactococcus lactis
tetramer 4 * 37500, SDS-PAGE Clostridium sporogenes
tetramer 4 * 44000, SDS-PAGE Trichomonas vaginalis
tetramer 4 * 42600, SDS-PAGE Pseudomonas putida
tetramer 4*43500, SDS-PAGE Treponema denticola

Synonyms

Synonyms Comment Organism
L-methioninase
-
Entamoeba histolytica
L-methioninase
-
Lactococcus lactis
L-methioninase
-
Pseudomonas putida
L-methioninase
-
Trichomonas vaginalis
L-methioninase
-
Citrobacter freundii
L-methioninase
-
Citrobacter intermedius
L-methioninase
-
Clostridium sporogenes
L-methioninase
-
Aeromonas sp.
L-methioninase
-
Aspergillus sp.
L-methioninase
-
Treponema denticola
L-methioninase
-
Cladosporium cladosporioides
L-methioninase
-
Aspergillus flavipes
L-methioninase
-
Achromobacter starkeyi
L-methioninase
-
Brevibacterium linens BL2

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
-
Brevibacterium linens BL2
30
-
-
Lactococcus lactis
30
-
-
Citrobacter freundii
30
-
-
Citrobacter intermedius
30
-
-
Cladosporium cladosporioides
30
-
-
Aspergillus flavipes
35
-
-
Aspergillus sp.
37
-
-
Entamoeba histolytica
37
-
-
Pseudomonas putida

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
additional information
-
L-methionine values between 25.3 to 48.6, depending on publications Pseudomonas putida
0.81
-
trifluoromethionine
-
Entamoeba histolytica
1.4
-
L-homoserine
-
Pseudomonas putida
1.59
-
L-cysteine
-
Entamoeba histolytica
1.82
-
L-methionine
-
Entamoeba histolytica
2.27
-
L-cysteine
-
Pseudomonas putida
2.3
-
L-cysteine
-
Citrobacter freundii
3.92
-
DL-homocysteine
-
Entamoeba histolytica
5.1
-
DL-homocysteine
-
Citrobacter freundii
5.9
-
S-methyl-L-cysteine
-
Citrobacter freundii
6.2
-
L-ethionine
-
Citrobacter freundii
6.5
-
L-methionine
-
Citrobacter freundii
33.4
-
L-ethionine
-
Pseudomonas putida
44.8
-
DL-homocysteine
-
Pseudomonas putida

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
-
Entamoeba histolytica
7.2
-
-
Pseudomonas putida
7.5
-
-
Brevibacterium linens BL2
8
-
-
Pseudomonas putida
8
-
-
Citrobacter freundii
8
-
-
Aeromonas sp.
8
-
-
Aspergillus sp.
8
-
-
Aspergillus flavipes
9
-
-
Cladosporium cladosporioides

pH Range

pH Minimum pH Maximum Comment Organism
7 8
-
Trichomonas vaginalis
7.5 8.5
-
Clostridium sporogenes

pH Stability

pH Stability pH Stability Maximum Comment Organism
5.6 8.2
-
Entamoeba histolytica
6 9
-
Pseudomonas putida
6 9
-
Aeromonas sp.
6 8
-
Brevibacterium linens BL2
6 10
-
Pseudomonas putida
6.5 9
-
Trichomonas vaginalis
8 9
-
Aspergillus sp.
8 9
-
Aspergillus flavipes

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
Entamoeba histolytica
pyridoxal 5'-phosphate
-
Lactococcus lactis
pyridoxal 5'-phosphate
-
Pseudomonas putida
pyridoxal 5'-phosphate
-
Trichomonas vaginalis
pyridoxal 5'-phosphate
-
Citrobacter freundii
pyridoxal 5'-phosphate
-
Citrobacter intermedius
pyridoxal 5'-phosphate
-
Clostridium sporogenes
pyridoxal 5'-phosphate
-
Aeromonas sp.
pyridoxal 5'-phosphate
-
Aspergillus sp.
pyridoxal 5'-phosphate
-
Treponema denticola
pyridoxal 5'-phosphate
-
Cladosporium cladosporioides
pyridoxal 5'-phosphate
-
Aspergillus flavipes
pyridoxal 5'-phosphate
-
Achromobacter starkeyi
pyridoxal 5'-phosphate
-
Brevibacterium linens BL2