Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 4.4.1.11 extracted from

  • Sun, X.; Yang, Z.; Li, S.; Tan, Y.; Zhang, N.; Wang, X.; Yagi, S.; Yoshioka, T.; Takimoto, A.; Mitsushima, K.; Suginaka, A.; Frenkel, E.P.; Hoffman, R.M.
    In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation (2003), Cancer Res., 63, 8377-8383.
    View publication on PubMed
Search for more literature for 4.4.1.11

Application

Application Comment Organism
medicine rMETase is an enzyme active in preclinical mouse models of human cancer Pseudomonas putida

General Stability

General Stability Organism
plasma half-life of polyethylene glycolylated rMETase in mice increases from 2 h for naked rMETase to 38 h for polyethylene glycolylated rMETase Pseudomonas putida

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine + H2O Pseudomonas putida
-
 methanethiol + NH3 + 2-oxobutanoate
-
 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas putida
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant rMETase Pseudomonas putida

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine + H2O
-
 Pseudomonas putida methanethiol + NH3 + 2-oxobutanoate
-
 ?

Synonyms

Synonyms Comment Organism
rMETase
-
 Pseudomonas putida

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Pseudomonas putida