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Information on EC 3.1.1.25 - 1,4-lactonase
for references in articles please use BRENDA:EC3.1.1.25
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EC Tree 3 Hydrolases
3.1 Acting on ester bonds
3.1.1 Carboxylic-ester hydrolases
3.1.1.25 1,4-lactonase
IUBMB Comments
The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It does not hydrolyse simple aliphatic esters, acetylcholine, sugar lactones or substituted aliphatic lactones, e.g. 3-hydroxy-4-butyrolactone; requires Ca2+.
The enzyme appears in viruses and cellular organisms
- 3.1.1.25
-
quorum
- homoserine
-
n-acyl
-
quorum-sensing
- solfataricus
-
ahl-degrading
-
n-acylhomoserine
-
quorum-quenching
-
phosphotriesterase-like
- pectobacterium
- carotovorum
- phosphotriesterase
- metallo-beta-lactamase
-
hxhxdh
-
c6-hsl
-
bioscavengers
-
ahl-mediated
-
acyl-homoserine
- ahl-lactonase
- synthesis
- medicine
showSynonyms
ahl lactonase, ssopox, vmolac, levo-lactonase, vmut_2255, more
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
AHL lactonase
gamma-lactonase
-
-
-
-
lactonase
lactonase, gamma
-
-
-
-
levo-lactonase
Saci_2140
SacPox
SisLac
SSO2522
SsoPox
VmoLac
VMUT_2255
SisLac
the enzyme also shows activity of aryldialkylphosphatase (EC 3.1.8.1) and arylesterase (EC 3.1.1.2)
SisLac
the enzyme also shows activity of aryldialkylphosphatase (EC 3.1.8.1) and arylesterase (EC 3.1.1.2)
-
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
a 1,4-lactone + H2O = a 4-hydroxyacid
-
-
-
-
a 1,4-lactone + H2O = a 4-hydroxyacid
upon substrate binding, the zinc-bridging hydroxide anion is effectively protected from re-protonation by the plug-like function of the acyl tails whereupon the ring-opening reaction can proceed. Subsequent protonation of the product's alkoxide group can then be accomplished by the intramolecular proton transfer from the intermediate state's carboxylic acid group where the resulting carboxylate group better accommodates the still-neighboring zinc ion
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of carboxylic ester
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
MetaCyc
D-galactose degradation II
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SYSTEMATIC NAME
IUBMB Comments
1,4-lactone hydroxyacylhydrolase
The enzyme is specific for 1,4-lactones with 4-8 carbon atoms. It does not hydrolyse simple aliphatic esters, acetylcholine, sugar lactones or substituted aliphatic lactones, e.g. 3-hydroxy-4-butyrolactone; requires Ca2+.
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CAS REGISTRY NUMBER
COMMENTARY
37278-38-9
-
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
LITERATURE
COMMENTARY
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
(2S,4RS)-2-hydroxy-4-butyrolactone + H2O
(S)-2-hydroxy-4-phenylbutyrate
-
Substrates: -
Products: -
Products: -
?
(R)-alpha-hydroxy-gamma-butyrolactone + H2O
(R)-2-hydroxybutyric acid
Substrates: enzyme variant Q192: 0.88% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 3.95% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
(R)-dihydro-5-(hydroxymethyl)-2(3H)-furanone + H2O
?
Substrates: enzyme variant Q192: 1.23% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 3.29% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
(R)-gamma-valerolactone + H2O
4-hydroxypentanoic acid
-
Substrates: -
Products: -
Products: -
?
(S)-alpha-hydroxy-gamma-butyrolactone + H2O
(S)-2-hydroxybutyric acid
Substrates: enzyme variant Q192: 8.14% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 19.6% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
(S)-beta-hydroxy-gamma-butyrolactone + H2O
(S)-3-hydroxybutyric acid
Substrates: enzyme variant Q192: 0.6% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 0.76% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
(S)-dihydro-5-(hydroxymethyl)-2(3H)-furanone + H2O
?
Substrates: enzyme variant Q192: 0.78% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 1.12% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
2-bromobutyrolactone + H2O
?
Substrates: less than 1% activity compared to DL-pantoyl lactone
Products: -
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?
2-hydroxybutyrolactone + H2O
?
Substrates: 2450% activity compared to DL-pantoyl lactone
Products: -
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?
3-oxo-octanoyl-L-homoserine lactone + H2O
N-(3-oxooctanoyl)-L-homoserine
Substrates: -
Products: -
Products: -
?
4-(1-propenyloxymethyl)-1,3-dioxolan-2-one + H2O
?
Substrates: enzyme variant Q192: 2.23% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 2.52% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
4-butyrolactone + H2O
?
Substrates: less than 1% activity compared to DL-pantoyl lactone
Products: -
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?
4-methoxyphenyl acetate + H2O
4-methoxyphenol + acetate
Substrates: -
Products: -
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?
4-phenyl-2-hydroxyl-4-butyrolactone + H2O
?
Substrates: 22% activity compared to DL-pantoyl lactone
Products: -
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?
5-(thioethyl)butyrolactone + H2O
?
Substrates: the lactonase and the esterase activity of PON1 is mediated by the His115-His134 dyad
Products: -
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?
5-butyl-4-methyldihydro-2(3H)-furanone + H2O
4-hydroxy-3-methyl-octanoate
Substrates: i.e. whiskey lactone
Products: -
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?
5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid 1,5-lactone + H2O
5-hydroxy-(6E,8Z,11Z,14Z)-eicosatetraenoic acid
Substrates: -
Products: -
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?
5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid 1,5-lactone + H2O
5-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid
Substrates: -
Products: -
Products: -
?
5-thiobutyl butyrolactone + H2O
4-(butylsulfanyl)-4-hydroxybutanoic acid
-
Substrates: -
Products: -
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?
5-thiobutyl-butyro-1,4-lactone + H2O
?
-
Substrates: -
Products: -
Products: -
?
7-O-diethyl phosphoryl 3-cyano 4-methyl 7-hydroxycoumarin + H2O
?
Substrates: -
Products: -
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?
7-O-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin + H2O
(2Z)-2-cyano-3-[4-[(diethoxyphosphoryl)oxy]-2-hydroxyphenyl]but-2-enoic acid
-
Substrates: -
Products: -
Products: -
?
7-oxo-N-(2-oxotetrahydrofuran-3-yl)nonanamide + H2O
3-hydroxy-2-[(7-oxononanoyl)amino]propanoic acid
9-oxo-N-(2-oxotetrahydrofuran-3-yl)undecanamide + H2O
3-hydroxy-2-[(9-oxoundecanoyl)amino]propanoate
Substrates: -
Products: -
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?
9-oxo-N-(2-oxotetrahydrofuran-3-yl)undecanamide + H2O
3-hydroxy-2-[(9-oxoundecanoyl)amino]propanoic acid
Substrates: -
Products: -
Products: -
?
alpha-angelicalactone + H2O
4-hydroxy-pent-3-enoic acid
Substrates: -
Products: -
Products: -
?
alpha-angelicalactone + H2O
4-hydroxypent-3-enoic acid
Substrates: -
Products: -
Products: -
?
alpha-angelicalactone + H2O
?
Substrates: enzyme variant Q192: 19.9% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 14.8% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
alpha-bromo-gamma-butyrolactone + H2O
2-bromobutyric acid
Substrates: enzyme variant Q192: 47.2% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 40.8% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
alpha-hydroxy-beta,beta-dimethyl-gamma-butyrolactone + H2O
2,4-dihydroxy-3,3-dimethylbutanoate
-
Substrates: -
Products: -
Products: -
?
alpha-hydroxy-gamma-butyrolactone + H2O
2,4-dihydroxybutanoate
-
Substrates: -
Products: -
Products: -
?
beta-butyrolactone + H2O
3-hydroxybutanoate
-
Substrates: -
Products: -
Products: -
?
beta-hydroxy-gamma-butyrolactone + H2O
3,4-dihydroxybutanoate
-
Substrates: -
Products: -
Products: -
?
canrenone + H2O
?
Substrates: not hydrolyzed by PON1 (P27169 (UniProt)) and PON2 (Q15165 (UniProt))
Products: -
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?
delta-dodecalactone + H2O
5-hydroxydecanoate
Substrates: -
Products: -
Products: -
?
delta-dodecanolactone + H2O
5-hydroxydodecanoate
Substrates: -
Products: -
Products: -
?
delta-hexalactone + H2O
5-hydroxyhexanoic acid
Substrates: -
Products: -
Products: -
?
delta-tetradecanolactone + H2O
5-hydroxytetradecanoic acid
Substrates: -
Products: -
Products: -
?
delta-undecalactone + H2O
5-hydroxydecanoate
Substrates: -
Products: -
Products: -
?
delta-undecanolactone + H2O
5-hydroxyundecanoate
Substrates: -
Products: -
Products: -
?
delta-undecanolactone + H2O
5-hydroxyundecanoic acid
Substrates: -
Products: -
Products: -
?
DL-3-oxo-hexanoyl-homoserine lactone + H2O
DL-3-oxo-hexanoyl-homoserine
Substrates: -
Products: -
Products: -
?
DL-3-oxo-hexanoylhomoserine lactone + H2O
DL-3-oxo-hexanoylhomoserine
Substrates: -
Products: -
Products: -
?
DL-dodecanoyl-homoserine lactone + H2O
DL-dodecanoyl-homoserine
Substrates: -
Products: -
Products: -
?
DL-dodecanoylhomoserine lactone + H2O
DL-dodecanoylhomoserine
Substrates: -
Products: -
Products: -
?
DL-heptanoyl-homoserine lactone + H2O
DL-heptanoyl-homoserine
Substrates: -
Products: -
Products: -
?
DL-heptanoylhomoserine lactone + H2O
DL-heptanoylhomoserine
Substrates: -
Products: -
Products: -
?
DL-pantoyllactone + H2O
pantoic acid
Substrates: 100% activity
Products: -
Products: -
?
DL-tetradecanoyl-homoserine lactone + H2O
DL-tetradecanoyl-homoserine
Substrates: -
Products: -
Products: -
?
DL-tetradecanoylhomoserine lactone + H2O
DL-tetradecanoyl-homoserine
Substrates: -
Products: -
Products: -
?
DL-tetradecanoylhomoserine lactone + H2O
DL-tetradecanoylhomoserine
Substrates: -
Products: -
Products: -
?
dodecanoic-1,4-lactone + H2O
4-hydroxydodecanoate
Substrates: -
Products: -
Products: -
?
dodecanoic-1,5-lactone + H2O
5-hydroxydodecanoate
Substrates: -
Products: -
Products: -
?
dodecanoic-gamma-lactone + H2O
dodecanoate
Substrates: -
Products: -
Products: -
?
epsilon-caprolactone + H2O
6-hydroxyhexanoic acid
Substrates: enzyme variant Q192: 14.8% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 25.7% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
ethyl acetate + H2O
?
Substrates: less than 1% activity compared to DL-pantoyl lactone
Products: -
Products: -
?
gamma-(R)-caprolactone + H2O
4-hydroxyhexanoate
Substrates: slight preference but not an exclusive specificity for the (R)-enantiomers of capro- and valerolactone
Products: -
Products: -
?
gamma-(R)-valerolactone + H2O
4-hydroxypentanoate
Substrates: slight preference but not an exclusive specificity for the (R)-enantiomers of capro- and valerolactone
Products: -
Products: -
?
gamma-(S)-caprolactone + H2O
4-hydroxyhexanoate
Substrates: slight preference but not an exclusive specificity for the (R)-enantiomers of capro- and valerolactone
Products: -
Products: -
?
gamma-(S)-valerolactone + H2O
4-hydroxypentanoate
Substrates: slight preference but not an exclusive specificity for the (R)-enantiomers of capro- and valerolactone
Products: -
Products: -
?
gamma-butyrolactone + H2O
4-hydroxy-butyric acid
Substrates: -
Products: -
Products: -
?
gamma-butyrolactone + H2O
4-hydroxybutanoic acid
Substrates: -
Products: -
Products: -
?
gamma-dodecalactone + H2O
4-hydroxydodecanoate
Substrates: -
Products: -
Products: -
?
gamma-dodecanoic acid lactone + H2O
4-hydroxydodecanoic acid
Substrates: -
Products: -
Products: -
?
gamma-dodecanoic lactone + H2O
4-hydroxydodecanoic acid
Substrates: -
Products: -
Products: -
?
gamma-dodecanolactone + H2O
4-hydroxydodecanoate
Substrates: -
Products: -
Products: -
?
gamma-heptalactone + H2O
4-hydroxyheptanoate
Substrates: -
Products: -
Products: -
?
gamma-heptalactone + H2O
4-hydroxyheptanoic acid
Substrates: -
Products: -
Products: -
?
gamma-heptanolactone + H2O
4-hydroxyheptanoate
Substrates: -
Products: -
Products: -
?
gamma-heptanolide + H2O
4-hydroxyheptanoate
Substrates: -
Products: -
Products: -
?
gamma-heptanolide + H2O
4-hydroxyheptanoic acid
Substrates: -
Products: -
Products: -
?
gamma-hexalactone + H2O
4-hydroxyhexanoic acid
Substrates: -
Products: -
Products: -
?
gamma-nonanoic acid lactone + H2O
4-hydroxynonanoic acid
Substrates: -
Products: -
Products: -
?
gamma-octalactone + H2O
4-hydroxyoctanoic acid
Substrates: -
Products: -
Products: -
?
gamma-phenyl-gamma-butyrolactone + H2O
4-hydroxy-4-phenyl-butanoic acid
Substrates: -
Products: -
Products: -
?
gamma-phenyl-gamma-butyrolactone + H2O
4-hydroxy-4-phenylbutanoic acid
Substrates: -
Products: -
Products: -
?
gamma-undecalactone + H2O
4-hydroxyundecanoate
Substrates: -
Products: -
Products: -
?
gamma-undecanoic acid lactone + H2O
4-hydroxyundecanoic acid
Substrates: -
Products: -
Products: -
?
gamma-undecanoic lactone + H2O
4-hydroxyundecanoic acid
Substrates: -
Products: -
Products: -
?
gamma-undecanolactone + H2O
4-hydroxyundecanoate
Substrates: -
Products: -
Products: -
?
gamma-undecanolactone + H2O
4-hydroxyundecanoic acid
Substrates: -
Products: -
Products: -
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homocysteinthiolactone + H2O
(2S)-2-aminobutanethioic S-acid
Substrates: -
Products: -
Products: -
?
methyl 2-chloroacetate + H2O
?
Substrates: 11.6% activity compared to DL-pantoyl lactone
Products: -
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?
methyl 2-chloropropanoate + H2O
?
Substrates: 2.3% activity compared to DL-pantoyl lactone
Products: -
Products: -
?
methyl lactate + H2O
?
Substrates: less than 1% activity compared to DL-pantoyl lactone
Products: -
Products: -
?
methyl mandelate + H2O
?
Substrates: less than 1% activity compared to DL-pantoyl lactone
Products: -
Products: -
?
mevastatin + H2O
?
Substrates: activity with enzyme variant Q192 and R192
Products: -
Products: -
?
N-(2-oxotetrahydrofuran-3-yl)nonanamide + H2O
3-hydroxy-2-(nonanoylamino)propanoate
Substrates: -
Products: -
Products: -
?
N-(2-oxotetrahydrofuran-3-yl)pentanamide + H2O
3-hydroxy-2-(pentanoylamino)propanoate
Substrates: -
Products: -
Products: -
?
N-(2-oxotetrahydrofuran-3-yl)pentanamide + H2O
3-hydroxy-2-(pentanoylamino)propanoic acid
Substrates: -
Products: -
Products: -
?
N-(3-oxobutanoyl)-DL-homoserine lactone + H2O
N-(3-oxobutanoyl)-DL-homoserine
Substrates: -
Products: -
Products: -
?
N-(3-oxodecanoyl)-DL-homoserine lactone + H2O
N-(3-oxodecanoyl)-DL-homoserine
Substrates: -
Products: -
Products: -
?
N-(3-oxododecanoyl)-DL-homoserine lactone + H2O
N-(3-oxododecanoyl)-DL-homoserine
Substrates: -
Products: -
Products: -
?
N-(3-oxododecanoyl)-L-homoserine lactone + H2O
N-(3-oxododecanoyl)-L-homoserine
Substrates: -
Products: -
Products: -
?
N-(3-oxohexanoyl)homoserine lactone + H2O
N-(3-oxohexanoyl)homoserine
Substrates: -
Products: -
Products: -
?
N-(3-oxooctanoyl)-DL-homoserine lactone + H2O
N-(3-oxooctanoyl)-DL-homoserine
Substrates: -
Products: -
Products: -
?
N-(3-oxooctanoyl)homoserine lactone + H2O
N-(3-oxooctanoyl)homoserine
Substrates: -
Products: -
Products: -
?
N-butanoyl-DL-homoserine lactone + H2O
N-butanoyl-L-homoserine
Substrates: -
Products: -
Products: -
?
N-butanoylhomoserine lactone + H2O
N-butanoylhomoserine
Substrates: -
Products: -
Products: -
?
N-dodecanoyl-DL-homoserine lactone + H2O
N-dodecanoyl-DL-homoserine
Substrates: -
Products: -
Products: -
?
N-dodecanoylhomoserine lactone + H2O
N-dodecanoylhomoserine
Substrates: -
Products: -
Products: -
?
N-hexanoylhomoserine lactone + H2O
N-hexanoylhomoserine
Substrates: -
Products: -
Products: -
?
N-octanoyl-DL-homoserine lactone + H2O
octanoyl-homoserine
Substrates: -
Products: -
Products: -
?
N-octanoylhomoserine lactone + H2O
N-octanoylhomoserine
Substrates: -
Products: -
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N-oxodecanoyl-DL-homoserine lactone + H2O
N-(3-oxodecanoyl)homoserine
-
Substrates: -
Products: -
Products: -
?
N-oxododecanoyl-DL-homoserine lactone + H2O
?
Substrates: -
Products: -
Products: -
?
nonanoic-1,4-lactone + H2O
4-hydroxynonanoate
Substrates: -
Products: -
Products: -
?
nonanoic-1,5-lactone + H2O
5-hydroxynonanoate
Substrates: -
Products: -
Products: -
?
nonanoic-delta-lactone + H2O
5-hydroxynonanoate
Substrates: -
Products: -
Products: -
?
nonanoic-gamma-lactone + H2O
4-hydroxynonanoate
Substrates: -
Products: -
Products: -
?
octanoyl-L-homoserine lactone + H2O
N-octanoyl-L-homoserine
Substrates: -
Products: -
Products: -
?
pantoyl lactone + H2O
2,4-dihydroxy-3,3-dimethylbutanoic acid
Substrates: -
Products: -
Products: -
?
propylene carbonate + H2O
?
Substrates: enzyme variant Q192: 5.02% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 8.8% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
simvastatin + H2O
?
Substrates: activity with enzyme variant Q192 and R192
Products: -
Products: -
?
undecano-gamma-lactone + H2O
4-hydroxyundecanoic acid
Substrates: enzyme variant Q192: 11.8% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 12.7% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
undecanoic-1,4-lactone + H2O
4-hydroxyundecanoate
Substrates: -
Products: -
Products: -
?
undecanoic-1,5-lactone + H2O
5-hydroxyundecanoate
Substrates: -
Products: -
Products: -
?
undecanoic-delta-lactone + H2O
5-hydroxyundecanoate
Substrates: -
Products: -
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?
undecanoic-gamma-lactone + H2O
4-hydroxyundecanoate
Substrates: -
Products: -
Products: -
?
(1R,5S)-oxabicyclooctenone + H2O
?
Substrates: enzyme variant Q192: 0.82% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 0.75% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
(1S,5R)-oxabicyclooctenone + H2O
?
Substrates: enzyme variant Q192: 1.67% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 2.92% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
2-coumaranone + H2O
(2-hydroxyphenyl)acetic acid
Substrates: -
Products: -
Products: -
?
2-coumaranone + H2O
(2-hydroxyphenyl)acetic acid
Substrates: enzyme variant Q192: 18.3% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 13.5% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
2-coumaranone + H2O
(2-hydroxyphenyl)acetic acid
-
Substrates: -
Products: -
Products: -
?
2-coumaranone + H2O
?
-
Substrates: 25% of activity compared to L-pantoyl lactone
Products: -
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2-coumaranone + H2O
?
-
Substrates: 25% of activity compared to L-pantoyl lactone
Products: -
Products: -
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3,4-dihydrocoumarin + H2O
?
-
Substrates: 23% of activity compared to L-pantoyl lactone
Products: -
Products: -
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3,4-dihydrocoumarin + H2O
?
-
Substrates: 23% of activity compared to L-pantoyl lactone
Products: -
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3-oxo-decanoyl-L-homoserine lactone + H2O
N-(3-oxodecanoyl)-L-homoserine
Substrates: -
Products: -
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3-oxo-decanoyl-L-homoserine lactone + H2O
N-(3-oxodecanoyl)-L-homoserine
Substrates: -
Products: -
Products: -
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5-(thiobutyl)butyrolactone + H2O
?
Substrates: the lactonase and the esterase activity of PON1 is mediated by the His115-His134
Products: -
Products: -
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5-(thiobutyl)butyrolactone + H2O
?
Substrates: the lactonase and the esterase activity of PON1 is mediated by the His115-His134 dyad
Products: -
Products: -
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7-oxo-N-(2-oxotetrahydrofuran-3-yl)nonanamide + H2O
3-hydroxy-2-[(7-oxononanoyl)amino]propanoic acid
Substrates: -
Products: -
Products: -
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7-oxo-N-(2-oxotetrahydrofuran-3-yl)nonanamide + H2O
3-hydroxy-2-[(7-oxononanoyl)amino]propanoic acid
Substrates: -
Products: -
Products: -
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beta-hydroxybutyrolactone + H2O
?
Substrates: enzyme variant Q192: 3.83% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 7.53% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
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delta-decanolactone + H2O
5-hydroxydecanoic acid
Substrates: -
Products: -
Products: -
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delta-decanolactone + H2O
5-hydroxydecanoic acid
Substrates: enzyme variant Q192: 9.65% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 12.8% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
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delta-nonalactone + H2O
5-hydroxynonanoate
Substrates: -
Products: -
Products: -
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delta-nonalactone + H2O
5-hydroxynonanoate
Substrates: -
Products: -
Products: -
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delta-nonalactone + H2O
5-hydroxynonanoate
Substrates: -
Products: -
Products: -
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delta-nonalactone + H2O
5-hydroxynonanoic acid
Substrates: -
Products: -
Products: -
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delta-nonalactone + H2O
5-hydroxynonanoic acid
Substrates: -
Products: -
Products: -
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delta-valerolactone + H2O
5-hydroxypentanoic acid
Substrates: -
Products: -
Products: -
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delta-valerolactone + H2O
5-hydroxypentanoic acid
Substrates: -
Products: -
Products: -
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delta-valerolactone + H2O
5-hydroxypentanoic acid
Substrates: -
Products: -
Products: -
?
delta-valerolactone + H2O
5-hydroxypentanoic acid
Substrates: enzyme variant Q192: 75.4% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 71.0% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
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delta-valerolactone + H2O
5-hydroxypentanoic acid
Substrates: -
Products: -
Products: -
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)-propionic acid
-
Substrates: -
Products: -
Products: -
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)-propionic acid
Substrates: weak activity
Products: -
Products: -
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dihydrocoumarin + H2O
3-(2-hydroxyphenyl)-propionic acid
Substrates: -
Products: -
Products: -
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dihydrocoumarin + H2O
3-(2-hydroxyphenyl)-propionic acid
Substrates: -
Products: -
Products: -
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propanoic acid
-
Substrates: -
Products: -
Products: -
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propanoic acid
Substrates: -
Products: -
Products: -
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propanoic acid
Substrates: -
Products: -
Products: -
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propanoic acid
Substrates: -
Products: -
Products: -
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propanoic acid
Substrates: -
Products: -
Products: -
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propanoic acid
Substrates: enzyme variant Q192: 14.3% of the activity with phenyl acetate (cf. EC 3.1.1.2), enzyme variant R192: 17% of the activity with phenyl acetate (cf. EC 3.1.1.2)
Products: -
Products: -
?
dihydrocoumarin + H2O
3-(2-hydroxyphenyl)propanoic acid
Substrates: -
Products: -
Products: -
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dodecanoic-delta-lactone + H2O
5-hydroxydodecanoate