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Literature summary for 3.1.1.25 extracted from

  • Zhang, Y.; Liu, H.; He, J.; Xu, K.; Bai, H.; Wang, Y.; Zhang, F.; Zhang, J.; Cheng, L.; Fan, P.
    Lactonase activity and status of paraoxonase 1 in Chinese women with polycystic ovarian syndrome (2015), Eur. J. Endocrinol., 172, 391-402 .
    View publication on PubMed

Protein Variants

Protein Variants Comment Organism
L55M the mutant enzyme shows decreased lactonase activities compared to the wild type Homo sapiens
Q192R the mutant enzyme shows increased lactonase activities compared to the wild type Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood serum
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-thiobutyl butyrolactone + H2O
-
Homo sapiens 4-(butylsulfanyl)-4-hydroxybutanoic acid
-
?
7-O-diethylphosphoryl-3-cyano-4-methyl-7-hydroxycoumarin + H2O
-
Homo sapiens (2Z)-2-cyano-3-[4-[(diethoxyphosphoryl)oxy]-2-hydroxyphenyl]but-2-enoic acid
-
?

Expression

Organism Comment Expression
Homo sapiens enzyme activities and levels are higher in polycystic ovarian syndrome patients than in the control group up