Activating Compound | Comment | Organism | Structure |
---|---|---|---|
apolipoprotein apoA-I | only apolipoprotein apoA-I is capable of stimulating the lactonase activity, while apoA-IV and apoA-II have almost no effect | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.3 | - |
gamma-dodecanoic lactone | pH 8.3, activity buffer with 0.01 mM apolipoprotein apoA-I rHDL | Homo sapiens | |
0.5 | - |
delta-valerolactone | pH 8.3, activity buffer with 0.01 mM apolipoprotein apoA-I rHDL | Homo sapiens | |
0.7 | - |
gamma-dodecanoic lactone | pH 8.3, activity buffer with 0.1% tergitol | Homo sapiens | |
0.9 | - |
delta-valerolactone | pH 8.3, activity buffer with 0.1% tergitol | Homo sapiens | |
1 | - |
delta-valerolactone | pH 8.3, activity buffer | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P27169 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
delta-valerolactone + H2O | - |
Homo sapiens | 5-hydroxypentanoic acid | - |
? | |
gamma-dodecanoic lactone + H2O | - |
Homo sapiens | 4-hydroxydodecanoic acid | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
34 | - |
gamma-dodecanoic lactone | pH 8.3, activity buffer with 0.1% tergitol | Homo sapiens | |
94 | - |
delta-valerolactone | pH 8.3, activity buffer | Homo sapiens | |
101 | - |
gamma-dodecanoic lactone | pH 8.3, activity buffer with 0.01 mM apolipoprotein apoA-I rHDL | Homo sapiens | |
156 | - |
delta-valerolactone | pH 8.3, activity buffer with 0.1% tergitol | Homo sapiens | |
632 | - |
delta-valerolactone | pH 8.3, activity buffer with 0.01 mM apolipoprotein apoA-I rHDL | Homo sapiens |