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Literature summary for 3.1.1.25 extracted from
- Structure-reactivity studies of serum paraoxonase PON1 suggest that its native activity is lactonase (2005), Biochemistry, 44, 6371-6382.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.129 | - |
dihydrocoumarin | pH 8.0 | Homo sapiens |  |
| 0.22 | - |
gamma-dodecanoic acid lactone | pH 8.0 | Homo sapiens | |
| 0.39 | - |
gamma-nonanoic acid lactone | pH 8.0 | Homo sapiens | |
| 0.57 | - |
delta-valerolactone | pH 8.0 | Homo sapiens | |
| 0.58 | - |
gamma-heptanolide | pH 8.0 | Homo sapiens | |
| 0.6 | - |
gamma-undecanoic acid lactone | pH 8.0 | Homo sapiens | |
| 0.812 | - |
delta-nonalactone | pH 8.0 | Homo sapiens | |
| 1 | - |
Gamma-caprolactone | pH 8.0 | Homo sapiens | |
| 4.3 | - |
pantoyl lactone | pH 8.0 | Homo sapiens | |
| 21 | - |
gamma-butyrolactone | pH 8.0 | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P27169 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-methoxyphenyl acetate + H2O | - |
Homo sapiens | 4-methoxyphenol + acetate | - |
? | |
| delta-nonalactone + H2O | - |
Homo sapiens | 5-hydroxynonanoic acid | - |
? | |
| delta-valerolactone + H2O | - |
Homo sapiens | 5-hydroxypentanoic acid | - |
? | |
| dihydrocoumarin + H2O | - |
Homo sapiens | 3-(2-hydroxyphenyl)propanoic acid | - |
? | |
| ethyl acetate + H2O | - |
Homo sapiens | ethanol + acetate | - |
? | |
| gamma-butyrolactone + H2O | - |
Homo sapiens | 4-hydroxybutanoic acid | - |
? | |
| gamma-caprolactone + H2O | - |
Homo sapiens | 4-hydroxyhexanoic acid | - |
? | |
| gamma-dodecanoic acid lactone + H2O | - |
Homo sapiens | 4-hydroxydodecanoic acid | - |
? | |
| gamma-heptanolide + H2O | - |
Homo sapiens | 4-hydroxyheptanoic acid | - |
? | |
| gamma-nonanoic acid lactone + H2O | - |
Homo sapiens | 4-hydroxynonanoic acid | - |
? | |
| gamma-undecanoic acid lactone + H2O | - |
Homo sapiens | 4-hydroxyundecanoic acid | - |
? | |
| pantoyl lactone + H2O | - |
Homo sapiens | 2,4-dihydroxy-3,3-dimethylbutanoic acid | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 11.9 | - |
pantoyl lactone | pH 8.0 | Homo sapiens | |
| 26.4 | - |
gamma-dodecanoic acid lactone | pH 8.0 | Homo sapiens | |
| 31 | - |
gamma-nonanoic acid lactone | pH 8.0 | Homo sapiens | |
| 34 | - |
gamma-heptanolide | pH 8.0 | Homo sapiens | |
| 39 | - |
4-methoxy phenyl acetate | pH 8.0 | Homo sapiens | |
| 44 | - |
Gamma-caprolactone | pH 8.0 | Homo sapiens | |
| 48 | - |
delta-nonalactone | pH 8.0 | Homo sapiens | |
| 62 | - |
gamma-undecanoic acid lactone | pH 8.0 | Homo sapiens | |
| 111 | - |
gamma-butyrolactone | pH 8.0 | Homo sapiens | |
| 152 | - |
dihydrocoumarin | pH 8.0 | Homo sapiens | |
| 210 | - |
delta-valerolactone | pH 8.0 | Homo sapiens | |
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