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Literature summary for 3.1.1.25 extracted from
- Purification and properties of an enzyme in human blood and rat liver microsomes catalyzing the formation and hydrolysis of gamma-lactones. II. Metal ion effects, kinetics, and equilibria (1966), J. Biol. Chem., 241, 4842-4847.
General Stability
| General Stability | Organism |
|---|---|
| Ca2+, 1 mM, stabilizes | Homo sapiens |
| Ca2+, 1 mM, stabilizes | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | only inhibition of hydrolytic activity without affecting its lactonizing function | Homo sapiens |  |
| Mg2+ | only inhibition of hydrolytic activity without affecting its lactonizing function | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.9 | - |
Gamma-caprolactone | - |
Homo sapiens | |
| 1.3 | - |
Gamma-octalactone | - |
Homo sapiens | |
| 2.2 | - |
Gamma-caprolactone | - |
Rattus norvegicus | |
| 3.1 | - |
Gamma-octalactone | - |
Rattus norvegicus | |
| 3.3 | - |
gamma-valerolactone | - |
Homo sapiens | |
| 4 | - |
gamma-valerolactone | - |
Rattus norvegicus | |
| 4.5 | - |
3-hydroxyoctanoate | - |
Homo sapiens | |
| 5.7 | - |
Gamma-hydroxycaproate | - |
Rattus norvegicus | |
| 6 | - |
gamma-butyrolactone | - |
Rattus norvegicus | |
| 9 | - |
Gamma-hydroxyvalerate | - |
Homo sapiens | |
| 10.4 | - |
Gamma-hydroxyvalerate | - |
Homo sapiens | |
| 13.3 | - |
gamma-butyrolactone | - |
Homo sapiens | |
| 20 | - |
Gamma-hydroxyvalerate | - |
Rattus norvegicus | |
| 140 | - |
gamma-hydroxybutyrate | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | activates, hydrolysis is maximal at 0.01 mM , lactonization is maximal with 10 mM | Homo sapiens | |
| Ca2+ | activates, hydrolysis is maximal at 0.01 mM , lactonization is maximal with 10 mM | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood plasma | - |
Homo sapiens | - |
| blood plasma | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3-hydroxyoctanoate + H2O | - |
Homo sapiens | ? | - |
? | |
| gamma-butyrolactone + H2O | - |
Homo sapiens | gamma-hydroxybutyrate | - |
r | |
| gamma-butyrolactone + H2O | - |
Rattus norvegicus | gamma-hydroxybutyrate | - |
r | |
| gamma-caprolactone + H2O | - |
Homo sapiens | gamma-hydroxycaproate | - |
? | |
| gamma-caprolactone + H2O | - |
Rattus norvegicus | gamma-hydroxycaproate | - |
? | |
| gamma-octalactone + H2O | - |
Homo sapiens | 4-hydroxyoctanoate | - |
? | |
| gamma-octalactone + H2O | - |
Rattus norvegicus | 4-hydroxyoctanoate | - |
? | |
| gamma-valerolactone + H2O | - |
Homo sapiens | gamma-hydroxyvalerate | - |
? | |
| gamma-valerolactone + H2O | - |
Rattus norvegicus | gamma-hydroxyvalerate | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
- |
Homo sapiens |
| 6 | - |
- |
Rattus norvegicus |
| 8.6 | - |
- |
Homo sapiens |
| 8.6 | - |
- |
Rattus norvegicus |
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