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Literature summary for 3.1.1.25 extracted from
- The effect of divalent metal chelators and cadmium on serum phosphotriesterase, lactonase and arylesterase activities of paraoxonase 1 (2018), Environ. Toxicol. Pharmacol., 58, 77-83 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| CdCl2 | 77.7% residual activity after 24 h in the presence of 0.02 mg/ml CdCl2 | Homo sapiens |  |
| D-penicillamine | 32.4% residual activity after 24 h in the presence of 0.2 mg/ml D-penicillamine | Homo sapiens | |
| EDTA | 50.3% residual activity after 24 h in the presence of 0.05 mg/ml EDTA | Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | the enzyme has two Ca2+ binding sites | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood serum | - |
Homo sapiens | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| 4°C, the enzyme activity is significantly lower after 48 h as well as after 1, 2 and 4 weeks storage when compared to enzyme activities assayed in fresh serum | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydrocoumarin + H2O | - |
Homo sapiens | 3-(2-hydroxyphenyl)propanoic acid | - |
? | |
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