Any feedback?
Please rate this page
(enzyme.php)
(0/150)

BRENDA support

Filter enzyme data
show all tables | show all data
hide all tables
No. of entries

Information on EC 2.3.1.9 - acetyl-CoA C-acetyltransferase

for references in articles please use BRENDA:EC2.3.1.9

Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
IUBMB Comments

The enzyme, found in both eukaryotes and prokaryotes, catalyses the Claisen condensation of an acetyl-CoA and an acyl-CoA (often another acetyl-CoA), leading to the formation of an acyl-CoA that is longer by two carbon atoms. The reaction starts with the acylation of a nucleophilic cysteine at the active site, usually by acetyl-CoA but potentially by a different acyl-CoA, with concomitant release of CoA. In the second step the acyl group is transferred to an acetyl-CoA molecule. cf. EC 2.3.1.16, acetyl-CoA C-acyltransferase.

The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea
Reaction Schemes
hide(Overall reactions are displayed. Show all >>)
2
acetyl-CoA
=
CoA
+
acetoacetyl-CoA
2
=
+

Synonyms
acetoacetyl-coa thiolase, acetyl-coa acetyltransferase, erg10, acoat, acetyl-coa c-acetyltransferase, cytosolic acetoacetyl-coa thiolase, 2-methylacetoacetyl-coa thiolase, osat1, acetoacetyl coa thiolase, aact2, more

REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
2 acetyl-CoA = CoA + acetoacetyl-CoA
show the reaction diagram
acetyl-CoA + [acetyl-CoA C-acetyltransferase]-L-cysteine = [acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine + CoA
show the reaction diagram
(1a)
-
-
-
[acetyl-CoA C-acetyltransferase]-S-acetyl-L-cysteine + acetyl-CoA = acetoacetyl-CoA + [acetyl-CoA C-acetyltransferase]-L-cysteine
show the reaction diagram
(1b)
-
-
-
PATHWAY SOURCE
PATHWAYS
MetaCyc
(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered), 2-deoxy-D-ribose degradation II, 2-methylpropene degradation, 3-hydroxypropanoate/4-hydroxybutanate cycle, 4-oxopentanoate degradation, acetoacetate degradation (to acetyl CoA), acetyl-CoA fermentation to butanoate, crotonate fermentation (to acetate and cyclohexane carboxylate), ethylmalonyl-CoA pathway, glutaryl-CoA degradation, isoprene biosynthesis II (engineered), isopropanol biosynthesis (engineered), ketogenesis, ketolysis, L-glutamate degradation V (via hydroxyglutarate), L-lysine fermentation to acetate and butanoate, methyl tert-butyl ether degradation, mevalonate pathway I (eukaryotes and bacteria), mevalonate pathway II (haloarchaea), mevalonate pathway III (Thermoplasma), mevalonate pathway IV (archaea), oleate beta-oxidation, polyhydroxybutanoate biosynthesis, pyruvate fermentation to acetone, pyruvate fermentation to butanoate, pyruvate fermentation to butanol I, pyruvate fermentation to butanol II (engineered), pyruvate fermentation to hexanol (engineered), valproate beta-oxidation
Highest Expressing Human Cell Lines
Cell Line Links Gene Links