Literature summary for 2.3.1.9 extracted from

Greenspan, M.D.; Yudkovitz, J.B.; Chen, J.S.; Hanf, D.P.; Chang, M.N.; Chiang, P.Y.C.; Chabala, J.C.; Alberts, A.W.
The inhibition of cytoplasmic acetoacetyl-CoA thiolase by a triyne carbonate (L-660, 631) (1989), Biochem. Biophys. Res. Commun., 163, 548-553.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-Oxo-5-(1-hydroxy-2,4,6-heptatriynyl)-1,3-dioxolone-4-heptanoic acid	natural product isolated from actinomycete culture L-660,631, IC50: 0.00001 mM,	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Rattus norvegicus	5829	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CoA + acetoacetyl-CoA	Rattus norvegicus	-	acetyl-CoA + acetyl-CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CoA + acetoacetyl-CoA	-	Rattus norvegicus	acetyl-CoA + acetyl-CoA	-	?
CoA + acetoacetyl-CoA	-	Rattus norvegicus	acetyl-CoA + acetyl-CoA	-	r

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00001	-	natural product isolated from actinomycete culture L-660,631, IC50: 0.00001 mM,	Rattus norvegicus	2-Oxo-5-(1-hydroxy-2,4,6-heptatriynyl)-1,3-dioxolone-4-heptanoic acid

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Release 2023.1 (January 2023)