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BRENDA support

Ligand acetyl-CoA

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Basic Ligand Information

Molecular Structure
Picture of acetyl-CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
Molfile
C23H38N7O17P3S
acetyl-CoA
ZSLZBFCDCINBPY-ZSJPKINUSA-N
Synonyms:
ac-CoA, AcCoA, Acetyl-CoA derivates, acetyl-SCoA, acetyl Co-A, acetylCoA, acetyl CoA, acetylcoenzyme A, acetyl coenzyme A, S-acetyl-CoA

Related pathways

Pathway Source
Pathways
KEGG
Aflatoxin biosynthesis, Alcoholic liver disease, AMPK signaling pathway, Benzoate degradation, beta-Alanine metabolism more
MetaCyc
(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase), (8E,10E)-dodeca-8,10-dienol biosynthesis, (aminomethyl)phosphonate degradation, (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered), (R)-camphor degradation more


Show all pahtways known for Show all BRENDA pathways known for acetyl-CoA

Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (2006 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA = acetoacetyl-CoA + CoA
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + dephospho-CoA = CoA + acetyl-dephospho-CoA
show the reaction diagram
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[biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA = [biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA
show the reaction diagram
acetyl-CoA + hydrogen sulfide = CoA + thioacetate
show the reaction diagram
-
acetyl-CoA + L-N6-hydroxylysine = CoA + N6-acetyl-N6-hydroxylysine
show the reaction diagram
-
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate = CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
show the reaction diagram
-
acetyl-CoA + thioethanolamine = CoA + S-acetylthioethanolamine
show the reaction diagram
-
acetyl-CoA + dolichol = CoA + dolichyl acetate
show the reaction diagram
-
acetyl-CoA + L-carnitine = CoA + acetyl-carnitine
show the reaction diagram
-
myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA
show the reaction diagram
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acetyl-CoA + 16-epivellosimine = CoA + vinorine
show the reaction diagram
-
acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate
show the reaction diagram
-
acetyl-CoA + 10-desacetyltaxuyunnanin C = CoA + taxuyunnanin C
show the reaction diagram
-
acetyl-CoA + 10-deacetylbaccatin III = CoA + baccatin III
show the reaction diagram
-
acetyl-CoA + deacetylcephalosporin C = CoA + cephalosporin C
show the reaction diagram
-
[elongator tRNAMet]-cytidine34 + ATP + acetyl-CoA = [elongator tRNAMet]-N4-acetylcytidine34 + ADP + phosphate + coenzyme A
show the reaction diagram
-
acetyl-CoA + imidazole = CoA + N-acetylimidazole
show the reaction diagram
-
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
show the reaction diagram
-
acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A
show the reaction diagram
-
acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose
show the reaction diagram
-
acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose
show the reaction diagram
-
2-acyl-sn-glycerol + acetyl-CoA = diacylglycerol + CoA
show the reaction diagram
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acetyl-CoA + GDP-4-amino-4,6-dideoxy-alpha-D-mannose = CoA + GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose
show the reaction diagram
-
acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+ = 5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+
show the reaction diagram
-
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ = 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
show the reaction diagram
-
acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O
show the reaction diagram
-
(5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate
show the reaction diagram
-
acetyl-CoA + an N-terminal-L-methionyl-[transmembrane protein] = an N-terminal-Nalpha-acetyl-L-methionyl-[transmembrane protein] + CoA
show the reaction diagram
-
acetyl-CoA + (3S)-3,6-diaminohexanoate = CoA + (3S)-6-acetamido-3-aminohexanoate
show the reaction diagram
-
ethanol + acetyl-CoA = ethyl acetate + CoA
show the reaction diagram
-
acetyl-CoA + cortisol = CoA + cortisol 21-acetate
show the reaction diagram
-
acetyl-CoA + alpha-D-galactosamine 1-phosphate = CoA + N-acetyl-alpha-D-galactosamine 1-phosphate
show the reaction diagram
-
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine
show the reaction diagram
-
acetyl-CoA + D-glucosamine = CoA + N-acetyl-D-glucosamine
show the reaction diagram
acetyl-CoA + malonyl-[acyl-carrier protein] = 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
show the reaction diagram
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acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-decaprenol = CoA + 2-O-acetyl-alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-decaprenol
show the reaction diagram
-
acetyl-CoA + L-lysine = CoA + N6-acetyl-L-lysine
show the reaction diagram
-
acetyl-CoA + 6-diazo-5-oxo-L-norleucine = CoA + N-acetyl-6-diazo-5-oxo-L-norleucine
show the reaction diagram
-
acetyl-CoA + a [beta-tubulin]-L-lysine = CoA + a [beta-tubulin]-N6-acetyl-L-lysine
show the reaction diagram
-
acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine
show the reaction diagram
-
acetyl-CoA + uridine34 in tRNA + S-adenosyl-L-methionine + H2O = CoA + 5-(carboxymethyl)uridine34 in tRNA + L-methionine + 5'-deoxyadenosine
show the reaction diagram
-
acetyl-CoA + D-glutamate = N-acetyl-D-glutamate + CoA
show the reaction diagram
-
acetyl-CoA + N-hydroxyputrescine = N1-acetyl-N1-hydroxyputrescine + CoA
show the reaction diagram
-
3-dehydrocarnitine + acetyl-CoA = acetoacetate + betainyl-CoA
show the reaction diagram
-
3-oxoadipate + acetyl-CoA = acetoacetate + succinyl-CoA
show the reaction diagram
-
3,5-dioxohexanoate + acetyl-CoA = acetoacetate + acetoacetyl-CoA
show the reaction diagram
-
acetyl-CoA + rhazimol = CoA + akuammiline
show the reaction diagram
-
acetyl-CoA + stemmadenine = CoA + stemmadenine acetate
show the reaction diagram
-
acetyl-CoA + (19E)-17,18-epoxy-17-hydroxycur-19-ene = CoA + diaboline
show the reaction diagram
-
acetyl-CoA + L-histidine = CoA + N-acetyl-L-histidine
show the reaction diagram
-
acetyl-CoA + L-2-phenylglycine = (2S)-2-acetylamino-2-phenylacetic acid + CoA
show the reaction diagram
-
acetyl-CoA + D-tryptophan = CoA + acetyl-D-tryptophan
show the reaction diagram
-
acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]
show the reaction diagram
acetyl-CoA + an [acyl-carrier protein] = CoA + an acetyl-[acyl-carrier protein]
show the reaction diagram
-
acetyl-CoA + N-acetylneuraminate = CoA + N-acetyl-4-O-acetylneuraminate
show the reaction diagram
-
acetyl-CoA + L-phenylalanine = CoA + N-acetyl-L-phenylalanine
show the reaction diagram
-
acetyl-CoA + L-leucine = CoA + N-acetyl-L-leucine
show the reaction diagram
-
cis-11-eicosenol + acetyl-CoA = cis-11-eicosenyl acetate + CoA
show the reaction diagram
-
acetyl-CoA + an S-substituted L-cysteine = CoA + an S-substituted N-acetyl-L-cysteine
show the reaction diagram
-
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
show the reaction diagram
-
acetyl-CoA + malonyl-CoA + NADH + NADPH = ?
show the reaction diagram
-
acetyl-CoA + [DNA-binding protein Alba1]-L-lysine16 = CoA + [DNA-binding protein Alba1]-N6-acetyl-L-lysine16
show the reaction diagram
-
acetyl-CoA + actin = CoA + N-acetyl-actin
show the reaction diagram
-
myriocin + acetyl-CoA = N-acetyl-myriocin + CoA
show the reaction diagram
-
acetyl-CoA + H2O + oxaloacetate = citrate + CoA
show the reaction diagram
-
acetyl-CoA + citrate = acetate + (3S)-citryl-CoA
show the reaction diagram
-
acetyl-CoA + malonate = acetate + malonyl-CoA
show the reaction diagram
-
ethanol + acetyl-CoA = ethyl acetate + CoA
show the reaction diagram
-
glycine betaine-CoA + acetyl-CoA = glycine betaine + HS-CoA
show the reaction diagram
-
acetyl-CoA + glyoxylate = (2S)-4-malyl-CoA
show the reaction diagram
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CheY + acetyl-CoA + ATP = acetyl-CheY + CoA + AMP + diphosphate
show the reaction diagram
-

In Vivo Product in Enzyme-catalyzed Reactions (114 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
show the reaction diagram
-
-
3-oxopropanoate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
show the reaction diagram
-
malonate semialdehyde + CoA + NAD+ = acetyl-CoA + CO2 + NADH
show the reaction diagram
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-
pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH
show the reaction diagram
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-
pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
show the reaction diagram
-
-
pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+
show the reaction diagram
-
-
[biotin carboxyl-carrier protein]-N6-biotinyl-L-lysine + malonyl-CoA = [biotin carboxyl-carrier protein]-N6-carboxybiotinyl-L-lysine + acetyl-CoA
show the reaction diagram
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CO + CoA + a [methyl-Co(III) corrinoid Fe-S protein] = acetyl-CoA + a [Co(I) corrinoid Fe-S protein]
show the reaction diagram
-
-
3-hydroxy-5-phosphonooxypentane-2,4-dione + coenzyme A = glycerone phosphate + acetyl-CoA
show the reaction diagram
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-
CoA + acetyl phosphate = acetyl-CoA + phosphate
show the reaction diagram
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-
acetate + propanoyl-CoA = acetyl-CoA + propanoate
show the reaction diagram
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-
5-hydroxypentanoyl-CoA + acetate = acetyl-CoA + 5-hydroxypentanoate
show the reaction diagram
-
succinyl-CoA + acetate = acetyl-CoA + succinate
show the reaction diagram
-
-
acetate + oxalyl-CoA = acetyl-CoA + oxalate
show the reaction diagram
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-
(3S)-citryl-CoA = acetyl-CoA + oxaloacetate
show the reaction diagram
653277, -
-
(1-hydroxycyclohexan-1-yl)acetyl-CoA = acetyl-CoA + cyclohexanone
show the reaction diagram
-
(S)-3-Hydroxy-3-methylglutaryl-CoA = Acetyl-CoA + acetoacetate
show the reaction diagram
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-
ATP + acetate + CoA = ADP + phosphate + acetyl-CoA
show the reaction diagram
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-
ATP + acetate + CoA = ADP + phosphate + acetyl-CoA
show the reaction diagram
-
-

Substrate in Enzyme-catalyzed Reactions (6655 results)

EC NUMBER
REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
acetyl-CoA + NADPH = acetaldehyde + CoA + NADP+
show the reaction diagram
-
acetyl-CoA = acetoacetyl-CoA + CoA
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + NADH + H+ = acetaldehyde + CoA + NAD+
show the reaction diagram
-
acetyl-CoA + NADPH + H+ = ?
show the reaction diagram
-
acetyl-CoA + oxaloacetate = malonyl-CoA + pyruvate
show the reaction diagram
-
acetyl-CoA + hydrogen sulfide = CoA + thioacetate
show the reaction diagram
-
acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate = CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
show the reaction diagram
-
acetyl-CoA + thioethanolamine = CoA + S-acetylthioethanolamine
show the reaction diagram
-
acetyl-CoA + dolichol = CoA + dolichyl acetate
show the reaction diagram
-
acetyl-CoA + glycine = CoA + N-acetylglycine
show the reaction diagram
-
glutathione-S-transferase + acetyl-CoA = ?
show the reaction diagram
-
3 malonyl-CoA + acetyl-CoA = 4 CoA + 4-hydroxy-6-methyl-2H-pyran-2-one + 3 CO2
show the reaction diagram
-
acetyl-CoA + malonyl-CoA = ? + CoA + CO2
show the reaction diagram
-
acetyl-CoA + 10-desacetyltaxuyunnanin C = CoA + taxuyunnanin C
show the reaction diagram
-
acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide
show the reaction diagram
-
acetyl-CoA + shisonin = CoA + acetylshisonin
show the reaction diagram
-
acetyl-CoA + deacetylcephalosporin C = CoA + cephalosporin C
show the reaction diagram
-
acetyl-CoA + dTDP-3-amino-3,6-dideoxy-alpha-D-galactopyranose = CoA + dTDP-3-acetamido-3,6-dideoxy-alpha-D-galactopyranose
show the reaction diagram
-
acetyl-CoA + imidazole = CoA + N-acetylimidazole
show the reaction diagram
-
acetyl-CoA + 1,2-diacetyl-sn-glycerol = CoA + triacetylglycerol
show the reaction diagram
-
acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
show the reaction diagram
-
acetyl-CoA + UDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine = CoA + UDP-2,4-diacetamido-2,4,6-trideoxy-beta-L-altropyranose
show the reaction diagram
acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A
show the reaction diagram
-
acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose
show the reaction diagram
-
acetyl-CoA + L-carnitine = CoA + L-acetylcarnitine
show the reaction diagram
-
acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose
show the reaction diagram
-
acetyl-CoA + phosphate = CoA + acetyl phosphate
show the reaction diagram
-
acetyl-CoA + GDP-4-amino-4,6-dideoxy-alpha-D-mannose = CoA + GDP-4-acetamido-4,6-dideoxy-alpha-D-mannose
show the reaction diagram
-
lyso-platelet-activating factor + acetyl-CoA = platelet-activating factor + CoA
show the reaction diagram
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acetyl-CoA + 5 malonyl-CoA + 3 NADPH + 3 H+ = 5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 4 H2O + 3 NADP+
show the reaction diagram
-
acetyl-CoA + 5 malonyl-CoA + 2 NADPH + 2 H+ = 2-hydroxy-5-methyl-1-naphthoate + 6 CoA + 5 CO2 + 3 H2O + 2 NADP+
show the reaction diagram
-
acetyl-CoA + malonyl-CoA + [2-methylbutanoate polyketide synthase] + 2 NADPH + 2 H+ + S-adenosyl-L-methionine = (S)-2-methylbutanoyl-[2-methylbutanoate polyketide synthase] + 2 CoA + CO2 + 2 NADP+ + S-adenosyl-L-homocysteine + H2O
show the reaction diagram
-
(5S)-5-amino-3-oxohexanoate + acetyl-CoA = L-3-aminobutanoyl-CoA + acetoacetate
show the reaction diagram
-
acetyl-CoA + cholesterol = CoA + cholesteryl acetate
show the reaction diagram
-
acetyl-CoA + (3S)-3,6-diaminohexanoate = CoA + (3S)-6-acetamido-3-aminohexanoate
show the reaction diagram
-
acetyl-CoA + cortisol = CoA + cortisol 21-acetate
show the reaction diagram
-
acetyl-CoA + alpha-D-galactosamine 1-phosphate = CoA + N-acetyl-alpha-D-galactosamine 1-phosphate
show the reaction diagram
-
acetyl-CoA + (13S,14R)-1,13-dihydroxy-N-methylcanadine = (13S,14R)-13-O-acetyl-1-hydroxy-N-methylcanadine + CoA
show the reaction diagram
-
acetyl-CoA + [protein]-L-lysine = CoA + [protein]-N6-acetyl-L-lysine
show the reaction diagram
-
acetyl-CoA + malonyl-[acyl-carrier protein] = 3-oxobutanoyl-[acyl-carrier protein] + CoA + CO2
show the reaction diagram
-
acetyl-CoA + alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-decaprenol = CoA + 2-O-acetyl-alpha-L-Rha-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Gal-PP-decaprenol
show the reaction diagram
-
acetyl-CoA + 6-diazo-5-oxo-L-norleucine = CoA + N-acetyl-6-diazo-5-oxo-L-norleucine
show the reaction diagram
-
acetyl-CoA + a [beta-tubulin]-L-lysine = CoA + a [beta-tubulin]-N6-acetyl-L-lysine
show the reaction diagram
-
acetyl-CoA + uridine34 in tRNA + S-adenosyl-L-methionine + H2O = CoA + 5-(carboxymethyl)uridine34 in tRNA + L-methionine + 5'-deoxyadenosine
show the reaction diagram
-
acetyl-CoA + cyclohexane-1-carboxylate = acetate + cyclohexane-1-carbonyl-CoA
show the reaction diagram
-
acetyl-CoA + N-hydroxyputrescine = N1-acetyl-N1-hydroxyputrescine + CoA
show the reaction diagram
-
3-dehydrocarnitine + acetyl-CoA = acetoacetate + betainyl-CoA
show the reaction diagram
-
3-oxoadipate + acetyl-CoA = acetoacetate + succinyl-CoA
show the reaction diagram
-
3,5-dioxohexanoate + acetyl-CoA = acetoacetate + acetoacetyl-CoA
show the reaction diagram
-
acetyl-CoA + rhazimol = CoA + akuammiline
show the reaction diagram
-
acetyl-CoA + stemmadenine = CoA + stemmadenine acetate
show the reaction diagram
-
acetyl-CoA + (19E)-17,18-epoxy-17-hydroxycur-19-ene = CoA + diaboline
show the reaction diagram
-
acetyl-CoA + D-tryptophan = CoA + acetyl-D-tryptophan
show the reaction diagram
-
acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate
show the reaction diagram
-
acetyl-CoA + glycine = ?
show the reaction diagram
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