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Literature summary for 2.3.1.9 extracted from

  • Kursula, P.; Sikkilae, H.; Fukao, T.; Kondo, N.; Wierenga, R.K.
    High resolution crystal structures of human cytosolic thiolase (CT): A comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I (2005), J. Mol. Biol., 347, 189-201.
    View publication on PubMed
Search for more literature for 2.3.1.9

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
only successful in the presence of CoA Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + acetyl-CoA Escherichia coli
-
 CoA + acetoacetyl-CoA
-
 r
acetyl-CoA + acetyl-CoA Zoogloea ramigera
-
 CoA + acetoacetyl-CoA
-
 r
acetyl-CoA + acetyl-CoA Homo sapiens involved in fatty acid synthesis CoA + acetoacetyl-CoA
-
 r

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Homo sapiens Q9BWD1
-
-
Zoogloea ramigera P07097
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
2 acetyl-CoA = CoA + acetoacetyl-CoA Claisen condensation, mechanism Escherichia coli
a
2 acetyl-CoA = CoA + acetoacetyl-CoA Claisen condensation, mechanism Zoogloea ramigera
a
2 acetyl-CoA = CoA + acetoacetyl-CoA Claisen condensation, mechanism Homo sapiens
a

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + acetyl-CoA
-
 Escherichia coli CoA + acetoacetyl-CoA
-
 r
acetyl-CoA + acetyl-CoA
-
 Zoogloea ramigera CoA + acetoacetyl-CoA
-
 r
acetyl-CoA + acetyl-CoA
-
 Homo sapiens CoA + acetoacetyl-CoA
-
 r
acetyl-CoA + acetyl-CoA involved in fatty acid synthesis Homo sapiens CoA + acetoacetyl-CoA
-
 r

Subunits

Subunits Comment Organism
tetramer four identical subunits Homo sapiens

Synonyms

Synonyms Comment Organism
CT
-
 Escherichia coli
cytosolic acetoacetyl-CoA thiolase
-
 Escherichia coli