Ligand CoA

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Basic Ligand Information

Molecular Structure
Picture of CoA (click for magnification)
Molecular Formula
BRENDA Name
InChIKey
C21H36N7O16P3S
CoA
RGJOEKWQDUBAIZ-IBOSZNHHSA-N
Synonyms:
CoA-SH, CoA-[4'-phosphopantetheine], CoASH, coenzyme-A, coenzyme A, HS-CoA, reduced CoA
Pathway Source
Pathways
MetaCyc
(+)-camphor degradation, (-)-camphor degradation, (1'S,5'S)-averufin biosynthesis, (4R)-carveol and (4R)-dihydrocarveol degradation, (4S)-carveol and (4S)-dihydrocarveol degradation more


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Roles as Enzyme Ligand

In Vivo Substrate in Enzyme-catalyzed Reactions (442 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
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2-oxoglutarate + CoA + NAD+ = succinyl-CoA + CO2 + NADH
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3-oxopropanoate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
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pyruvate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH
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2-oxoglutarate + CoA + NADP+ = succinyl-CoA + CO2 + NADPH
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phenylglyoxylate + NAD+ + CoA-SH = benzoyl-S-CoA + CO2 + NADH
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coniferaldehyde + CoA + NADP+ = feruloyl-CoA + NADPH + H+
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propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+
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pyruvate + CoA + NAD+ = acetyl-CoA + CO2 + NADH
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3-hydroxy-5-phosphonooxypentane-2,4-dione + coenzyme A = glycerone phosphate + acetyl-CoA
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coenzyme A + H2O = ?
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o-succinylbenzoate + CoA = 1,4-dihydroxy-2-naphthoyl-CoA + H2O
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ATP + biotin + CoA = ?
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ATP + acetate + CoA = ADP + phosphate + acetyl-CoA
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ATP + acetoacetate + CoA = AMP + diphosphate + acetoacetyl-CoA
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ATP + citrate + CoA = ADP + phosphate + (3S)-citryl-CoA
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ATP + phytanate + CoA = ?
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ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA
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ATP + 3alpha,7alpha-dihydroxy-5beta-cholestanate + CoA = ?
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ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown
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3-hydroxypropanoate + ATP + coenzyme A = 3-hydroxypropanoyl-CoA + AMP + diphosphate
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ATP + 3-hydroxybenzoate + CoA = AMP + diphosphate + 3-hydroxybenzoyl-CoA
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[(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetate + ATP + CoA = AMP + diphosphate + [(1R)-2,2,3-trimethyl-5-oxocyclopent-3-enyl]acetyl-CoA
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ATP + 4-hydroxybutanoate + CoA = AMP + diphosphate + 4-hydroxybutanoyl-CoA
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ATP + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoate + CoA = AMP + diphosphate + 3-[(3aS,4S,7aS)-7a-methyl-1,5-dioxo-octahydro-1H-inden-4-yl]propanoyl-CoA
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ATP + 2-hydroxy-7-methoxy-5-methyl-1-naphthoate + CoA = AMP + diphosphate + 2-hydroxy-7-methoxy-5-methyl-1-naphthoyl-CoA
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ATP + L-carnitine + CoA = AMP + diphosphate + L-carnitinyl-CoA
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ATP + L-firefly luciferin + CoA = AMP + diphosphate + L-firefly luciferyl-CoA
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ATP + 2-succinylbenzoate + CoA = ADP + phosphate + 2-succinylbenzoyl-CoA
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ATP + 2-(imidazol-4-yl)acetate + CoA = ADP + phosphate + 2-(imidazol-4-yl)acetyl-CoA
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3-phenylpropanoate + CoA + ATP = 3-phenylpropionyl-CoA + AMP + diphosphate
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In Vivo Product in Enzyme-catalyzed Reactions (2393 results)

EC NUMBER
PROVEN IN VIVO REACTION
REACTION DIAGRAM
LITERATURE
ENZYME 3D STRUCTURE
(3,5-dihydroxyphenyl)acetyl-CoA + O2 = (3,5-dihydroxyphenyl)glyoxylate + CoA
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malonyl-CoA + NADPH = malonate-semialdehyde + CoA + NADP+
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tetradecanoyl-CoA + NADPH = tetradecanal + CoA + NADP+
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sulfoacetyl-CoA + NADPH + H+ = 2-sulfoacetaldehyde + CoA + NADP+
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stearoyl-CoA + NADPH = octadecanal + CoA + NADP+
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CoA-glutathione + GSH = CoA + GSSG
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acetyl-CoA + hydrogen sulfide = CoA + thioacetate
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palmitoyl-CoA + myelin proteolipid protein = CoA + myelin proteolipid O-palmitoylprotein
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acetyl-CoA + L-N6-hydroxylysine = CoA + N6-acetyl-N6-hydroxylysine
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acetyl-CoA + 1-alkyl-sn-glycero-3-phosphate = CoA + 1-alkyl-2-acetyl-sn-glycero-3-phosphate
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acetyl-CoA + thioethanolamine = CoA + S-acetylthioethanolamine
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feruloyl-CoA + tyramine = CoA + feruloyltyramine
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eicosanoyl-CoA + 4 methylmalonyl-CoA + 8 NADPH + 8 H+ = tetramethyl-branched mycocerosoyl-CoA + 4 CoA + 4 CO2 + 8 NADP+ + 4 H2O
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malonyl-CoA + D-tryptophan = CoA + N2-malonyl-D-tryptophan
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malonyl-CoA + 3,4-dichloroaniline = CoA + N-(3,4-dichlorophenyl)-malonamate
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apigenin 7-O-apiosylglucoside + malonyl-CoA = apigenin 7-O-apiosylglucoside -6''-O-malonylester + CoA
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malonyl-CoA + kaempferol 3-O-glucoside = CoA + kaempferol 3-O-glucoside malonylester
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caffeoyl-CoA + isocitrate = CoA + 2-caffeoylisocitrate
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benzoyl-CoA + L-ornithine = CoA + N2,N5-dibenzoyl-L-ornithine
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acyl-CoA + glycine = CoA + N-acylglycine
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sinapoyl-CoA + glucarolactone = CoA + O-sinapoylglucarolactone
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caffeoyl-CoA + putrescine = CoA + N-caffeoylputrescine
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phenylacetyl-CoA + L-glutamine = CoA + alpha-N-phenylacetyl-L-glutamine
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(E,E)-piperoyl-CoA + piperidine = CoA + N-[(E,E)-piperoyl]-piperidine
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cinnamoyl-CoA + malonyl-CoA = 3,5-dihydroxystilbene + CoA + CO2
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acetyl-CoA + salutaridinol = CoA + 7-O-acetylsalutaridinol
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benzoyl-CoA + 3 malonyl-CoA = 2,4,6-trihydroxybenzophenone + 4 CoA + 3 CO2
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myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA
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acyl-CoA + 1,2-diacyl-sn-glycerol = CoA + 1,2,3-triacylglycerol
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malonyl-CoA + N-methylanthraniloyl-CoA = CoA + 1,3-dihydroxy-N-methylacridone + CO2
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acetyl-CoA + 16-epivellosimine = CoA + vinorine
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acetyl-CoA + 10-desacetyltaxuyunnanin C = CoA + taxuyunnanin C
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benzoyl-CoA + 10-deacetyl-2-debenzoylbaccatin III = CoA + 10-deacetylbaccatin III
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2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine
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acetyl-CoA + corrinoid protein = CoA + CO + methylcorrinoid protein
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malonyl-CoA + 4-coumaroyl-CoA + NADPH + H+ = CoA + isoliquiritigenin + CO2 + NADP+ + H2O
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malonyl-CoA + delphinidin 3-O-beta-D-glucoside = CoA + delphinidin 3-O-(6-malonyl-beta-D-glucoside)
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4-coumaroyl-CoA + a flavonol 3-O-[beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside] = CoA + a flavonol 3-O-[6-(4-coumaroyl)-beta-D-glucosyl-(1->2)-beta-D-glucosyl-(1->2)-beta-D-glucoside]
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acetyl-CoA + deacetylcephalosporin C = CoA + cephalosporin C
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butanoyl-CoA + phosphate = butanoylphosphate + CoA
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[elongator tRNAMet]-cytidine34 + ATP + acetyl-CoA = [elongator tRNAMet]-N4-acetylcytidine34 + ADP + phosphate + coenzyme A
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acetyl-CoA + imidazole = CoA + N-acetylimidazole
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acetyl-CoA + UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate = CoA + UDP-2,3-diacetamido-2,3-dideoxy-alpha-D-glucuronate
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acetyl-CoA + fumigaclavine B = CoA + fumigaclavine A
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3 malonyl-CoA + hexanoyl-CoA = 3 CoA + 3,5,7-trioxododecanoyl-CoA + 3 CO2
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octanoyl-CoA + malonyl-[acyl-carrier protein] = 3-oxodecanoyl-[acyl-carrier protein] + CoA + CO2
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acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-glucose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-glucose
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acetyl-CoA + dTDP-4-amino-4,6-dideoxy-alpha-D-galactose = CoA + dTDP-4-acetamido-4,6-dideoxy-alpha-D-galactose
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4-coumaroyl-CoA + malonyl-CoA + H2O = 2 CoA + 4-hydroxybenzalacetone + 2 CO2
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5 malonyl-CoA = 5 CoA + 5,7-dihydroxy-2-methyl-4H-chromen-4-one + 5 CO2 + H2O
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