Literature summary for 2.3.1.9 extracted from

Huth, W.; Dierich, C.; von Oeynhausen, V.; Seubert, W.
Multiple mitochondrial forms of acetoacetyl-CoA thiolase in rat liver: possible regulatory role in ketogenesis (1974), Biochem. Biophys. Res. Commun., 56, 1069-1077.

Search for more literature for 2.3.1.9

Inhibitors

Inhibitors	Comment	Organism	Structure
acetoacetyl-CoA	isoenzyme A: above 0.015 mM, isoenzyme B: above 0.01 mM	Rattus norvegicus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.004	-	acetoacetyl-CoA	isoenzyme B, thiolysis	Rattus norvegicus
0.006	-	acetoacetyl-CoA	isoenzyme A, thiolysis	Rattus norvegicus
0.0062	-	acetyl-CoA	isoenzyme A	Rattus norvegicus
0.022	-	CoA	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
CoA + acetoacetyl-CoA	Rattus norvegicus	-	acetyl-CoA + acetyl-CoA	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	2 forms: A and B	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CoA + acetoacetyl-CoA	-	Rattus norvegicus	acetyl-CoA + acetyl-CoA	-	?
CoA + acetoacetyl-CoA	-	Rattus norvegicus	acetyl-CoA + acetyl-CoA	-	r

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0014	-	acetoacetyl-CoA	isoenzyme A	Rattus norvegicus

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Release 2023.1 (January 2023)