Information on EC 1.2.1.12 - glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
1.2.1.12
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RECOMMENDED NAME
GeneOntology No.
glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
oxidation
Phosphorylation
redox reaction
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reduction
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
Bifidobacterium shunt
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formaldehyde assimilation III (dihydroxyacetone cycle)
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gluconeogenesis I
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gluconeogenesis III
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glycerol degradation to butanol
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glycolysis I (from glucose 6-phosphate)
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glycolysis II (from fructose 6-phosphate)
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glycolysis III (from glucose)
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glycolysis IV (plant cytosol)
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heterolactic fermentation
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sucrose biosynthesis I (from photosynthesis)
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superpathway of glucose and xylose degradation
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glycolysis
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Glycolysis / Gluconeogenesis
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Carbon fixation in photosynthetic organisms
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Metabolic pathways
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Biosynthesis of secondary metabolites
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Microbial metabolism in diverse environments
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Biosynthesis of antibiotics
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SYSTEMATIC NAME
IUBMB Comments
D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)
Also acts very slowly on D-glyceraldehyde and some other aldehydes; thiols can replace phosphate.
CAS REGISTRY NUMBER
COMMENTARY hide
9001-50-7
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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Uniprot
Manually annotated by BRENDA team
strain DSM319
SwissProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
CB1809
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
containing the point mutation Q298G in the lysC gene and mutation N917G in the ppc gene
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Hippoglossus sp.
halibut
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
MG1363 and relA acid-resistant mutant
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Manually annotated by BRENDA team
commonly known as hed kradang
UniProt
Manually annotated by BRENDA team
commonly known as hed kradang
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
nonpathogenic, free-living amoeba
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
fragment
B0F3R1
UniProt
Manually annotated by BRENDA team
fragment
B0F3R1
UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
fragment
B0F3R6
UniProt
Manually annotated by BRENDA team
fragment
B0F3R6
UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
grown in mice
UniProt
Manually annotated by BRENDA team
grown in mice
UniProt
Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
antarctic psychrophilic bacterium
UniProt
Manually annotated by BRENDA team
antarctic psychrophilic bacterium
UniProt
Manually annotated by BRENDA team
Psithyrus suckleyi
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Manually annotated by BRENDA team
European pilchard
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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SwissProt
Manually annotated by BRENDA team
Group B Streptococcus
UniProt
Manually annotated by BRENDA team
TÜ469, contains pentalenolactone-insensitive glyceraldehyde-3-phosphate dehydrogenase under conditions of production of pentalenolactone. In complex medium no pentalenolactone production is observed and a pentalenolactone-sensitive D-glyceraldehyde 3-phosphate dehydrogenase, rather than the insensitive enzyme can be detected
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Manually annotated by BRENDA team
Tetrahymena pyriformis E / ATCC 30005
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Manually annotated by BRENDA team
under conditions of koningic acid production the koningic-acid-resistant isoenzyme GAPDH I is produced. In peptone-rich medium where non koningic acid is produced the koningic-acid-sensitive isoenzyme GAPDH II is produced in addition to GAPDH II
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Manually annotated by BRENDA team
GAPDH is constitutively expressed
Q4UY27
UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
3-phospho-D-glyceroyl phosphate + NADH
D-glyceraldehyde 3-phosphate + phosphate + NAD+
show the reaction diagram
3-phospho-D-glyceroyl phosphate + NADH + H+
D-glyceraldehyde 3-phosphate + phosphate + NAD+
show the reaction diagram
acetaldehyde + phosphate + NAD+
acetyl phosphate + NADH
show the reaction diagram
acetaldehyde 3-phosphate + NAD+
? + NADH
show the reaction diagram
arsenate + GSH + NAD+ + glyceraldehyde 3-phosphate
arsenite + ?
show the reaction diagram
butyraldehyde + phosphate + NAD+
butyryl phosphate + NADH
show the reaction diagram
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enzyme form E6.6 shows 10% of the activity with D-glyceraldehyde 3-phosphate, enzyme form E6.8 shows 15% of the activity with D-glyceraldehyde 3-phosphate, enzyme form E8.5 shows 12% of the actity with D-glyceraldehyde 3-phosphate, enzyme form E9.0 shows 0.9% of the activity with D-glyceraldehyde 3-phosphate
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?
D-glyceraldehyde 3-phosphate + 3-acetylpyridine hypoxanthine nucleotide + phosphate
3-phospho-D-glyceroyl phosphate + ?
show the reaction diagram
D-glyceraldehyde 3-phosphate + 3-acetylpyridine NAD+ + phosphate
3-phospho-D-glyceroyl phosphate + ?
show the reaction diagram
D-glyceraldehyde 3-phosphate + arsenate + NAD+
1-arseno-3-phosphoglycerate + NADH + H+
show the reaction diagram
D-glyceraldehyde 3-phosphate + arsenate + NAD+
3-phospho-D-glyceroyl arsenate + NADH
show the reaction diagram
D-glyceraldehyde 3-phosphate + arsenate + NAD+
3-phospho-D-glyceroyl arsenate + NADH + H+
show the reaction diagram
D-glyceraldehyde 3-phosphate + C8-(4-(2,2,6,6-tetramethyl-piperidinyl-1-oxyl))-NAD+ + phosphate
3-phospho-D-glyceroyl phosphate + C8-(4-(2,2,6,6-tetramethyl-piperidinyl-1-oxyl))-NADH
show the reaction diagram
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?
D-glyceraldehyde 3-phosphate + N6-(2-carboxyethyl)-NAD+ + phosphate
3-phospho-D-glyceroyl phosphate + N6-(2-carboxyethyl)-NADH
show the reaction diagram
D-glyceraldehyde 3-phosphate + N6-(4-(2,2,6,6-tetramethyl-piperidinyl-1-oxyl))-NAD+ + phosphate
3-phospho-D-glyceroyl phosphate + N6-(4-(2,2,6,6-tetramethyl-piperidinyl-1-oxy))-NADH
show the reaction diagram
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?
D-glyceraldehyde 3-phosphate + NAD+
D-3-phosphoglycerate + NADH
show the reaction diagram
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?
D-glyceraldehyde 3-phosphate + phosphate + NAD+
3-phospho-D-glyceroyl phosphate + NADH
show the reaction diagram
D-glyceraldehyde 3-phosphate + phosphate + NAD+
3-phospho-D-glyceroyl phosphate + NADH + H+
show the reaction diagram
D-glyceraldehyde 3-phosphate + phosphate + NADP+
3-phospho-D-glyceroyl phosphate + NADPH + H+
show the reaction diagram
D-glyceraldehyde 3-phosphate + poly(ethylene glycol)-bound NAD+ + phosphate
3-phospho-D-glyceroyl phosphate + poly(ethylene glycol)-bound NADH
show the reaction diagram
D-glyceraldehyde 3-phosphate + thio-NAD+ + phosphate
3-phospho-D-glyceroyl phosphate + thio-NADH
show the reaction diagram
DL-glyceraldehyde + phosphate + NAD+
D-glyceroyl phosphate + NADH
show the reaction diagram
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enzyme form E6.6 shows no activity, enzyme form E6.8 shows 2.5% of the activity with D-glyceraldehyde 3-phosphate, enzyme form E8.5 shows 30% of the actity with D-glyceraldehyde 3-phosphate, enzyme form E9.0 shows 3.0% of the activity with D-glyceraldehyde 3-phosphate
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?
erythrose 4-phosphate + phosphate + NAD+
? + NADH
show the reaction diagram
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enzyme form E6.6 shows no activity, enzyme form E6.8 shows 1.2% of the activity with D-glyceraldehyde 3-phosphate, enzyme form E8.5 shows 25% of the actity with D-glyceraldehyde 3-phosphate, enzyme form E9.0 shows 1.5% of the activity with D-glyceraldehyde 3-phosphate
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?
glucose + phosphate + NAD+
? + NADH
show the reaction diagram
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enzyme form E6.6 shows no activity, enzyme form E6.8 shows 0.6% of the activity with D-glyceraldehyde 3-phosphate, enzyme form E8.5 shows 6.0% of the actity with D-glyceraldehyde 3-phosphate, enzyme form E9.0 shows 0.8% of the activity with D-glyceraldehyde 3-phosphate
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?
glyceraldehyde + NAD+ + H2O
glycerate + NADH + H+
show the reaction diagram
p-nitrophenyl acetate + H2O
p-nitrophenol + acetate
show the reaction diagram
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?
propionaldehyde + phosphate + NAD+
propionyl phosphate + NADH
show the reaction diagram
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enzyme form E6.6 shows 33% of the activity with D-glyceraldehyde 3-phosphate, enzyme form E6.8 shows 12% of the activity with D-glyceraldehyde 3-phosphate, enzyme form E8.5 shows 10% of the actity with D-glyceraldehyde 3-phosphate, enzyme form E9.0 shows 0.8% of the activity with D-glyceraldehyde 3-phosphate
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?
valeraldehyde + phosphate + NAD+
pentanoyl phosphate + NADH
show the reaction diagram
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enzyme form E6.6 shows no activity, enzyme form E6.8 shows 19% of the activity with D-glyceraldehyde 3-phosphate, enzyme form E8.5 shows 18% of the actity with D-glyceraldehyde 3-phosphate, enzyme form E9.0 shows 0.9% of the activity with D-glyceraldehyde 3-phosphate
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?
additional information
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