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Literature summary for 1.2.1.12 extracted from
- Genetic, biochemical, and molecular characterization of nine glyceraldehyde-3-phosphate dehydrogenase mutants with reduced enzyme activity in Mus musculus (2007), Mamm. Genome, 18, 686-692.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| A229V | exhibits 50-55% residual activity in blood compared to the wild type enzyme | Mus musculus |
| C281W | exhibits 50-55% residual activity in blood compared to the wild type enzyme | Mus musculus |
| G166D | exhibits 50-55% residual activity in blood compared to the wild type enzyme | Mus musculus |
| I308S | exhibits 50-55% residual activity in blood compared to the wild type enzyme | Mus musculus |
| additional information | mutants Gapdhm1Neu (Y91stop truncated protein of 89 amino acids), Gapdhm2Neu (truncated/altered protein of 9 amino acids), and Gapdhm8Neu (truncated/altered protein of 73 amino acids) exhibit 50-55% residual activity in blood compared to the wild type enzyme | Mus musculus |
| V239I | exhibits 50-55% residual activity in blood compared to the wild type enzyme | Mus musculus |
| Y327N | exhibits 50-55% residual activity in blood compared to the wild type enzyme | Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 37000 | - |
4 * 37000, SDS-PAGE | Mus musculus |
| 150000 | - |
SDS-PAGE | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Mus musculus | - |
| brain | - |
Mus musculus | - |
| heart | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
| spleen | - |
Mus musculus | - |
| tail | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-glyceraldehyde 3-phosphate + phosphate + NAD+ | - |
Mus musculus | 3-phospho-D-glyceroyl phosphate + NADH + H+ | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | 4 * 37000, SDS-PAGE | Mus musculus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| D-glyceraldehyde-3-phosphate dehydrogenase | - |
Mus musculus |
| GAPDH | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | GAPDH binds four NAD+ molecules per subunit | Mus musculus | |
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Release 2023.1 (January 2023)
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