EC Number   |
Application |
Reference |
|---|
    1.2.1.12 | agriculture |
cadmium-induced stress in seedlings roots induces nitric oxide accumulation, cytosolic oxidation, activation of the GAPC1 promoter, GAPC1 protein accumulation in enzymatically inactive form, and strong relocalization of GAPC1 to the nucleus. All the effects are detected in the same zone of the root tip. In vitro, GAPC1 is inactivated by either nitric oxide donors or hydrogen peroxide, but no inhibition is directly provided by cadmium |
726233 |
| 1.2.1.12 | analysis |
GAPDH is a multi-functional protein that is used as a control marker for basal function, it is known to undergo cysteine oxidation under different types of cellular stress |
762943 |
| 1.2.1.12 | biofuel production |
proteome analysis as well as enzyme assays performed in cell-free extracts demonstrates that glycerol is degraded via glyceraldehyde-3-phosphate, which is further metabolized through the lower part of glycolysis leading to formation of mainly ethanol and hydrogen. Fermentation of glycerol to ethanol and hydrogen by this bacterium represents a remarkable option to add value to the biodiesel industries by utilization of surplus glycerol |
748573 |
| 1.2.1.12 | biotechnology |
molecular evolution or metabolic engineering protocols can exploit substrate channeling of D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and L-lactate dehydrogenase (LDH) for metabolic flux control by fine-tuning substrate-binding affinity for the key enzymes in the competing reaction paths |
762398 |
| 1.2.1.12 | drug development |
as an essential enzyme for the survival of GBS, GAPDH may be a potential target for developing antibacterial drugs |
743613 |
| 1.2.1.12 | drug development |
development of GAPDH inhibitors as anti-cancer and anti-parasitic agents |
741965 |
| 1.2.1.12 | drug development |
Gapdh can be an effective target for anti-malarial chemotherapeutics |
-, 743738 |
| 1.2.1.12 | drug development |
Gapdh can be an effective target for anti-malarial chemotherapeutics. Enzyme PfGapdh shows an extra ligand binding capacity in the vicinity of the NAD+ binding region of the active site that may offer an opportunity to design and develop novel antimalarials |
743738 |
| 1.2.1.12 | drug development |
GAPDH is an important drug target |
743755 |
| 1.2.1.12 | drug development |
the conformation of FgGAPDH in this region is similar to the human enzyme. Therefore, GAPDH may not be a suitable target for drug discovery against fascioliasis caused by Fasciola gigantica |
763540 |
