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Literature summary for 1.2.1.12 extracted from

  • Pereira, J.M.; Severino, R.P.; Vieira, P.C.; Fernandes, J.B.; da Silva, M.F.; Zottis, A.; Andricopulo, A.D.; Oliva, G.; Correa, A.G.
    Anacardic acid derivatives as inhibitors of glyceraldehyde-3-phosphate dehydrogenase from Trypanosoma cruzi (2008), Bioorg. Med. Chem., 16, 8889-8895.
    View publication on PubMed
Search for more literature for 1.2.1.12

Inhibitors

Inhibitors Comment Organism Structure
2-(dodec-1-en-1-yl)-6-hydroxybenzoic acid inhibition is not reversed or prevented by addition of Triton X-100. Noncompetitive with respect to both substrate and cofactor Trypanosoma cruzi
2-pentadecyl-6-hydroxybenzoic acid inhibition is not reversed or prevented by addition of Triton X-100. Noncompetitive with respect to both substrate and cofactor Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-glyceraldehyde 3-phosphate + phosphate + NAD+
-
 Trypanosoma cruzi 3-phospho-D-glyceroyl phosphate + NADH
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+
-
 Trypanosoma cruzi

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.002
-
 2-pentadecyl-6-hydroxybenzoic acid pH 8.9, 25°C, substrate D-glyceraldehyde 3-phosphate Trypanosoma cruzi
0.004
-
 2-(dodec-1-en-1-yl)-6-hydroxybenzoic acid pH 8.9, 25°C, substrate D-glyceraldehyde 3-phosphate Trypanosoma cruzi
0.004
-
 2-pentadecyl-6-hydroxybenzoic acid pH 8.9, 25°C, substrate NAD+ Trypanosoma cruzi
0.005
-
 2-(dodec-1-en-1-yl)-6-hydroxybenzoic acid pH 8.9, 25°C, substrate NAD+ Trypanosoma cruzi

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.028
-
 pH 8.9, 25°C Trypanosoma cruzi 2-pentadecyl-6-hydroxybenzoic acid
0.055
-
 pH 8.9, 25°C Trypanosoma cruzi 2-(dodec-1-en-1-yl)-6-hydroxybenzoic acid