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Literature summary for 1.2.1.12 extracted from

  • Komati Reddy, G.; Lindner, S.N.; Wendisch, V.F.
    Metabolic engineering of an ATP-neutral Embden-Meyerhof-Parnas pathway in Corynebacterium glutamicum: growth restoration by an adaptive point mutation in NADH dehydrogenase (2015), Appl. Environ. Microbiol., 81, 1996-2005.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum Q01651
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General Information

General Information Comment Organism
physiological function when endogenous phosphorylating NAD-dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) of Corynebacterium glutamicum is replaced by nonphosphorylating NADP-dependent glyceraldehyde-3-phosphate dehydrogenase (GapN) from Clostridium acetobutylicum, this NADPH-generating glycolytic pathway does not allow for the growth of Corynebacterium glutamicum with glucose as the sole carbon source. Heterologous expression of udhA encoding soluble transhydrogenase from Escherichia coli partly restores growth Corynebacterium glutamicum