EC Number |
Recommended Name |
Source Tissue |
Reference |
---|
3.4.23.45 | memapsin 1 |
cerebral cortex |
samples from frontal cortex of both Alzheimer's disease-affected individuals and age-matched controls. Samples show substantial total amounts of BACE2 protein and enzymatic activity. BACE2 activity does not change significantly in the brain of patients with Alzheimer's disease, and is not related to amyloid beta-peptide concentration |
712811 |
3.4.23.46 | memapsin 2 |
cerebral cortex |
- |
678539 |
3.4.23.46 | memapsin 2 |
cerebral cortex |
samples from frontal cortex of both Alzheimer's disease-affected individuals and age-matched controls. BACE1 activity shows a significant positive correlation with the amount of extractable amyloid beta-peptide, and BACE1 protein and activity are significantly increased in cases of alzheimer's disease |
712811 |
3.4.24.11 | neprilysin |
cerebral cortex |
low level of neprilysin. Amyloid-beta deposition appears in the cerebral cortex and the hippocampus |
701381 |
3.4.24.56 | insulysin |
cerebral cortex |
after the development of first amyloid beta plaques in brain of transgenic mice with alzheimer's disease-like neuropathology, cortical mRNAand protein levels of IDE are significantly up-regulated in the transgenic mice compared to their non-transgenic littermates. Up-regulation of IDE mRNA-levels occurrs in parallel with increased amyloid beta40 and amyloid beta42 production. A significant positive correlation is observed between protein levels of IDE and full-length amyloid precursor protein in the cerebral cortex |
700455 |
3.4.24.56 | insulysin |
cerebral cortex |
in Alzheimer's disease patients the protein level of insulin-degrading enzyme is decreased compared to control. However, mRNA of insulin-degrading enzyme is higher in cortex of Alzheimer's disease patients |
753340 |
3.4.24.56 | insulysin |
cerebral cortex |
isolated brain microvessels, in patients with Alzheimers disease with cerebral amyloid angiopathy enzyme protein level is up to 44% increased, but enzyme activity is significantly reduced |
667412 |
3.4.24.71 | endothelin-converting enzyme 1 |
cerebral cortex |
ECE-1 expression in Alzheimer's disease brain shows no significant difference compared with age-matched controls |
720290 |
3.4.24.B10 | ADAM12 endopeptidase |
cerebral cortex |
fetal |
670683 |
3.4.25.1 | proteasome endopeptidase complex |
cerebral cortex |
- |
688760 |
3.4.25.1 | proteasome endopeptidase complex |
cerebral cortex |
from fetal ICR mice |
711082 |
3.5.1.2 | glutaminase |
cerebral cortex |
isozymes LGA and KGA |
670391 |
3.5.3.11 | agmatinase |
cerebral cortex |
agmatinase is localised pre- and postsynaptically, to dendritic spines, spine and non-spine terminals, and dendritic profiles. In dendritic spines, labelling displayed a tendency towards the postsynaptic density |
718561 |
3.5.3.15 | protein-arginine deiminase |
cerebral cortex |
- |
695453 |
3.5.3.15 | protein-arginine deiminase |
cerebral cortex |
in neuronal cells of the cerebral cortex |
712824 |
3.5.4.37 | double-stranded RNA adenine deaminase |
cerebral cortex |
spatiotemporal expression patterns for ADAR1 and ADAR2 in mouse forebrain. ADAR1 and ADAR2 are broadly distributed in most regions of the mouse forebrain, including the cerebral cortex, hippocampus, and diencephalon. High expression levels are maintained into adulthood. ADAR1 and ADAR2 are expressed in neurons but not astrocytes. ADAR1 mRNA has its lowest expression in the choroid plexus, cortex and hippocampus, while ADAR2 mRNA is least expressed in the cortex and hippocampus, with increased expression in the thalamus |
719335 |
3.5.4.4 | adenosine deaminase |
cerebral cortex |
- |
695973, 711695 |
3.6.1.13 | ADP-ribose diphosphatase |
cerebral cortex |
- |
209946, 655991 |
3.6.1.28 | thiamine-triphosphatase |
cerebral cortex |
- |
668963 |
3.6.1.5 | apyrase |
cerebral cortex |
- |
757465 |
3.6.1.5 | apyrase |
cerebral cortex |
increase in enzymic activity from birth to day 30, decrease afterwards, highest enzymic activity at day 30, highest affinity for enzyme at day 365, relative abundance of enzyme is highest at day 15 of ontogeny |
668983 |
3.6.1.9 | nucleotide diphosphatase |
cerebral cortex |
- |
698337 |
3.6.5.2 | small monomeric GTPase |
cerebral cortex |
of E17 mice |
-, 755959 |
4.1.1.15 | glutamate decarboxylase |
cerebral cortex |
- |
-, 697807 |
4.1.1.19 | arginine decarboxylase |
cerebral cortex |
presence of both arginine decarboxylase and arginase in principal neurons and putative interneurons |
728614 |
4.1.1.22 | histidine decarboxylase |
cerebral cortex |
- |
716351 |
4.1.2.13 | fructose-bisphosphate aldolase |
cerebral cortex |
- |
651759 |
4.1.2.13 | fructose-bisphosphate aldolase |
cerebral cortex |
isoenzyme III, IV, and V |
4948 |
4.1.3.4 | hydroxymethylglutaryl-CoA lyase |
cerebral cortex |
- |
693782 |
4.3.2.1 | argininosuccinate lyase |
cerebral cortex |
- |
708319 |
4.3.2.9 | gamma-glutamylcyclotransferase |
cerebral cortex |
weak expression |
720332 |
4.4.1.5 | lactoylglutathione lyase |
cerebral cortex |
- |
682102 |
4.6.1.1 | adenylate cyclase |
cerebral cortex |
- |
691561 |
4.6.1.1 | adenylate cyclase |
cerebral cortex |
ACIII localizes to cilia in adults, throughout the cortex, including the subiculum, as well as the retrosplenial granular, visual, motor, and orbital cortices |
-, 681092 |
4.6.1.2 | guanylate cyclase |
cerebral cortex |
all neocortical areas with high expression of all subunits, expression of the three subunits in all cortical layers, alpha1 subunit enriched in layer VI |
681090 |
4.6.1.2 | guanylate cyclase |
cerebral cortex |
beta1 subunit mRNA widely distributed through all cortical areas and cell layers with higher intensity in layer V, alpha2 mRNA homogeneously distributed through all cortical layers and alpha1 expression higher in layers IIIII and V |
681090 |
5.1.1.13 | aspartate racemase |
cerebral cortex |
- |
706558, 728034 |
5.1.1.18 | serine racemase |
cerebral cortex |
- |
-, 706540, 726664, 728034 |
5.1.1.18 | serine racemase |
cerebral cortex |
glial culture from |
663264 |
5.1.1.18 | serine racemase |
cerebral cortex |
pyramidal neuron of cerebral cortex and hippocampal CA1 region, predominant localization |
693369 |
5.6.1.1 | microtubule-severing ATPase |
cerebral cortex |
- |
675537, 699690 |
5.6.1.2 | dynein ATPase |
cerebral cortex |
- |
669959 |
5.6.2.1 | DNA topoisomerase |
cerebral cortex |
neuron |
3800 |
6.1.1.18 | glutamine-tRNA ligase |
cerebral cortex |
- |
743985 |
6.1.1.2 | tryptophan-tRNA ligase |
cerebral cortex |
about 0.2% of total soluble protein |
306 |
6.2.1.16 | acetoacetate-CoA ligase |
cerebral cortex |
in cerebral cortex expression of AACS mRNA is restricetd to neuronal cells |
661256 |
6.2.1.4 | succinate-CoA ligase (GDP-forming) |
cerebral cortex |
- |
745246 |
6.3.1.2 | glutamine synthetase |
cerebral cortex |
- |
692128 |
6.3.2.24 | tyrosine-arginine ligase |
cerebral cortex |
- |
-, 745971 |
6.3.2.41 | N-acetylaspartylglutamate synthase |
cerebral cortex |
- |
728179 |
7.1.1.2 | NADH:ubiquinone reductase (H+-translocating) |
cerebral cortex |
- |
692231 |
7.1.1.9 | cytochrome-c oxidase |
cerebral cortex |
- |
686054 |
7.1.1.9 | cytochrome-c oxidase |
cerebral cortex |
frontal cortex and posterior cortex |
695205 |
7.1.1.9 | cytochrome-c oxidase |
cerebral cortex |
regular alternation of areas with high and low levels of activity of the respiratory enzyme CO in layers III, IV, and VI of field 17 and in layers IV and VII of field 18 of the cerebral cortex |
694377 |
7.2.2.13 | Na+/K+-exchanging ATPase |
cerebral cortex |
- |
246958, 246966, 688017, 690001, 695408, 700430, 701165 |