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Literature summary for 3.5.3.15 extracted from

  • Shimada, N.; Handa, S.; Uchida, Y.; Fukuda, M.; Maruyama, N.; Asaga, H.; Choi, E.K.; Lee, J.; Ishigami, A.
    Developmental and age-related changes of peptidylarginine deiminase 2 in the mouse brain (2010), J. Neurosci. Res., 88, 798-806.
    View publication on PubMed
Search for more literature for 3.5.3.15

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
 SDS-PAGE Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein L-Arg + H2O Mus musculus
-
 protein L-citrulline + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
cerebellum in Purkinje cells of the cerebellum Mus musculus
-
cerebral cortex in neuronal cells of the cerebral cortex Mus musculus
-
hippocampus
-
 Mus musculus
-
medulla oblongata
-
 Mus musculus
-
midbrain
-
 Mus musculus
-
olfactory bulb
-
 Mus musculus
-
pons
-
 Mus musculus
-
spinal cord
-
 Mus musculus
-
thalamus
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein L-Arg + H2O
-
 Mus musculus protein L-citrulline + NH3
-
 ?

Subunits

Subunits Comment Organism
? x * 75000, SDS-PAGE Mus musculus

Synonyms

Synonyms Comment Organism
PAD2
-
 Mus musculus
peptidylarginine deiminase 2
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus PAD2 mRNA expression is detected in the brains of mice as early as embryonic day 15, and its expression in cerebral cortex, hippocampus, and cerebellum increases significantly as the animals age from 3 to 30 months old, PAD2 mRNA levels in the cerebral cortex, cerebellum, and hippocampus at 30 months were about 1.6fold,1.5fold, and 1.6fold higher, respectively, than in 3-month-old animals up

General Information

General Information Comment Organism
physiological function despite PAD2's normally inactive status, it becomes active and citrullinates cellular proteins, but only when the intracellular Ca2+ balance is upset during neurodegenerative changes. Abnormal protein citrullination by PAD2 is closely associated with the pathogenesis of neurodegenerative disorders such as Alzheimer’s disease and prion disease Mus musculus