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Information on EC 3.5.4.37 - double-stranded RNA adenine deaminase

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IUBMB Comments
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity .
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Word Map
  • 3.5.4.37
  • editing
  • inosine
  • deaminases
  • a-to-i
  • deamination
  • pre-mrnas
  • hereditaria
  • rna-editing
  • symmetrica
  • adenosine-to-inosine
  • dyschromatosis
  • ampa
  • duplex
  • left-handed
  • interferon-inducible
  • hypopigmented
  • site-selective
  • unedited
  • macules
  • glur-b
  • recoding
  • dsrbds
  • interferonopathy
  • dsrna-binding
  • trna-specific
  • glutamate-gated
  • hyperediting
  • antigenome
  • interferon-stimulated
  • pigmentary
  • ca2+-permeable
  • ifn-stimulated
  • genodermatosis
  • inosine-containing
  • samhd1
  • hypermutation
  • ifn-inducible
  • 5-ht2cr
The enzyme appears in viruses and cellular organisms
Reaction Schemes
adenine in double-stranded RNA
+
=
hypoxanthine in double-stranded RNA
+
Synonyms
adar1, adar2, dsrad, dadar, double-stranded rna adenosine deaminase, double-stranded rna-specific adenosine deaminase, adenosine deaminase acting on rna 1, ciadar1, dsrna adenosine deaminase, drada1, more
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
adenine in double-stranded RNA + H2O = hypoxanthine in double-stranded RNA + NH3
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