Cloned (Comment) | Organism |
---|---|
expression as a thioredoxin fusion protein in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
F- | IC50: 0.02 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.06 | - |
ADP-ribose | pH 7.5, 37°C | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | optimal activity with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+ | Homo sapiens | |
Mn2+ | optimal activity with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+ | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
24300 | - |
2 * 24300, native protein, mass spectrometry | Homo sapiens |
85000 | - |
dimeric thioredoxin fusion protein expressed in Escherichia coli, gel filtration | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP-ribose + H2O | Homo sapiens | the function of the enzyme might be to remove free ADP-ribose arising from NAD+ and protein-bound poly- and non-enzymic protein glycation | AMP + ribose 5-phosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UKK9 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
adrenal gland | - |
Homo sapiens | - |
aorta | - |
Homo sapiens | - |
bladder | - |
Homo sapiens | - |
bone marrow | low activity | Homo sapiens | - |
brain | - |
Homo sapiens | - |
caudate nucleus | - |
Homo sapiens | - |
caudate putamen | - |
Homo sapiens | - |
cerebellum | - |
Homo sapiens | - |
cerebral cortex | - |
Homo sapiens | - |
colon | - |
Homo sapiens | - |
frontal lobe | - |
Homo sapiens | - |
heart | - |
Homo sapiens | - |
hippocampus | - |
Homo sapiens | - |
kidney | high activity | Homo sapiens | - |
leukocyte | - |
Homo sapiens | - |
liver | high activity | Homo sapiens | - |
lung | - |
Homo sapiens | - |
lymph node | low activity | Homo sapiens | - |
mammary gland | - |
Homo sapiens | - |
medulla oblongata | - |
Homo sapiens | - |
nucleus accumbens | - |
Homo sapiens | - |
occipital lobe | - |
Homo sapiens | - |
ovary | - |
Homo sapiens | - |
pancreas | - |
Homo sapiens | - |
peripheral blood | - |
Homo sapiens | - |
pituitary gland | high activity | Homo sapiens | - |
placenta | high activity | Homo sapiens | - |
prostate | - |
Homo sapiens | - |
salivary gland | - |
Homo sapiens | - |
skeletal muscle | - |
Homo sapiens | - |
small intestine | - |
Homo sapiens | - |
spinal cord | - |
Homo sapiens | - |
spleen | - |
Homo sapiens | - |
stomach | - |
Homo sapiens | - |
substantia nigra | - |
Homo sapiens | - |
temporal lobe | - |
Homo sapiens | - |
testis | - |
Homo sapiens | - |
thalamus | - |
Homo sapiens | - |
thymus | high activity | Homo sapiens | - |
thyroid gland | - |
Homo sapiens | - |
trachea | - |
Homo sapiens | - |
uterus | - |
Homo sapiens | - |
vermiform appendix | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ADP-glucose + H2O | 56% of the activity with ADP-ribose | Homo sapiens | AMP + alpha-D-glucose 1-phosphate | - |
? | |
ADP-mannose + H2O | 103% of the activity with ADP-ribose | Homo sapiens | AMP + D-mannose 1-phosphate | - |
? | |
ADP-ribose + H2O | - |
Homo sapiens | AMP + ribose 5-phosphate | - |
? | |
ADP-ribose + H2O | the function of the enzyme might be to remove free ADP-ribose arising from NAD+ and protein-bound poly- and non-enzymic protein glycation | Homo sapiens | AMP + ribose 5-phosphate | - |
? | |
diadenosine 5',5''-diphosphate + H2O | 20% the activity with ADP-ribose | Homo sapiens | ? | - |
? | |
GDP-glucose + H2O | 7% of the activity with ADP-ribose | Homo sapiens | GMP + glucose 5-phosphate | - |
? | |
IDP-ribose + H2O | 9% of the activity with ADP-ribose | Homo sapiens | IMP + ribose 5-phosphate | - |
? | |
NAD+ + H2O | 7% of the activity with ADP-ribose | Homo sapiens | AMP + NMN | - |
? | |
NADH + H2O | 7% of the activity with ADP-ribose | Homo sapiens | AMP + NMNH | - |
? | |
NADPH + H2O | 12% of the activity with ADP-ribose | Homo sapiens | AMP + ? | - |
? | |
UDP-galactose + H2O | 7% of the activity with ADP-ribose | Homo sapiens | UDP + galactose | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 24300, native protein, mass spectrometry | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
adenosine 5'-diphosphosugar pyrophosphatase | - |
Homo sapiens |
YSA1H | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
5.5 | - |
ADP-ribose | pH 7.5, 37°C | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | 9 | with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+ | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.02 | - |
IC50: 0.02 mM | Homo sapiens | F- |