BRENDA - Enzyme Database
show all sequences of 3.6.1.13

Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif

Gasmi, L.; Cartwright, J.L.; McLennan, A.G.; Biochem. J. 344, 331-337 (1999)

Data extracted from this reference:

Cloned(Commentary)
Commentary
Organism
expression as a thioredoxin fusion protein in Escherichia coli
Homo sapiens
Inhibitors
Inhibitors
Commentary
Organism
Structure
F-
IC50: 0.02 mM
Homo sapiens
KM Value [mM]
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.06
-
ADP-ribose
pH 7.5, 37°C
Homo sapiens
Metals/Ions
Metals/Ions
Commentary
Organism
Structure
Mg2+
optimal activity with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+
Homo sapiens
Mn2+
optimal activity with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+
Homo sapiens
Molecular Weight [Da]
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
24300
-
2 * 24300, native protein, mass spectrometry
Homo sapiens
85000
-
dimeric thioredoxin fusion protein expressed in Escherichia coli, gel filtration
Homo sapiens
Natural Substrates/ Products (Substrates)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ADP-ribose + H2O
Homo sapiens
the function of the enzyme might be to remove free ADP-ribose arising from NAD+ and protein-bound poly- and non-enzymic protein glycation
AMP + ribose 5-phosphate
-
-
?
Organism
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
Homo sapiens
Q9UKK9
-
-
Purification (Commentary)
Commentary
Organism
-
Homo sapiens
Source Tissue
Source Tissue
Commentary
Organism
Textmining
adrenal gland
-
Homo sapiens
-
aorta
-
Homo sapiens
-
bladder
-
Homo sapiens
-
bone marrow
low activity
Homo sapiens
-
brain
-
Homo sapiens
-
caudate nucleus
-
Homo sapiens
-
caudate putamen
-
Homo sapiens
-
cerebellum
-
Homo sapiens
-
cerebral cortex
-
Homo sapiens
-
colon
-
Homo sapiens
-
frontal lobe
-
Homo sapiens
-
heart
-
Homo sapiens
-
hippocampus
-
Homo sapiens
-
kidney
high activity
Homo sapiens
-
leukocyte
-
Homo sapiens
-
liver
high activity
Homo sapiens
-
lung
-
Homo sapiens
-
lymph node
low activity
Homo sapiens
-
mammary gland
-
Homo sapiens
-
medulla oblongata
-
Homo sapiens
-
nucleus accumbens
-
Homo sapiens
-
occipital lobe
-
Homo sapiens
-
ovary
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
peripheral blood
-
Homo sapiens
-
pituitary gland
high activity
Homo sapiens
-
placenta
high activity
Homo sapiens
-
prostate
-
Homo sapiens
-
salivary gland
-
Homo sapiens
-
skeletal muscle
-
Homo sapiens
-
small intestine
-
Homo sapiens
-
spinal cord
-
Homo sapiens
-
spleen
-
Homo sapiens
-
stomach
-
Homo sapiens
-
substantia nigra
-
Homo sapiens
-
temporal lobe
-
Homo sapiens
-
testis
-
Homo sapiens
-
thalamus
-
Homo sapiens
-
thymus
high activity
Homo sapiens
-
thyroid gland
-
Homo sapiens
-
trachea
-
Homo sapiens
-
uterus
-
Homo sapiens
-
vermiform appendix
-
Homo sapiens
-
Substrates and Products (Substrate)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ADP-glucose + H2O
56% of the activity with ADP-ribose
209946
Homo sapiens
AMP + alpha-D-glucose 1-phosphate
-
-
-
?
ADP-mannose + H2O
103% of the activity with ADP-ribose
209946
Homo sapiens
AMP + D-mannose 1-phosphate
-
-
-
?
ADP-ribose + H2O
-
209946
Homo sapiens
AMP + ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
the function of the enzyme might be to remove free ADP-ribose arising from NAD+ and protein-bound poly- and non-enzymic protein glycation
209946
Homo sapiens
AMP + ribose 5-phosphate
-
-
-
?
diadenosine 5',5''-diphosphate + H2O
20% the activity with ADP-ribose
209946
Homo sapiens
?
-
-
-
?
GDP-glucose + H2O
7% of the activity with ADP-ribose
209946
Homo sapiens
GMP + glucose
-
-
-
?
IDP-ribose + H2O
9% of the activity with ADP-ribose
209946
Homo sapiens
IMP + ribose 5-phosphate
-
-
-
?
NAD+ + H2O
7% of the activity with ADP-ribose
209946
Homo sapiens
AMP + NMN
-
-
-
?
NADH + H2O
7% of the activity with ADP-ribose
209946
Homo sapiens
AMP + NMNH
-
-
-
?
NADPH + H2O
12% of the activity with ADP-ribose
209946
Homo sapiens
AMP + ?
-
-
-
?
UDP-galactose + H2O
7% of the activity with ADP-ribose
209946
Homo sapiens
UDP + galactose
-
-
-
?
Subunits
Subunits
Commentary
Organism
dimer
2 * 24300, native protein, mass spectrometry
Homo sapiens
Turnover Number [1/s]
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
5.5
-
ADP-ribose
pH 7.5, 37°C
Homo sapiens
pH Optimum
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
9
with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+
Homo sapiens
IC50 Value
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.02
-
IC50: 0.02 mM
Homo sapiens
F-
Cloned(Commentary) (protein specific)
Commentary
Organism
expression as a thioredoxin fusion protein in Escherichia coli
Homo sapiens
IC50 Value (protein specific)
IC50 Value
IC50 Value Maximum
Commentary
Organism
Inhibitor
Structure
0.02
-
IC50: 0.02 mM
Homo sapiens
F-
Inhibitors (protein specific)
Inhibitors
Commentary
Organism
Structure
F-
IC50: 0.02 mM
Homo sapiens
KM Value [mM] (protein specific)
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
0.06
-
ADP-ribose
pH 7.5, 37°C
Homo sapiens
Metals/Ions (protein specific)
Metals/Ions
Commentary
Organism
Structure
Mg2+
optimal activity with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+
Homo sapiens
Mn2+
optimal activity with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+
Homo sapiens
Molecular Weight [Da] (protein specific)
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
24300
-
2 * 24300, native protein, mass spectrometry
Homo sapiens
85000
-
dimeric thioredoxin fusion protein expressed in Escherichia coli, gel filtration
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
ADP-ribose + H2O
Homo sapiens
the function of the enzyme might be to remove free ADP-ribose arising from NAD+ and protein-bound poly- and non-enzymic protein glycation
AMP + ribose 5-phosphate
-
-
?
Purification (Commentary) (protein specific)
Commentary
Organism
-
Homo sapiens
Source Tissue (protein specific)
Source Tissue
Commentary
Organism
Textmining
adrenal gland
-
Homo sapiens
-
aorta
-
Homo sapiens
-
bladder
-
Homo sapiens
-
bone marrow
low activity
Homo sapiens
-
brain
-
Homo sapiens
-
caudate nucleus
-
Homo sapiens
-
caudate putamen
-
Homo sapiens
-
cerebellum
-
Homo sapiens
-
cerebral cortex
-
Homo sapiens
-
colon
-
Homo sapiens
-
frontal lobe
-
Homo sapiens
-
heart
-
Homo sapiens
-
hippocampus
-
Homo sapiens
-
kidney
high activity
Homo sapiens
-
leukocyte
-
Homo sapiens
-
liver
high activity
Homo sapiens
-
lung
-
Homo sapiens
-
lymph node
low activity
Homo sapiens
-
mammary gland
-
Homo sapiens
-
medulla oblongata
-
Homo sapiens
-
nucleus accumbens
-
Homo sapiens
-
occipital lobe
-
Homo sapiens
-
ovary
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
peripheral blood
-
Homo sapiens
-
pituitary gland
high activity
Homo sapiens
-
placenta
high activity
Homo sapiens
-
prostate
-
Homo sapiens
-
salivary gland
-
Homo sapiens
-
skeletal muscle
-
Homo sapiens
-
small intestine
-
Homo sapiens
-
spinal cord
-
Homo sapiens
-
spleen
-
Homo sapiens
-
stomach
-
Homo sapiens
-
substantia nigra
-
Homo sapiens
-
temporal lobe
-
Homo sapiens
-
testis
-
Homo sapiens
-
thalamus
-
Homo sapiens
-
thymus
high activity
Homo sapiens
-
thyroid gland
-
Homo sapiens
-
trachea
-
Homo sapiens
-
uterus
-
Homo sapiens
-
vermiform appendix
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
ADP-glucose + H2O
56% of the activity with ADP-ribose
209946
Homo sapiens
AMP + alpha-D-glucose 1-phosphate
-
-
-
?
ADP-mannose + H2O
103% of the activity with ADP-ribose
209946
Homo sapiens
AMP + D-mannose 1-phosphate
-
-
-
?
ADP-ribose + H2O
-
209946
Homo sapiens
AMP + ribose 5-phosphate
-
-
-
?
ADP-ribose + H2O
the function of the enzyme might be to remove free ADP-ribose arising from NAD+ and protein-bound poly- and non-enzymic protein glycation
209946
Homo sapiens
AMP + ribose 5-phosphate
-
-
-
?
diadenosine 5',5''-diphosphate + H2O
20% the activity with ADP-ribose
209946
Homo sapiens
?
-
-
-
?
GDP-glucose + H2O
7% of the activity with ADP-ribose
209946
Homo sapiens
GMP + glucose
-
-
-
?
IDP-ribose + H2O
9% of the activity with ADP-ribose
209946
Homo sapiens
IMP + ribose 5-phosphate
-
-
-
?
NAD+ + H2O
7% of the activity with ADP-ribose
209946
Homo sapiens
AMP + NMN
-
-
-
?
NADH + H2O
7% of the activity with ADP-ribose
209946
Homo sapiens
AMP + NMNH
-
-
-
?
NADPH + H2O
12% of the activity with ADP-ribose
209946
Homo sapiens
AMP + ?
-
-
-
?
UDP-galactose + H2O
7% of the activity with ADP-ribose
209946
Homo sapiens
UDP + galactose
-
-
-
?
Subunits (protein specific)
Subunits
Commentary
Organism
dimer
2 * 24300, native protein, mass spectrometry
Homo sapiens
Turnover Number [1/s] (protein specific)
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
5.5
-
ADP-ribose
pH 7.5, 37°C
Homo sapiens
pH Optimum (protein specific)
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
7.4
9
with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+
Homo sapiens
Other publictions for EC 3.6.1.13
No.
1st author
Pub Med
title
organims
journal
volume
pages
year
Activating Compound
Application
Cloned(Commentary)
Crystallization (Commentary)
Engineering
General Stability
Inhibitors
KM Value [mM]
Localization
Metals/Ions
Molecular Weight [Da]
Natural Substrates/ Products (Substrates)
Organic Solvent Stability
Organism
Oxidation Stability
Posttranslational Modification
Purification (Commentary)
Reaction
Renatured (Commentary)
Source Tissue
Specific Activity [micromol/min/mg]
Storage Stability
Substrates and Products (Substrate)
Subunits
Temperature Optimum [°C]
Temperature Range [°C]
Temperature Stability [°C]
Turnover Number [1/s]
pH Optimum
pH Range
pH Stability
Cofactor
Ki Value [mM]
pI Value
IC50 Value
Activating Compound (protein specific)
Application (protein specific)
Cloned(Commentary) (protein specific)
Cofactor (protein specific)
Crystallization (Commentary) (protein specific)
Engineering (protein specific)
General Stability (protein specific)
IC50 Value (protein specific)
Inhibitors (protein specific)
Ki Value [mM] (protein specific)
KM Value [mM] (protein specific)
Localization (protein specific)
Metals/Ions (protein specific)
Molecular Weight [Da] (protein specific)
Natural Substrates/ Products (Substrates) (protein specific)
Organic Solvent Stability (protein specific)
Oxidation Stability (protein specific)
Posttranslational Modification (protein specific)
Purification (Commentary) (protein specific)
Renatured (Commentary) (protein specific)
Source Tissue (protein specific)
Specific Activity [micromol/min/mg] (protein specific)
Storage Stability (protein specific)
Substrates and Products (Substrate) (protein specific)
Subunits (protein specific)
Temperature Optimum [°C] (protein specific)
Temperature Range [°C] (protein specific)
Temperature Stability [°C] (protein specific)
Turnover Number [1/s] (protein specific)
pH Optimum (protein specific)
pH Range (protein specific)
pH Stability (protein specific)
pI Value (protein specific)
Expression
General Information
General Information (protein specific)
Expression (protein specific)
KCat/KM [mM/s]
KCat/KM [mM/s] (protein specific)
735009
Cabezas
Molecular bases of catalysis a ...
Homo sapiens
PLoS ONE
10
e0118680
2015
-
-
-
1
13
-
-
42
-
-
-
-
-
7
-
-
-
-
-
-
-
-
4
-
-
-
-
44
-
-
-
-
-
-
-
-
-
-
-
1
13
-
-
-
-
42
-
-
-
-
-
-
-
-
-
-
-
-
4
-
-
-
-
44
-
-
-
-
-
-
-
-
54
54
734285
Karuppiah
Structure and mechanism of the ...
Thermus thermophilus, Thermus thermophilus DSM 579
J. Biol. Chem.
289
33187-33197
2014
-
-
-
1
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
718517
Okazaki
Crystallization and preliminar ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Acta Crystallogr. Sect. F
68
49-52
2012
-
-
1
1
-
-
-
-
1
2
-
-
-
5
-
-
1
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
1
2
-
-
-
-
-
1
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
735057
Rodrigues
Characterization of Danio reri ...
Danio rerio
PLoS ONE
7
e42249
2012
-
-
-
1
1
-
-
13
-
1
-
-
-
4
-
-
-
-
-
-
-
-
8
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
13
-
1
-
-
-
-
-
-
-
-
-
-
8
-
-
-
-
13
-
-
-
-
-
-
-
-
13
13
715407
Ito
Cleavage of oxidized guanine n ...
Homo sapiens
J. Biochem.
149
731-738
2011
-
-
1
-
-
-
5
4
-
-
-
-
-
3
-
-
1
-
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
5
-
4
-
-
-
-
-
-
-
1
-
-
-
-
3
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
741073
Arimori
Diverse substrate recognition ...
Homo sapiens
Nucleic Acids Res.
39
8972-8983
2011
-
-
1
1
-
-
-
-
-
1
-
1
-
2
-
-
1
-
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
720769
Ishikawa
Distinct regulation of Arabido ...
Arabidopsis thaliana
Plant Signal. Behav.
5
839-841
2010
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
1
1
1
1
-
-
700755
Ogawa
Overexpression of an ADP-ribos ...
Arabidopsis thaliana
Plant J.
57
289-301
2009
-
-
-
-
-
-
-
-
-
-
2
-
-
2
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
1
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
710725
Goncalves
Structure of an N-terminally t ...
Deinococcus radiodurans
Acta Crystallogr. Sect. F
65
1083-1087
2009
-
-
1
1
-
-
-
-
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
1
-
-
-
1
-
1
-
-
-
-
-
-
-
-
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
-
-
-
-
-
687404
Wakamatsu
Structural basis for different ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
J. Bacteriol.
190
1108-1117
2008
-
-
1
1
-
-
-
4
-
1
-
4
-
6
-
-
1
-
-
-
-
-
8
-
1
-
-
4
1
1
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
4
-
1
-
4
-
-
-
1
-
-
-
-
8
-
1
-
-
4
1
1
-
-
-
-
-
-
-
-
688413
Zha
Molecular mechanism of ADP-rib ...
Homo sapiens
J. Mol. Biol.
379
568-578
2008
-
-
1
1
20
-
-
22
1
1
-
2
-
3
-
-
1
1
-
-
-
-
4
1
1
-
-
21
1
-
-
-
-
-
-
-
-
2
-
2
30
-
-
-
-
22
1
1
-
2
-
-
-
1
-
-
-
-
4
1
1
-
-
21
1
-
-
-
-
-
-
-
20
20
690090
Huang
Bifunctional NMN adenylyltrans ...
Francisella tularensis, Synechocystis sp.
Structure
16
196-209
2008
-
-
2
2
-
-
-
-
-
2
-
2
-
6
-
-
2
2
-
-
-
-
6
2
2
-
-
-
2
-
-
-
-
-
-
-
-
2
-
2
-
-
-
-
-
-
-
2
-
2
-
-
-
2
-
-
-
-
6
2
2
-
-
-
2
-
-
-
-
-
-
-
-
-
684834
Yu
Activation of NUDT5, an ADP-ri ...
Homo sapiens
Biochem. Biophys. Res. Commun.
354
764-768
2007
1
-
1
-
-
-
-
-
-
1
-
1
-
2
-
-
1
-
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
2
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
690189
Ge
AcMNPV ORF38 protein has the a ...
Autographa californica multiple nucleopolyhedrovirus
Virology
361
204-211
2007
-
-
1
-
-
-
-
1
-
1
-
1
-
3
-
-
1
-
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
1
-
1
-
1
-
-
-
1
-
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
667823
Carloto
The specific, submicromolar-K( ...
Homo sapiens
Biochim. Biophys. Acta
1760
1545-1551
2006
-
-
-
-
-
-
2
-
-
4
1
1
-
2
-
-
1
-
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
4
1
1
-
-
-
1
-
2
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
670632
Jambunathan
Analysis of Arabidopsis growth ...
Arabidopsis sp.
Planta
224
1-11
2006
-
-
-
-
-
-
-
1
-
-
-
-
-
4
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
715902
Zha
Crystal structures of human NU ...
Homo sapiens
J. Mol. Biol.
364
1021-1033
2006
-
-
1
1
-
-
-
-
-
1
-
1
-
3
-
-
1
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
1
-
-
-
1
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
667690
Ooga
Molecular mechanism of the The ...
Thermus thermophilus
Biochemistry
44
9320-9329
2005
-
-
-
1
21
-
1
22
-
-
-
-
-
3
-
-
1
-
-
-
-
-
4
-
-
-
-
29
-
-
-
-
2
-
-
-
-
-
-
1
21
-
-
1
2
22
-
-
-
-
-
-
-
1
-
-
-
-
4
-
-
-
-
29
-
-
-
-
-
-
-
-
-
-
669102
Okuda
Systematic characterization of ...
Synechocystis sp.
J. Bacteriol.
187
4984-4991
2005
-
-
1
-
-
-
-
3
-
1
-
1
-
3
-
-
1
-
-
-
-
-
4
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
3
-
1
-
1
-
-
-
1
-
-
-
-
4
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
669355
Ogawa
Comprehensive analysis of cyto ...
Arabidopsis thaliana
J. Biol. Chem.
280
25277-25283
2005
-
-
1
-
-
-
-
4
1
-
-
-
-
7
-
-
1
-
-
3
-
-
4
-
-
-
-
3
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
4
1
-
-
-
-
-
-
1
-
3
-
-
4
-
-
-
-
3
-
-
-
-
-
-
-
-
-
-
654895
Okuda
Identification and characteriz ...
Synechococcus sp.
Biochim. Biophys. Acta
1699
245-252
2004
-
-
1
-
-
-
-
1
-
3
3
-
-
4
-
-
1
-
-
-
-
-
2
1
-
-
-
1
1
1
-
-
-
1
-
-
-
1
-
-
-
-
-
-
-
1
-
3
3
-
-
-
-
1
-
-
-
-
2
1
-
-
-
1
1
1
-
1
-
-
-
-
-
-
656238
Yoshiba
Structural insights into the T ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
J. Biol. Chem.
279
37163-37174
2004
-
-
-
1
6
-
-
10
-
-
-
2
-
92
-
-
-
-
-
-
-
-
5
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
-
1
6
-
-
-
-
10
-
-
-
2
-
-
-
-
-
-
-
-
5
-
-
-
-
9
-
-
-
-
-
-
-
-
-
-
654079
Yoshiba
Overproduction, crystallizatio ...
Thermus thermophilus, Thermus thermophilus HB8 / ATCC 27634 / DSM 579
Acta Crystallogr. Sect. D
59
1840-1842
2003
-
-
1
1
-
-
-
-
-
2
1
-
-
6
-
-
1
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
2
1
-
-
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
656126
Perraud
NUDT9, a member of the Nudix h ...
Homo sapiens
J. Biol. Chem.
278
1794-1801
2003
-
-
-
-
-
-
-
-
1
2
2
-
-
2
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
2
-
-
-
-
-
-
-
-
-
1
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
654662
Gabelli
Mechanism of the Escherichia c ...
Escherichia coli
Biochemistry
41
9279-9285
2002
-
-
-
-
-
-
-
-
-
1
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
740674
Rafty
Analysis of O-acetyl-ADP-ribos ...
Mus musculus
J. Biol. Chem.
277
47114-47122
2002
-
-
-
-
-
-
-
2
-
-
-
1
-
4
-
-
-
-
-
1
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
1
-
-
2
-
-
-
-
2
-
-
-
-
-
-
-
-
2
2
654805
Ribeiro
Human placenta hydrolases acti ...
Homo sapiens
Biochim. Biophys. Acta
1526
86-94
2001
-
-
-
-
-
-
2
1
-
2
-
1
-
2
-
-
1
-
-
2
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
1
-
2
-
1
-
-
-
1
-
2
-
-
4
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
654833
Lin
Cloning, expression and charac ...
Homo sapiens
Biochim. Biophys. Acta
1594
127-135
2001
-
-
1
-
-
-
2
1
-
2
1
-
-
3
-
-
-
-
-
-
-
-
2
1
-
-
-
1
1
-
-
-
-
-
-
-
-
1
-
-
-
-
-
2
-
1
-
2
1
-
-
-
-
-
-
-
-
-
2
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
656856
Gabelli
The structure of ADP-ribose py ...
Escherichia coli
Nat. Struct. Biol.
8
467-472
2001
-
-
-
1
-
-
-
-
-
-
-
-
-
2
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
655991
Yang
Cloning and characterization o ...
Homo sapiens, Mus musculus
J. Biol. Chem.
275
8844-8853
2000
-
-
2
-
-
-
-
4
-
6
2
-
-
5
-
-
2
-
-
57
-
-
17
2
-
-
-
-
3
3
-
-
-
2
-
-
-
2
-
-
-
-
-
-
-
4
-
6
2
-
-
-
-
2
-
57
-
-
17
2
-
-
-
-
3
3
-
2
-
-
-
-
-
-
209865
Dunn
Studies on the ADP-ribose pyro ...
Bacillus subtilis, Escherichia coli, Haemophilus influenzae, Methanocaldococcus jannaschii, Rhodobacter sphaeroides, Saccharomyces cerevisiae
J. Biol. Chem.
274
32318-32324
1999
-
-
4
-
-
-
-
5
-
-
-
6
-
12
-
-
-
-
-
-
-
-
20
-
-
-
-
5
-
-
-
-
-
-
-
-
-
4
-
-
-
-
-
-
-
5
-
-
-
6
-
-
-
-
-
-
-
-
20
-
-
-
-
5
-
-
-
-
-
-
-
-
-
-
209870
Ribeiro
ADP-ribose pyrophosphatase-I p ...
Rattus norvegicus
J. Biochem. Mol. Toxicol.
13
171-177
1999
-
-
-
-
-
-
1
1
-
-
-
-
-
2
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
-
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209946
Gasmi
Cloning, expression and charac ...
Homo sapiens
Biochem. J.
344
331-337
1999
-
-
1
-
-
-
1
1
-
2
2
1
-
4
-
-
1
-
-
43
-
-
11
1
-
-
-
1
1
-
-
-
-
-
1
-
-
1
-
-
-
-
1
1
-
1
-
2
2
1
-
-
-
1
-
43
-
-
11
1
-
-
-
1
1
-
-
-
-
-
-
-
-
-
209863
Sheikh
Identification and characteriz ...
Methanocaldococcus jannaschii
J. Biol. Chem.
273
20924-20928
1998
-
-
1
-
-
-
-
2
-
1
-
-
-
5
-
-
1
-
-
1
-
-
2
-
-
1
2
2
-
-
-
-
-
-
-
-
-
1
-
-
-
-
-
-
-
2
-
1
-
-
-
-
-
1
-
1
-
-
2
-
-
1
2
2
-
-
-
-
-
-
-
-
-
-
209864
Kim
Purification and characterizat ...
Homo sapiens
Int. J. Biochem. Cell Biol.
30
629-638
1998
-
-
-
-
-
-
1
1
-
-
2
1
-
2
-
-
1
-
-
-
1
1
9
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
1
-
-
2
1
-
-
-
1
-
-
1
1
9
1
-
-
-
-
1
-
-
-
-
-
-
-
-
-
209869
Ribeiro
Rat liver ADP-ribose pyrophosp ...
Rattus norvegicus
Biochim. Biophys. Acta
1336
403-4o8
1997
-
-
-
-
-
-
1
2
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
2
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209867
Fernandez
Specific ADP-ribose pyrophosph ...
Artemia sp., Rattus norvegicus
Biochim. Biophys. Acta
1290
121-127
1996
-
-
-
-
-
-
4
1
-
4
1
-
-
4
-
-
1
-
-
4
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4
-
1
-
4
1
-
-
-
-
1
-
4
1
-
4
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209866
Ribeiro
Inhibition of ADP-ribose pyrop ...
Rattus norvegicus
Biochem. Biophys. Res. Commun.
213
1075-1081
1995
-
-
-
-
-
-
3
1
-
-
-
-
-
2
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
1
-
-
-
-
-
-
-
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209868
Canales
Rat liver nucleoside diphospho ...
Rattus norvegicus
Biochim. Biophys. Acta
1246
167-177
1995
-
-
-
-
-
-
-
3
-
2
3
-
-
2
-
-
1
-
-
2
3
-
8
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3
-
2
3
-
-
-
-
1
-
2
3
-
8
-
-
-
-
-
2
-
-
-
-
-
-
-
-
-
209862
Bernet
Rat liver mitochondrial ADP-ri ...
Rattus norvegicus
Biochem. J.
299
679-682
1994
-
-
-
-
-
-
-
1
2
2
1
-
-
2
-
-
1
-
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
2
2
1
-
-
-
-
1
-
2
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209859
Kim
Adenosine diphosphate ribose p ...
Homo sapiens
J. Dermatol.
7
11-15
1980
-
-
-
-
-
-
2
-
-
1
-
-
-
2
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
2
-
-
-
1
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
209860
Wu
Catabolism of NAD+ in rabbit r ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
520
588-597
1978
-
-
-
-
-
-
13
-
-
-
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
13
-
-
-
-
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
209861
Doherty
The hydrolysis of adenosine di ...
Oryctolagus cuniculus
Biochim. Biophys. Acta
65
364-366
1962
-
-
-
-
-
-
-
1
-
3
-
-
-
1
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
1
-
3
-
-
-
-
-
-
-
1
-
-
1
-
-
-
-
-
1
-
-
-
-
-
-
-
-
-