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Literature summary for 3.6.1.13 extracted from

  • Gasmi, L.; Cartwright, J.L.; McLennan, A.G.
    Cloning, expression and characterization of YSA1H, a human adenosine 5'-diphosphosugar pyrophosphatase possessing a MutT motif (1999), Biochem. J., 344, 331-337.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression as a thioredoxin fusion protein in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
F- IC50: 0.02 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.06
-
ADP-ribose pH 7.5, 37°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ optimal activity with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+ Homo sapiens
Mn2+ optimal activity with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+ Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
24300
-
2 * 24300, native protein, mass spectrometry Homo sapiens
85000
-
dimeric thioredoxin fusion protein expressed in Escherichia coli, gel filtration Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP-ribose + H2O Homo sapiens the function of the enzyme might be to remove free ADP-ribose arising from NAD+ and protein-bound poly- and non-enzymic protein glycation AMP + ribose 5-phosphate
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UKK9
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
Homo sapiens
-
aorta
-
Homo sapiens
-
bladder
-
Homo sapiens
-
bone marrow low activity Homo sapiens
-
brain
-
Homo sapiens
-
caudate nucleus
-
Homo sapiens
-
caudate putamen
-
Homo sapiens
-
cerebellum
-
Homo sapiens
-
cerebral cortex
-
Homo sapiens
-
colon
-
Homo sapiens
-
frontal lobe
-
Homo sapiens
-
heart
-
Homo sapiens
-
hippocampus
-
Homo sapiens
-
kidney high activity Homo sapiens
-
leukocyte
-
Homo sapiens
-
liver high activity Homo sapiens
-
lung
-
Homo sapiens
-
lymph node low activity Homo sapiens
-
mammary gland
-
Homo sapiens
-
medulla oblongata
-
Homo sapiens
-
nucleus accumbens
-
Homo sapiens
-
occipital lobe
-
Homo sapiens
-
ovary
-
Homo sapiens
-
pancreas
-
Homo sapiens
-
peripheral blood
-
Homo sapiens
-
pituitary gland high activity Homo sapiens
-
placenta high activity Homo sapiens
-
prostate
-
Homo sapiens
-
salivary gland
-
Homo sapiens
-
skeletal muscle
-
Homo sapiens
-
small intestine
-
Homo sapiens
-
spinal cord
-
Homo sapiens
-
spleen
-
Homo sapiens
-
stomach
-
Homo sapiens
-
substantia nigra
-
Homo sapiens
-
temporal lobe
-
Homo sapiens
-
testis
-
Homo sapiens
-
thalamus
-
Homo sapiens
-
thymus high activity Homo sapiens
-
thyroid gland
-
Homo sapiens
-
trachea
-
Homo sapiens
-
uterus
-
Homo sapiens
-
vermiform appendix
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP-glucose + H2O 56% of the activity with ADP-ribose Homo sapiens AMP + alpha-D-glucose 1-phosphate
-
?
ADP-mannose + H2O 103% of the activity with ADP-ribose Homo sapiens AMP + D-mannose 1-phosphate
-
?
ADP-ribose + H2O
-
Homo sapiens AMP + ribose 5-phosphate
-
?
ADP-ribose + H2O the function of the enzyme might be to remove free ADP-ribose arising from NAD+ and protein-bound poly- and non-enzymic protein glycation Homo sapiens AMP + ribose 5-phosphate
-
?
diadenosine 5',5''-diphosphate + H2O 20% the activity with ADP-ribose Homo sapiens ?
-
?
GDP-glucose + H2O 7% of the activity with ADP-ribose Homo sapiens GMP + glucose 5-phosphate
-
?
IDP-ribose + H2O 9% of the activity with ADP-ribose Homo sapiens IMP + ribose 5-phosphate
-
?
NAD+ + H2O 7% of the activity with ADP-ribose Homo sapiens AMP + NMN
-
?
NADH + H2O 7% of the activity with ADP-ribose Homo sapiens AMP + NMNH
-
?
NADPH + H2O 12% of the activity with ADP-ribose Homo sapiens AMP + ?
-
?
UDP-galactose + H2O 7% of the activity with ADP-ribose Homo sapiens UDP + galactose
-
?

Subunits

Subunits Comment Organism
dimer 2 * 24300, native protein, mass spectrometry Homo sapiens

Synonyms

Synonyms Comment Organism
adenosine 5'-diphosphosugar pyrophosphatase
-
Homo sapiens
YSA1H
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.5
-
ADP-ribose pH 7.5, 37°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4 9 with 2.5-5 mM Mg2+ or 0.1-0.25 mM Mn2+ Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.02
-
IC50: 0.02 mM Homo sapiens F-