Literature summary for 3.4.24.56 extracted from

Vepsaelaeinen, S.; Hiltunen, M.; Helisalmi, S.; Wang, J.; van Groen, T.; Tanila, H.; Soininen, H.
Increased expression of Abeta degrading enzyme IDE in the cortex of transgenic mice with Alzheimers disease-like neuropathology (2008), Neurosci. Lett., 438, 216-220.

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Application

Application	Comment	Organism
medicine	after the development of first amyloid beta plaques in brain of transgenic mice with alzheimer's disease-like neuropathology, cortical mRNAand protein levels of IDE are significantly up-regulated in the transgenic mice compared to their non-transgenic littermates. Up-regulation of IDE mRNA-levels occurrs in parallel with increased amyloid beta40 and amyloid beta42 production. A significant positive correlation is observed between protein levels of IDE and full-length amyloid precursor protein in the cerebral cortex	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	transgenic mice with Alzheimer's disease-like neuropathology	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
cerebral cortex	after the development of first amyloid beta plaques in brain of transgenic mice with alzheimer's disease-like neuropathology, cortical mRNAand protein levels of IDE are significantly up-regulated in the transgenic mice compared to their non-transgenic littermates. Up-regulation of IDE mRNA-levels occurrs in parallel with increased amyloid beta40 and amyloid beta42 production. A significant positive correlation is observed between protein levels of IDE and full-length amyloid precursor protein in the cerebral cortex	Mus musculus	-

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Release 2023.1 (January 2023)