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Literature summary for 4.6.1.1 extracted from

  • Slotkin, T.A.; Ryde, I.T.; Mackillop, E.A.; Bodwell, B.E.; Seidler, F.J.
    Adolescent nicotine administration changes the responses to nicotine given subsequently in adulthood: adenylyl cyclase cell signaling in brain regions during nicotine administration and withdrawal, and lasting effects (2008), Brain Res. Bull., 76, 522-530.
    View publication on PubMed
Search for more literature for 4.6.1.1

Activating Compound

Activating Compound Comment Organism Structure
forskolin forskolin activation is elevated by nicotine treatment in adolescence, especially in males Rattus norvegicus
Nicotine nicotine treatment in adulthood produces an immediate increase in adenylate cyclase activity in males that disappears upon withdrawal, nicotine increases the activating effect of forskolin, especially in males, overview Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Rattus norvegicus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP Rattus norvegicus the adenylyl cyclase signaling cascade is involved in nicotine dependence and withdrawal, but also mediates numerous other neurotransmitter responses, effects of nicotine on adenylate cyclase enzyme activity: adolescent nicotine exposure elicits persistent suppression of basal adenylate cyclase activity and eventual compromise of responses to beta-adrenergic receptor stimulation, with effects emerging in late adulthood, overview 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Rattus norvegicus
-
brain stem
-
 Rattus norvegicus
-
cerebellum
-
 Rattus norvegicus
-
cerebral cortex
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?
ATP the adenylyl cyclase signaling cascade is involved in nicotine dependence and withdrawal, but also mediates numerous other neurotransmitter responses, effects of nicotine on adenylate cyclase enzyme activity: adolescent nicotine exposure elicits persistent suppression of basal adenylate cyclase activity and eventual compromise of responses to beta-adrenergic receptor stimulation, with effects emerging in late adulthood, overview Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Rattus norvegicus