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Information on EC 3.1.2.2 - palmitoyl-CoA hydrolase
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3.1.2.2 palmitoyl-CoA hydrolaseIUBMB Comments
Also hydrolyses CoA thioesters of other long-chain fatty acids.
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Word Map
- 3.1.2.2
- acyl-coas
- polyketide
- thioesters
-
nonribosomal
- acyltransferase
- synthetases
-
cyclization
- palmitate
- acyl-acps
-
macrocyclization
-
medium-chain
-
beta-oxidation
-
6-deoxyerythronolide
-
enoyl
-
beta-ketoacyl
-
macrolactone
-
nrpss
-
depalmitoylation
- malonyl-coa
- coash
- 4'-phosphopantetheine
-
tyrocidine
- orlistat
- palmitoyl-protein
- lipofuscinosis
- cuphea
-
transacylase
-
surfactin
-
ceroid
-
chain-length
-
uropygial
-
s-acylated
-
ketosynthase
-
chain-terminating
-
didomains
- 4-chlorobenzoate
- enterobactin
- saccharopolyspora
-
12-membered
- phosphopantetheine
- biotechnology
- n-acetylcysteamine
- ketoreductase
-
acyl-carrier
- myristoyl-coa
-
off-loading
- erythraea
- mallard
-
macrolactamization
-
offload
-
triketide
The enzyme appears in viruses and cellular organisms
Synonyms
thioesterase, palmitoyl-coa hydrolase, acot7, thioesterase ii, acot1, type ii fas, acot2, thioesterase i, mte-i, cte-i, 
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SYNONYM 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
ACH1
-
-
-
-
ACH2
Acot1
ACOT2
Acot7
ACT
-
-
-
-
acyl CoA hydrolase
-
-
-
-
acyl coenzyme A hydrolase
-
-
-
-
acyl coenzyme A thioesterase
-
-
-
-
acyl-CoA hydrolase
acyl-CoA thioesterase
acyl-CoA thioesterase 7
BACH
brain acyl-CoA hydrolase
CTE-I
EC 3.1.2.20
-
-
related
-
eFAS
fatty acyl thioesterase I
-
-
-
-
FcoT
HIV-Nef associated acyl coA thioesterase
-
-
-
-
hydrolase, acyl coenzyme A
-
-
-
-
hydrolase, palmitoyl coenzyme A
-
-
-
-
LACH1
-
-
-
-
LACH2
-
-
-
-
long chain acyl-CoA hydrolase
-
-
-
-
long chain acyl-CoA thioesterase
long chain fatty-acyl-CoA hydrolase
-
-
-
-
long chain fatty-acyl-CoA thioesterase
-
-
-
-
long-chain acyl-CoA thioesterase
long-chain fatty acyl-CoA thioesterase
mitochondrial acyl-CoA thioesterase
-
-
-
-
MTE-I
Orf6 thioesterase
palmitoyl coenzyme A hydrolase
-
-
-
-
palmitoyl protein thioesterase-1
palmitoyl thioesterase
-
-
-
-
palmitoyl-CoA deacylase
-
-
-
-
palmitoyl-CoA hydrolase
-
-
-
-
palmityl coenzyme A deacylase
-
-
-
-
palmityl thioesterase
-
-
-
-
palmityl thioesterase I
-
-
-
-
palmityl thioesterase II
-
-
-
-
peroxisomal acyl-CoA thioesterase 2
PPT1
PTE-2
PTE-Ia
PTE-Ib
TE
-
-
-
-
TE-II
-
-
-
-
TesA
thioesterase B
-
-
-
-
thioesterase I
thioesterase I/protease I/lysophospholipase L1
multifunctional enzyme with thioesterase, esterase, arylesterase, protease and lysophospholipase activities
thioesterase II
-
-
-
-
type II FAS
type II fatty acid synthase
very long chain acyl-CoA thioesterase
-
-
-
-
ZAP128
additional information
ACH2
-
-
-
-
acyl-CoA thioesterase
-
-
-
-
brain acyl-CoA hydrolase
-
-
-
-
long chain acyl-CoA thioesterase
-
-
-
-
thioesterase I
multifunctional enzyme with thioesterase, esterase, arylesterase, protease and lysophospholipase activities
ZAP128
-
-
-
-
additional information
-
immunologically not related with the thioesterase of fatty acid synthase or the acyl fatty acid synthase thioester hydrolase
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REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
palmitoyl-CoA + H2O = CoA + palmitate
-
-
-
-
palmitoyl-CoA + H2O = CoA + palmitate
catalytic triad D337-Q409-S359
Q8GYW7
palmitoyl-CoA + H2O = CoA + palmitate
specific catalyzation of the deacylation of long-chain fatty acyl-CoA thioesters, enzyme possesses a Ser-His-Asp catalytic triad
-
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REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
hydrolysis of thioester
hydrolysis of thioester
-
-
-
-
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PATHWAY SOURCE
PATHWAYS
BRENDA
KEGG
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SYSTEMATIC NAME
IUBMB Comments
palmitoyl-CoA hydrolase
Also hydrolyses CoA thioesters of other long-chain fatty acids.
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CAS REGISTRY NUMBER
COMMENTARY
37270-64-7
EC 3.1.2.2
9025-87-0
-
9025-87-0
EC 3.1.2.20
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SUBSTRATE
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
2-nitrophenyl acetate + H2O
2-nitrophenol + acetate
synthetic substrate
-
-
?
3-hydroxy-3-methyl glutaryl-CoA + H2O
CoA + 3-hydroxy-3-methyl glutarate
-
-
-
?
3-hydroxy-3-methylglutaryl-CoA + H2O
CoA + 3-hydroxy-3-methylglutarate
-
-
?
3-hydroxybutyryl-CoA + H2O
CoA + 3-hydroxybutanoate
-
reaction at 4.3% the rate of acetoacetyl-CoA hydrolysis
-
-
?
butyryl-[acyl-carrier protein] + H2O
butanoate + acyl-carrier protein
-
-
-
?
cis-methylene-9,10-hexadecanoyl-CoA + H2O
CoA + cis-methylene-9,10-hexadecanoate
-
-
-
?
malonyl-CoA + H2O
malonate + CoA
-
-
-
?
N-carbobenzoxy-L-tyrosine p-nitrophenyl ester + H2O
N-carbobenzoxy-L-tyrosine + p-nitrophenol
-
-
-
?
p-nitrophenyl butyrate + H2O
p-nitrophenol + butanoate
-
-
-
?
palmitoyl-CoA + H2O
palmitate + CoA
-
-
-
?
propionyl-[acyl-carrier protein] + H2O
propionate + acyl-carrier protein
-
-
-
?
succinyl-CoA + H2O
CoA + succinate
-
reaction at 33% the rate of acetoacetyl-CoA hydrolysis
-
-
?
tetradecylthioacetyl-CoA + H2O
CoA + tetradecylthioacetate
-
best substrate
-
-
?
trihydroxycoprostanoyl-CoA + H2O
CoA + trihydroxycoprostanoate
-
-
?
3-hydroxydecanoyl-CoA + H2O
CoA + 3-hydroxydecanoate
-
reaction at 1.4% the rate of acetoacetyl-CoA hydrolysis
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
-
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
involved in pristanic acid beta-oxidation, scheme of the pathway
-
?
4,8-dimethylnonanoyl-CoA + H2O
CoA + 4,8-dimethylnonanoate
hydrolysis allows transport of 4,8-dimethylnonanoate from peroxisomes to mitochondria for full oxidation
-
?
acetoacetyl-CoA + H2O
CoA + acetoacetate
-
8% activity compared to palmitoyl-CoA
-
?
acetyl-CoA + H2O
CoA + acetate
-
reaction at 33% the rate of acetoacetyl-CoA hydrolysis
-
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
Q8GYW7
prefers unsaturated acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
Q8GYW7
long-chain fatty-acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
Q8GYW7
enzyme is not linked to fatty acid oxidation
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
saturated and unsaturated acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate
-
broad specificity for medium-chain to long-chain acyl-CoA
-
?
acyl-CoA + H2O
CoA + a carboxylate