Literature summary for 3.1.2.2 extracted from

Kim, S.J.; Zhang, Z.; Sarkar, C.; Tsai, P.C.; Lee, Y.C.; Dye, L.; Mukherjee, A.B.
Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice (2008), J. Clin. Invest., 118, 3075-3086.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Mus musculus	PPT1-knockout mice, PPT1 deficiency causes persistent membrane anchorage of the palmitoylated synaptic vesicle proteins, which hinder the recycling of the vesicle components that normally fuse with the presynaptic plasma membrane during synaptic vesicle exocytosis	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P50897	-	-
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	PPT1 is localized in the presynaptic compartment	Mus musculus	-
brain	PPT1 is localized in the presynaptic compartment and is most likely associated with the synaptosomes and synaptic vesicles. PPT1 deficiency causes an abnormally low level of synaptic vesicle proteins in the soluble fractions of the postmortem brain tissues from an infantile neuronal ceroid lipofuscinosis patient	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	PPT1-knockout mice, PPT1 deficiency causes persistent membrane anchorage of the palmitoylated synaptic vesicle proteins, which hinder the recycling of the vesicle components that normally fuse with the presynaptic plasma membrane during synaptic vesicle exocytosis	Mus musculus	?	-	?

Synonyms

Synonyms	Comment	Organism
palmitoyl protein thioesterase-1	-	Mus musculus
palmitoyl protein thioesterase-1	-	Homo sapiens
PPT1	-	Mus musculus
PPT1	-	Homo sapiens

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Release 2023.1 (January 2023)