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Literature summary for 3.1.2.2 extracted from

  • Hunt, M.C.; Rautanen, A.; Westin, M.A.; Svensson, L.T.; Alexson, S.E.
    Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs (2006), FASEB J., 20, 1855-1864.
    View publication on PubMed
Search for more literature for 3.1.2.2

Cloned(Commentary)

Cloned (Comment) Organism
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
 tetradecanoyl-CoA
-
 Homo sapiens
0.002
-
 hexadecanoyl-CoA
-
 Homo sapiens
0.002
-
 eicosanoyl-CoA
-
 Homo sapiens
0.0024
-
 palmitoleoyl-CoA
-
 Homo sapiens
0.0024
-
 octadecanoyl-CoA
-
 Homo sapiens
0.0028
-
 tetradecanoyl-CoA
-
 Homo sapiens
0.0028
-
 octadecanoyl-CoA
-
 Homo sapiens
0.0036
-
 hexadecanoyl-CoA
-
 Homo sapiens
0.0036
-
 dodecanoyl-CoA
-
 Homo sapiens
0.0041
-
 oleoyl-CoA
-
 Homo sapiens
0.0045
-
 palmitoleoyl-CoA
-
 Homo sapiens
0.0048
-
 eicosanoyl-CoA
-
 Homo sapiens
0.0061
-
 oleoyl-CoA
-
 Homo sapiens
0.0358
-
 decanoyl-CoA
-
 Homo sapiens
0.0403
-
 decanoyl-CoA
-
 Homo sapiens
0.089
-
 dodecanoyl-CoA
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P49753
-
-
Homo sapiens Q86TX2
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart strong expression Homo sapiens
-
heart strong expression. ACOT2 is much more strongly expressed than ACOT1 Homo sapiens
-
kidney strong expression Homo sapiens
-
liver strong expression Homo sapiens
-
liver strong expression. ACOT2 is much more strongly expressed than ACOT1 Homo sapiens
-
muscle strong expression Homo sapiens
-
muscle strong expression. ACOT2 is much more strongly expressed than ACOT1 Homo sapiens
-
pancreas weak expression Homo sapiens
-
placenta weak expression Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
decanoyl-CoA + H2O
-
 Homo sapiens CoA + decanoate
-
 ?
dodecanoyl-CoA + H2O
-
 Homo sapiens CoA + dodecanoate
-
 ?
eicosanoyl-CoA + H2O
-
 Homo sapiens CoA + eicosanoic acid
-
 ?
hexadecanoyl-CoA + H2O
-
 Homo sapiens CoA + hexadecanoate
-
 ?
octadecanoyl-CoA + H2O
-
 Homo sapiens CoA + octadecanoate
-
 ?
oleoyl-CoA + H2O
-
 Homo sapiens CoA + oleic acid
-
 ?
palmitoleoyl-CoA + H2O
-
 Homo sapiens CoA + palmitoleic acid
-
 ?
tetradecanoyl-CoA + H2O
-
 Homo sapiens CoA + tetradecanoate
-
 ?

Synonyms

Synonyms Comment Organism
Acot1
-
 Homo sapiens
ACOT2
-
 Homo sapiens
acyl-CoA thioesterase 1
-
 Homo sapiens
acyl-CoA thioesterase 2
-
 Homo sapiens
acyl-coenzyme A thioester hydrolase 2a
-
 Homo sapiens
CTE-I
-
 Homo sapiens
CTE-Ia
-
 Homo sapiens
CTE-Ib
-
 Homo sapiens
long-chain acyl-CoA thioesterase 2
-
 Homo sapiens
ZAP128
-
 Homo sapiens