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Literature summary for 3.1.2.2 extracted from

  • Moffat, C.; Bhatia, L.; Nguyen, T.; Lynch, P.; Wang, M.; Wang, D.; Ilkayeva, O.; Han, X.; Hirschey, M.; Claypool, S.; Seifert, E.
    Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver (2015), J. Lipid Res., 55, 2458-2470 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.1.2.2

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0033
-
 palmitoyl-CoA at pH 7.6 and 37°C Mus musculus
0.0033
-
 myristoyl-CoA at pH 7.6 and 37°C Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acyl-CoA + H2O Mus musculus
-
 CoA + a carboxylate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus Q9QYR9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
hepatocyte
-
 Mus musculus
-
liver
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acyl-CoA + H2O
-
 Mus musculus CoA + a carboxylate
-
 ?
linoleoyl-CoA + H2O
-
 Mus musculus CoA + linoleate
-
 ?
additional information no activity with octanoyl-CoA Mus musculus ?
-
 ?
myristoyl-CoA + H2O
-
 Mus musculus CoA + myristate
-
 ?
oleoyl-CoA + H2O
-
 Mus musculus CoA + oleate
-
 ?
palmitoyl-CoA + H2O
-
 Mus musculus CoA + palmitate
-
 ?

Synonyms

Synonyms Comment Organism
ACOT2
-
 Mus musculus
acyl-CoA thioesterase-2
-
 Mus musculus

General Information

General Information Comment Organism
metabolism the enzyme enhances fatty acid oxidation, possibly by mitigating the accumulation of fatty acid oxidation intermediates within the mitochondrial matrix. The enzyme increases proton leak in liver mitochondria Mus musculus