Reference on EC 3.5.3.15 - protein-arginine deiminase and Organism(s) Homo sapiens
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AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Pritzker, L.B.; Joshi, S.; Harauz, G.; Moscarello, M.A.
Deimination of myelin basic protein 3.5.3.15. Effect of methylation of MBP on its deimination by peptidylarginine deiminase
Biochemistry
39
5382-5388
2000
Bos taurus, Homo sapiens
Arita, K.; Hashimoto, H.; Shimizu, T.; Yamada, M.; Sato, M.
Crystallization and preliminary X-ray crystallographic analysis of human peptidylarginine deiminase V
Acta Crystallogr. Sect. D
59
2332-2333
2003
Homo sapiens
Arita, K.; Hashimoto, H.; Shimizu, T.; Nakashima, K.; Yamada, M.; Sato, M.
Structural basis for Ca2+-induced activation of human PAD4
Nat. Struct. Mol. Biol.
11
777-783
2004
Homo sapiens (Q9UM07), Homo sapiens
Zhang, J.; Dai, J.; Zhao, E.; Lin, Y.; Zeng, L.; Chen, J.; Zheng, H.; Wang, Y.; Li, X.; Ying, K.; Xie, Y.; Mao, Y.
cDNA cloning, gene organization and expression analysis of human peptidylarginine deiminase type VI
Acta Biochim. Pol.
51
1051-1058
2004
Homo sapiens
Vossenaar, E.R.; Radstake, T.R.; van der Heijden, A.; van Mansum, M.A.; Dieteren, C.; de Rooij, D.J.; Barrera, P.; Zendman, A.J.; van Venrooij, W.J.
Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages
Ann. Rheum. Dis.
63
373-381
2004
Homo sapiens (Q9Y2J8), Homo sapiens
Sambandam, T.; Belousova, M.; Accaviti-Loper, M.A.; Blanquicett, C.; Guercello, V.; Raijmakers, R.; Nicholas, A.P.
Increased peptidylarginine deiminase type II in hypoxic astrocytes
Biochem. Biophys. Res. Commun.
325
1324-1329
2004
Homo sapiens (Q9Y2J8), Homo sapiens
Nakayama-Hamada, M.; Suzuki, A.; Kubota, K.; Takazawa, T.; Ohsaka, M.; Kawaida, R.; Ono, M.; Kasuya, A.; Furukawa, H.; Yamada, R.; Yamamoto, K.
Comparison of enzymatic properties between hPADI2 and hPADI4
Biochem. Biophys. Res. Commun.
327
192-200
2005
Homo sapiens
Dong, S.; Kanno, T.; Yamaki, A.; Kojima, T.; Shiraiwa, M.; Kawada, A.; Mechin, M.C.; Chavanas, S.; Serre, G.; Simon, M.; Takahara, H.
NF-Y and Sp1/Sp3 are involved in the transcriptional regulation of the peptidylarginine deiminase type III gene (PADI3) in human keratinocytes
Biochem. J.
397
449-459
2006
Homo sapiens (Q9ULW8), Homo sapiens
Kearney, P.L.; Bhatia, M.; Jones, N.G.; Yuan, L.; Glascock, M.C.; Catchings, K.L.; Yamada, M.; Thompson, P.R.
Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis
Biochemistry
44
10570-10582
2005
Homo sapiens (Q9UM07), Homo sapiens
Stone, E.M.; Schaller, T.H.; Bianchi, H.; Person, M.D.; Fast, W.
Inactivation of two diverse enzymes in the amidinotransferase superfamily by 2-chloroacetamidine: dimethylargininase and peptidylarginine deiminase
Biochemistry
44
13744-13752
2005
Homo sapiens (Q9UM07), Homo sapiens
Hagiwara, T.; Hidaka, Y.; Yamada, M.
Deimination of histone H2A and H4 at arginine 3 in HL-60 granulocytes
Biochemistry
44
5827-5834
2005
Homo sapiens
Cuthbert, G.L.; Daujat, S.; Snowden, A.W.; Erdjument-Bromage, H.; Hagiwara, T.; Yamada, M.; Schneider, R.; Gregory, P.D.; Tempst, P.; Bannister, A.J.; Kouzarides, T.
Histone deimination antagonizes arginine methylation
Cell
118
545-553
2004
Homo sapiens
Mechin, M.C.; Enji, M.; Nachat, R.; Chavanas, S.; Charveron, M.; Ishida-Yamamoto, A.; Serre, G.; Takahara, H.; Simon, M.
The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations
Cell. Mol. Life Sci.
62
1984-1995
2005
Homo sapiens, Homo sapiens (Q9ULC6), Homo sapiens (Q9ULW8)
Hidaka, Y.; Hagiwara, T.; Yamada, M.
Methylation of the guanidino group of arginine residues prevents citrullination by peptidylarginine deiminase IV
FEBS Lett.
579
4088-4092
2005
Homo sapiens (Q9UM07)
Nachat, R.; Mechin, M.C.; Takahara, H.; Chavanas, S.; Charveron, M.; Serre, G.; Simon, M.
Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin
J. Invest. Dermatol.
124
384-393
2005
Homo sapiens (Q9ULC6), Homo sapiens (Q9ULW8), Homo sapiens (Q9Y2J8), Homo sapiens
Nachat, R.; Mechin, M.C.; Charveron, M.; Serre, G.; Constans, J.; Simon, M.
Peptidylarginine deiminase isoforms are differentially expressed in the anagen hair follicles and other human skin appendages
J. Invest. Dermatol.
125
34-41
2005
Homo sapiens, Homo sapiens (Q9ULW8), Homo sapiens (Q9Y2J8)
Ishigami, A.; Ohsawa, T.; Hiratsuka, M.; Taguchi, H.; Kobayashi, S.; Saito, Y.; Murayama, S.; Asaga, H.; Toda, T.; Kimura, N.; Maruyama, N.
Abnormal accumulation of citrullinated proteins catalyzed by peptidylarginine deiminase in hippocampal extracts from patients with Alzheimer's disease
J. Neurosci. Res.
80
120-128
2005
Homo sapiens
Chang, X.; Han, J.
Expression of peptidylarginine deiminase type 4 (PAD4) in various tumors
Mol. Carcinog.
45
183-196
2006
Homo sapiens (Q9UM07)
Arita, K.; Shimizu, T.; Hashimoto, H.; Hidaka, Y.; Yamada, M.; Sato, M.
Structural basis for histone N-terminal recognition by human peptidylarginine deiminase 4
Proc. Natl. Acad. Sci. USA
103
5291-5296
2006
Homo sapiens, Homo sapiens (Q9UM07)
Kubota, K.; Yoneyama-Takazawa, T.; Ichikawa, K.
Determination of sites citrullinated by peptidylarginine deiminase using 18O stable isotope labeling and mass spectrometry
Rapid Commun. Mass Spectrom.
19
683-688
2005
Homo sapiens
Chang, X.; Yamada, R.; Suzuki, A.; Sawada, T.; Yoshino, S.; Tokuhiro, S.; Yamamoto, K.
Localization of peptidylarginine deiminase 4 (PADI4) and citrullinated protein in synovial tissue of rheumatoid arthritis
Rheumatology
44
40-50
2005
Homo sapiens
Harney, S.M.; Meisel, C.; Sims, A.M.; Woon, P.Y.; Wordsworth, B.P.; Brown, M.A.
Genetic and genomic studies of PADI4 in rheumatoid arthritis
Rheumatology
44
869-872
2005
Homo sapiens
Wang, Y.; Wysocka, J.; Sayegh, J.; Lee, Y.H.; Perlin, J.R.; Leonelli, L.; Sonbuchner, L.S.; McDonald, C.H.; Cook, R.G.; Dou, Y.; Roeder, R.G.; Clarke, S.; Stallcup, M.R.; Allis, C.D.; Coonrod, S.A.
Human PAD4 regulates histone arginine methylation levels via demethylimination
Science
306
279-283
2004
Homo sapiens
Zendman, A.J.; Raijmakers, R.; Nijenhuis, S.; Vossenaar, E.R.; Tillaart, M.; Chirivi, R.G.; Raats, J.M.; van Venrooij, W.J.; Drijfhout, J.W.; Pruijn, G.J.
ABAP: antibody-based assay for peptidylarginine deiminase activity
Anal. Biochem.
369
232-240
2007
Oryctolagus cuniculus, Mus musculus, Homo sapiens (Q9Y2J8), Homo sapiens, Mus musculus C57BL/6 / 129S
Hung, H.C.; Lin, C.Y.; Liao, Y.F.; Hsu, P.C.; Tsay, G.J.; Liu, G.Y.
The functional haplotype of peptidylarginine deiminase IV (S55G, A82V and A112G) associated with susceptibility to rheumatoid arthritis dominates apoptosis of acute T leukemia Jurkat cells
Apoptosis
12
475-487
2007
Homo sapiens
Luo, Y.; Arita, K.; Bhatia, M.; Knuckley, B.; Lee, Y.H.; Stallcup, M.R.; Sato, M.; Thompson, P.R.
Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization
Biochemistry
45
11727-11736
2006
Homo sapiens (Q9UM07)
Knuckley, B.; Luo, Y.; Thompson, P.R.
Profiling protein arginine deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors
Bioorg. Med. Chem.
16
739-745
2008
Homo sapiens
Keilhoff, G.; Prell, T.; Langnaese, K.; Mawrin, C.; Simon, M.; Fansa, H.; Nicholas, A.P.
Expression pattern of peptidylarginine deiminase in rat and human Schwann cells
Dev. Neurobiol.
68
101-114
2007
Homo sapiens, Homo sapiens (Q9ULC6), Homo sapiens (Q9Y2J8), Rattus norvegicus
Algeciras, M.E.; Bhattacharya, S.K.
Targeting optic nerve citrullination in glaucoma: a role for protein-arginine deiminase 2 (PAD2) inhibitors
Drugs Future
32
999-1005
2007
Homo sapiens, Homo sapiens (Q6TGC4), Homo sapiens (Q9ULC6), Homo sapiens (Q9ULW8), Homo sapiens (Q9Y2J8), Rattus norvegicus, Rattus norvegicus (O88806), Rattus norvegicus (O88807), Rattus norvegicus (P20717), Rattus norvegicus (P70708)
-
Dong, S.; Ying, S.; Kojima, T.; Shiraiwa, M.; Kawada, A.; Mechin, M.C.; Adoue, V.; Chavanas, S.; Serre, G.; Simon, M.; Takahara, H.
Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes
J. Invest. Dermatol.
128
549-557
2008
Homo sapiens (Q9ULC6), Homo sapiens
Wood, D.D.; Ackerley, C.A.; Brand, B.; Zhang, L.; Raijmakers, R.; Mastronardi, F.G.; Moscarello, M.A.
Myelin localization of peptidylarginine deiminases 2 and 4: comparison of PAD2 and PAD4 activities
Lab. Invest.
88
354-364
2008
Homo sapiens, Mus musculus (Q08642), Mus musculus (Q9Z183), Mus musculus CD-1 (Q08642), Mus musculus CD-1 (Q9Z183)
Makrygiannakis, D.; Hermansson, M.; Ulfgren, A.K.; Nicholas, A.P.; Zendman, A.J.; Eklund, A.; Grunewald, J.; Skold, C.M.; Klareskog, L.; Catrina, A.I.
Smoking increases peptidylarginine deiminase 2 enzyme expression in human lungs and increases citrullination in BAL cells
Ann. Rheum. Dis.
67
1488-1492
2008
Homo sapiens
Musse, A.A.; Polverini, E.; Raijmakers, R.; Harauz, G.
Kinetics of human peptidylarginine deiminase 2 (hPAD2)--reduction of Ca2+ dependence by phospholipids and assessment of proposed inhibition by paclitaxel side chains
Biochem. Cell Biol.
86
437-447
2008
Homo sapiens
Stensland, M.E.; Pollmann, S.; Molberg, ?.; Sollid, L.M.; Fleckenstein, B.
Primary sequence, together with other factors, influence peptide deimination by peptidylarginine deiminase-4
Biol. Chem.
390
99-107
2009
Homo sapiens
Loos, T.; Mortier, A.; Gouwy, M.; Ronsse, I.; Put, W.; Lenaerts, J.P.; Van Damme, J.; Proost, P.
Citrullination of CXCL10 and CXCL11 by peptidylarginine deiminase: a naturally occurring posttranslational modification of chemokines and new dimension of immunoregulation
Blood
112
2648-2656
2008
Oryctolagus cuniculus, Homo sapiens
Musse, A.A.; Li, Z.; Ackerley, C.A.; Bienzle, D.; Lei, H.; Poma, R.; Harauz, G.; Moscarello, M.A.; Mastronardi, F.G.
Peptidylarginine deiminase 2 (PAD2) overexpression in transgenic mice leads to myelin loss in the central nervous system
Dis. Model. Mech.
1
229-240
2008
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8)
Ying, S.; Dong, S.; Kawada, A.; Kojima, T.; Chavanas, S.; Mechin, M.C.; Adoue, V.; Serre, G.; Simon, M.; Takahara, H.
Transcriptional regulation of peptidylarginine deiminase expression in human keratinocytes
J. Dermatol. Sci.
53
2-9
2009
Homo sapiens (Q6TGC4), Homo sapiens (Q9ULC6), Homo sapiens (Q9ULW8), Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
Proost, P.; Loos, T.; Mortier, A.; Schutyser, E.; Gouwy, M.; Noppen, S.; Dillen, C.; Ronsse, I.; Conings, R.; Struyf, S.; Opdenakker, G.; Maudgal, P.C.; Van Damme, J.
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation
J. Exp. Med.
205
2085-2097
2008
Oryctolagus cuniculus, Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8)
Li, P.; Yao, H.; Zhang, Z.; Li, M.; Luo, Y.; Thompson, P.R.; Gilmour, D.S.; Wang, Y.
Regulation of p53 target gene expression by peptidylarginine deiminase 4
Mol. Cell. Biol.
28
4745-4758
2008
Homo sapiens (Q9UM07)
Abdeen, S.M.; Olusi, S.O.
Peptidyl arginine deiminase: A novel immunohistochemical marker for liver fibrosis in patients with chronic hepatitis
Acta Histochem.
112
592-603
2010
Homo sapiens
Knuckley, B.; Causey, C.P.; Jones, J.E.; Bhatia, M.; Dreyton, C.J.; Osborne, T.C.; Takahara, H.; Thompson, P.R.
Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3
Biochemistry
49
4852-4863
2010
Homo sapiens
Knuckley, B.; Causey, C.P.; Pellechia, P.J.; Cook, P.F.; Thompson, P.R.
Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation
ChemBioChem
11
161-165
2010
Homo sapiens
Jones, J.E.; Causey, C.P.; Knuckley, B.; Slack-Noyes, J.L.; Thompson, P.R.
Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential
Curr. Opin. Drug Discov. Devel.
12
616-627
2009
Homo sapiens
Jang, B.; Jeon, Y.C.; Choi, J.K.; Park, M.; Kim, J.I.; Ishigami, A.; Maruyama, N.; Carp, R.I.; Kim, Y.S.; Choi, E.K.
Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases
Biochem. J.
445
183-192
2012
Oryctolagus cuniculus, Homo sapiens
Slack, J.L.; Jones, L.E.; Bhatia, M.M.; Thompson, P.R.
Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity
Biochemistry
50
3997-4010
2011
Homo sapiens
Rose, R.; Rose, M.; Ottmann, C.
Identification and structural characterization of two 14-3-3 binding sites in the human peptidylarginine deiminase type VI
J. Struct. Biol.
180
65-72
2012
Homo sapiens
Liu, Y.L.; Chiang, Y.H.; Liu, G.Y.; Hung, H.C.
Functional role of dimerization of human peptidylarginine deiminase 4 (PAD4)
PLoS ONE
6
e21314
2011
Homo sapiens
Unno, M.; Kizawa, K.; Ishihara, M.; Takahara, H.
Crystallization and preliminary X-ray crystallographic analysis of human peptidylarginine deiminase type III
Acta Crystallogr. Sect. F
68
668-670
2012
Homo sapiens (Q9ULW8), Homo sapiens
Unno, M.; Kinjo, S.; Kizawa, K.; Takahara, H.
Crystallization and preliminary X-ray crystallographic analysis of human peptidylarginine deiminase type I
Acta Crystallogr. Sect. F
69
1357-1359
2013
Homo sapiens (Q9ULC6), Homo sapiens
Darrah, E.; Rosen, A.; Giles, J.; Andrade, F.
Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: Novel insights into autoantigen selection in rheumatoid arthritis
Ann. Rheum. Dis.
71
92-98
2012
Homo sapiens (Q9ULW8), Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
Dreyton, C.J.; Knuckley, B.; Jones, J.E.; Lewallen, D.M.; Thompson, P.R.
Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism
Biochemistry
53
4426-4433
2014
Homo sapiens (Q9Y2J8)
Assohou-Luty, C.; Raijmakers, R.; Benckhuijsen, W.E.; Stammen-Vogelzangs, J.; de Ru, A.; van Veelen, P.A.; Franken, K.L.; Drijfhout, J.W.; Pruijn, G.J.
The human peptidylarginine deiminases type 2 and type 4 have distinct substrate specificities
Biochim. Biophys. Acta
1844
829-836
2014
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8)
Bozdag, M.; Dreker, T.; Henry, C.; Tosco, P.; Vallaro, M.; Fruttero, R.; Scozzafava, A.; Carta, F.; Supuran, C.T.
Novel small molecule protein arginine deiminase 4 (PAD4) inhibitors
Bioorg. Med. Chem. Lett.
23
715-719
2013
Homo sapiens (Q9UM07)
Jamali, H.; Khan, H.A.; Stringer, J.R.; Chowdhury, S.; Ellman, J.A.
Identification of multiple structurally distinct, nonpeptidic small molecule inhibitors of protein arginine deiminase 3 using a substrate-based fragment method
J. Am. Chem. Soc.
137
3616-3621
2015
Homo sapiens (Q9ULW8)
Subramanian, V.; Knight, J.S.; Parelkar, S.; Anguish, L.; Coonrod, S.A.; Kaplan, M.J.; Thompson, P.R.
Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors
J. Med. Chem.
58
1337-1344
2015
Homo sapiens (Q9ULC6), Homo sapiens (Q9ULW8), Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
Slade, D.J.; Fang, P.; Dreyton, C.J.; Zhang, Y.; Fuhrmann, J.; Rempel, D.; Bax, B.D.; Coonrod, S.A.; Lewis, H.D.; Guo, M.; Gross, M.L.; Thompson, P.R.
Protein arginine deiminase 2 binds calcium in an ordered fashion implications for inhibitor design
ACS Chem. Biol.
10
1043-1053
2015
Homo sapiens (Q9Y2J8)
Jamali, H.; Khan, H.A.; Tjin, C.C.; Ellman, J.A.
Cellular activity of new small molecule protein arginine deiminase 3 (PAD3) inhibitors
ACS Med. Chem. Lett.
7
847-851
2016
Homo sapiens (Q9ULW8), Homo sapiens
Kunieda, K.; Kawaguchi, M.; Ieda, N.; Nakagawa, H.
Development of a highly sensitive fluorescence probe for peptidyl arginine deiminase (PAD) activity
Bioorg. Med. Chem. Lett.
29
923-928
2019
Homo sapiens (Q9UM07)
Teo, C.Y.; Tejo, B.A.; Leow, A.T.C.; Salleh, A.B.; Abdul Rahman, M.B.
Novel furan-containing peptide-based inhibitors of protein arginine deiminase type IV (PAD4)
Chem. Biol. Drug Des.
90
1134-1146
2017
Homo sapiens (Q9UM07)
Olson, J.S.; Lubner, J.M.; Meyer, D.J.; Grant, J.E.
An in silico analysis of primary and secondary structure specificity determinants for human peptidylarginine deiminase types 2 and 4
Comput. Biol. Chem.
70
107-115
2017
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
Zhou, Y.; Mittereder, N.; Sims, G.
Perspective on protein arginine deiminase activity-bicarbonate is a pH-independent regulator of citrullination
Front. Immunol.
9
34
2018
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8)
Trabocchi, A.; Pala, N.; Krimmelbein, I.; Menchi, G.; Guarna, A.; Sechi, M.; Dreker, T.; Scozzafava, A.; Supuran, C.; Carta, F.
Peptidomimetics as protein arginine deiminase 4 (PAD4) inhibitors
J. Enzyme Inhib. Med. Chem.
30
466-471
2015
Homo sapiens (Q9UM07)
Damgaard, D.; Bjorn, M.E.; Jensen, P.O.; Nielsen, C.H.
Reactive oxygen species inhibit catalytic activity of peptidylarginine deiminase
J. Enzyme Inhib. Med. Chem.
32
1203-1208
2017
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
Subramanian, V.; Knight, J.S.; Parelkar, S.; Anguish, L.; Coonrod, S.A.; Kaplan, M.J.; Thompson, P.R.
Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors
J. Med. Chem.
58
1337-1344
2015
Homo sapiens (Q9UM07), Homo sapiens (Q9Y2J8), Homo sapiens
Saijo, S.; Nagai, A.; Kinjo, S.; Mashimo, R.; Akimoto, M.; Kizawa, K.; Yabe-Wada, T.; Shimizu, N.; Takahara, H.; Unno, M.
Monomeric form of peptidylarginine deiminase type I revealed by X-ray crystallography and small-angle X-ray scattering
J. Mol. Biol.
428
3058-3073
2016
Homo sapiens (Q9ULC6), Homo sapiens
