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Literature summary for 3.5.3.15 extracted from
- Perspective on protein arginine deiminase activity-bicarbonate is a pH-independent regulator of citrullination (2018), Front. Immunol., 9, 34 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| hydrogen carbonate | physiological levels of hydrogen carbonate upregulate citrullination by recombinant PAD2/4 and endogenous PADs in neutrophils. The impact of hydrogen carbonate is independent of calcium and pH | Homo sapiens |  |
Application
| Application | Comment | Organism |
|---|---|---|
| analysis | adding bicarbonate to commercial peptidyl arginine deiminase activity kits could increase assay performance and biological relevance | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q9UM07 | - |
- |
| Homo sapiens | Q9Y2J8 | - |
- |
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Release 2023.1 (January 2023)
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