Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | peptidylarginine deiminase 2 is activated only when sufficient Ca2+ is available (0.01 mM/l), at high concentrations that are normally not present in living cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9Y2J8 | peptidylarginine deiminase 2, patients with rheumatoid arthitis and healthy controls | - |
Homo sapiens | Q9Y2J8 | peptidylarginine deiminase 4, patients with rheumatoid arthitis and healthy controls | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
macrophage | peptidylarginine deiminase 2, cell from patients with rheumatoid arthitis and healthy controls show identical expression patterns | Homo sapiens | - |
monocyte | peptidylarginine deiminase 2, cell from patients with rheumatoid arthitis and healthy controls show identical expression patterns | Homo sapiens | - |
monocyte | peptidylarginine deiminase 4, cell from patients with rheumatoid arthitis and healthy controls show identical expression patterns | Homo sapiens | - |
additional information | no activity in macrophages | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
vimetin L-arginine + H2O | peptidylarginine deiminase 2 | Homo sapiens | vimentin L-citrulline + NH3 | - |
? | |
vimetin L-arginine + H2O | peptidylarginine deiminase 4 | Homo sapiens | vimentin L-citrulline + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAD2 | - |
Homo sapiens |
PAD4 | - |
Homo sapiens |
peptidylarginine deiminase 2 | - |
Homo sapiens |
peptidylarginine deiminase 4 | - |
Homo sapiens |