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Literature summary for 3.5.3.15 extracted from

  • Darrah, E.; Rosen, A.; Giles, J.; Andrade, F.
    Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: Novel insights into autoantigen selection in rheumatoid arthritis (2012), Ann. Rheum. Dis., 71, 92-98.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.3.15

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein L-arginine + H2O Homo sapiens
-
 protein L-citrulline + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9ULW8
-
-
Homo sapiens Q9UM07
-
-
Homo sapiens Q9Y2J8
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HL-60 cell
-
 Homo sapiens
-
neutrophil
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
beta-actin L-arginine + H2O substrate for isoform PAD2 only Homo sapiens beta-actin L-citrulline + NH3
-
 ?
citrullinated histone H3 L-arginine + H2O substrate for isoform PAD4 only Homo sapiens ?
-
 ?
gamma-actin L-arginine + H2O substrate for isoform PAD2 only Homo sapiens gamma-actin L-citrulline + NH3
-
 ?
protein L-arginine + H2O
-
 Homo sapiens protein L-citrulline + NH3
-
 ?

Synonyms

Synonyms Comment Organism
PAD2 isoform Homo sapiens
PAD3 isoform Homo sapiens
PAD4 isoform Homo sapiens
peptidylarginine deiminase
-
 Homo sapiens