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Literature summary for 3.5.3.15 extracted from

  • Li, P.; Yao, H.; Zhang, Z.; Li, M.; Luo, Y.; Thompson, P.R.; Gilmour, D.S.; Wang, Y.
    Regulation of p53 target gene expression by peptidylarginine deiminase 4 (2008), Mol. Cell. Biol., 28, 4745-4758.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli strain BL21, HEK-293T, and MCF-7 cell lines Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Cl-amidine inhibits PAD4 by covalent modification Cys-645 at the active site of the enzyme, Cl-amidine inhibits more than 50% of the PAD4 activity at the 0.05 mM concentration, whereas over 90% inhibition is reached with 0.2 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9UM07
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3-L-arginine + H2O PAD4 interacts with p53 and is recruited to the p21 promoter to regulate histone H3 L-Arg methylation and citrullination Homo sapiens histone H3-L-citrulline + NH3
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Synonyms

Synonyms Comment Organism
PAD4
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Homo sapiens
peptidylarginine deiminase 4
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Homo sapiens