Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli strain BL21, HEK-293T, and MCF-7 cell lines | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Cl-amidine | inhibits PAD4 by covalent modification Cys-645 at the active site of the enzyme, Cl-amidine inhibits more than 50% of the PAD4 activity at the 0.05 mM concentration, whereas over 90% inhibition is reached with 0.2 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9UM07 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3-L-arginine + H2O | PAD4 interacts with p53 and is recruited to the p21 promoter to regulate histone H3 L-Arg methylation and citrullination | Homo sapiens | histone H3-L-citrulline + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAD4 | - |
Homo sapiens |
peptidylarginine deiminase 4 | - |
Homo sapiens |