Cloned (Comment) | Organism |
---|---|
hPADI2 is expressed in Escherichia coli | Homo sapiens |
hPADI4 is expressed in Escherichia coli | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.001 | - |
filaggrin | hPADI2 | Homo sapiens | |
0.013 | - |
fibrinogen | hPADI2 | Homo sapiens | |
0.055 | - |
fibrinogen | hPADI4 | Homo sapiens | |
0.064 | - |
filaggrin | hPADI4 | Homo sapiens | |
0.15 | - |
benzoyl-Arg-ethyl ester | pH 7.6, 37°C, hPADI2 expressed by baculovirus | Homo sapiens | |
0.16 | - |
benzoyl-Arg-NH2 | pH 7.6, 37°C, hPADI4 expressed in Escherichia coli | Homo sapiens | |
0.63 | - |
benzoyl-Arg-methyl ester | pH 7.6, 37°C, hPADI4 expressed in Escherichia coli | Homo sapiens | |
0.73 | - |
benzoyl-Arg-ethyl ester | pH 7.6, 37°C, hPADI2 expressed in Escherichia coli | Homo sapiens | |
0.77 | - |
benzoyl-Arg-methyl ester | pH 7.6, 37°C, hPADI2 expressed by baculovirus | Homo sapiens | |
0.91 | - |
benzoyl-Arg-ethyl ester | pH 7.6, 37°C, hPADI4 expressed in Escherichia coli | Homo sapiens | |
1.01 | - |
benzoyl-Arg-NH2 | pH 7.6, 37°C, hPADI2 expressed in Escherichia coli | Homo sapiens | |
1.23 | - |
benzoyl-Arg-NH2 | pH 7.6, 37°C, hPADI2 expressed by baculovirus | Homo sapiens | |
1.63 | - |
tosyl-Arg-ethyl ester | pH 7.6, 37°C, hPADI2 expressed by baculovirus | Homo sapiens | |
1.97 | - |
benzoyl-Arg-methyl ester | pH 7.6, 37°C, hPADI2 expressed in Escherichia coli | Homo sapiens | |
5.61 | - |
tosyl-Arg-ethyl ester | pH 7.6, 37°C, hPADI2 expressed in Escherichia coli | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | hPADI2 | Homo sapiens | 5737 | - |
cytoplasm | hPADI4 | Homo sapiens | 5737 | - |
nucleus | hPADI4 | Homo sapiens | 5634 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | increase activity of hPADI4. 50% of maximal activity at 0.75 mM | Homo sapiens | |
Ca2+ | increases activity of hPADI2. 50% of maximal activity at 0.62 mM | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
rheumatoid arthritis patients | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
synovium | hPADI2 | Homo sapiens | - |
synovium | hPADI4 | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzoyl-Arg-ethyl ester + H2O | hPADI2 | Homo sapiens | benzoyl-citrulline-ethyl ester + NH3 | - |
? | |
benzoyl-Arg-ethyl ester + H2O | hPADI4 | Homo sapiens | benzoyl-citrulline-ethyl ester + NH3 | - |
? | |
benzoyl-Arg-methyl ester + H2O | hPADI2 | Homo sapiens | benzoyl-citrulline-methyl ester + NH3 | - |
? | |
benzoyl-Arg-methyl ester + H2O | hPADI4 | Homo sapiens | benzoyl-citrulline-methyl ester + NH3 | - |
? | |
benzoyl-Arg-NH2 + H2O | hPADI2 | Homo sapiens | benzoyl-citrulline-NH2 + NH3 | - |
? | |
benzoyl-Arg-NH2 + H2O | hPADI4 | Homo sapiens | benzoyl-citrulline-NH2 + NH3 | - |
? | |
Fibrinogen + H2O | human fibrinogen, hPADI2 | Homo sapiens | ? | - |
? | |
Fibrinogen + H2O | human fibrinogen, hPADI4 | Homo sapiens | ? | - |
? | |
filaggrin + H2O | human filaggrin, hPADI2 | Homo sapiens | ? | - |
? | |
filaggrin + H2O | human filaggrin, hPADI4 | Homo sapiens | ? | - |
? | |
tosyl-Arg-ethyl ester + H2O | hPADI2 | Homo sapiens | tosyl-citrulline-ethyl ester + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
hPADI2 | - |
Homo sapiens |
hPADI4 | - |
Homo sapiens |
peptidylarginine deiminase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
hPADI2 | Homo sapiens |
7.5 | - |
hPADI4 | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 10 | pH 6.0: about 75% of maximal activity, pH 10.0: about 50% of maximal activity, hPADI2 | Homo sapiens |
6.5 | 9 | pH 6.5: about 70% of maximal activity, pH 9.0: about 50% of maximal activity, hPADI4 | Homo sapiens |