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Literature summary for 3.5.3.15 extracted from

  • Nakayama-Hamada, M.; Suzuki, A.; Kubota, K.; Takazawa, T.; Ohsaka, M.; Kawaida, R.; Ono, M.; Kasuya, A.; Furukawa, H.; Yamada, R.; Yamamoto, K.
    Comparison of enzymatic properties between hPADI2 and hPADI4 (2005), Biochem. Biophys. Res. Commun., 327, 192-200.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
hPADI2 is expressed in Escherichia coli Homo sapiens
hPADI4 is expressed in Escherichia coli Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.001
-
filaggrin hPADI2 Homo sapiens
0.013
-
fibrinogen hPADI2 Homo sapiens
0.055
-
fibrinogen hPADI4 Homo sapiens
0.064
-
filaggrin hPADI4 Homo sapiens
0.15
-
benzoyl-Arg-ethyl ester pH 7.6, 37°C, hPADI2 expressed by baculovirus Homo sapiens
0.16
-
benzoyl-Arg-NH2 pH 7.6, 37°C, hPADI4 expressed in Escherichia coli Homo sapiens
0.63
-
benzoyl-Arg-methyl ester pH 7.6, 37°C, hPADI4 expressed in Escherichia coli Homo sapiens
0.73
-
benzoyl-Arg-ethyl ester pH 7.6, 37°C, hPADI2 expressed in Escherichia coli Homo sapiens
0.77
-
benzoyl-Arg-methyl ester pH 7.6, 37°C, hPADI2 expressed by baculovirus Homo sapiens
0.91
-
benzoyl-Arg-ethyl ester pH 7.6, 37°C, hPADI4 expressed in Escherichia coli Homo sapiens
1.01
-
benzoyl-Arg-NH2 pH 7.6, 37°C, hPADI2 expressed in Escherichia coli Homo sapiens
1.23
-
benzoyl-Arg-NH2 pH 7.6, 37°C, hPADI2 expressed by baculovirus Homo sapiens
1.63
-
tosyl-Arg-ethyl ester pH 7.6, 37°C, hPADI2 expressed by baculovirus Homo sapiens
1.97
-
benzoyl-Arg-methyl ester pH 7.6, 37°C, hPADI2 expressed in Escherichia coli Homo sapiens
5.61
-
tosyl-Arg-ethyl ester pH 7.6, 37°C, hPADI2 expressed in Escherichia coli Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm hPADI2 Homo sapiens 5737
-
cytoplasm hPADI4 Homo sapiens 5737
-
nucleus hPADI4 Homo sapiens 5634
-

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ increase activity of hPADI4. 50% of maximal activity at 0.75 mM Homo sapiens
Ca2+ increases activity of hPADI2. 50% of maximal activity at 0.62 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
rheumatoid arthritis patients
-

Source Tissue

Source Tissue Comment Organism Textmining
synovium hPADI2 Homo sapiens
-
synovium hPADI4 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
benzoyl-Arg-ethyl ester + H2O hPADI2 Homo sapiens benzoyl-citrulline-ethyl ester + NH3
-
?
benzoyl-Arg-ethyl ester + H2O hPADI4 Homo sapiens benzoyl-citrulline-ethyl ester + NH3
-
?
benzoyl-Arg-methyl ester + H2O hPADI2 Homo sapiens benzoyl-citrulline-methyl ester + NH3
-
?
benzoyl-Arg-methyl ester + H2O hPADI4 Homo sapiens benzoyl-citrulline-methyl ester + NH3
-
?
benzoyl-Arg-NH2 + H2O hPADI2 Homo sapiens benzoyl-citrulline-NH2 + NH3
-
?
benzoyl-Arg-NH2 + H2O hPADI4 Homo sapiens benzoyl-citrulline-NH2 + NH3
-
?
Fibrinogen + H2O human fibrinogen, hPADI2 Homo sapiens ?
-
?
Fibrinogen + H2O human fibrinogen, hPADI4 Homo sapiens ?
-
?
filaggrin + H2O human filaggrin, hPADI2 Homo sapiens ?
-
?
filaggrin + H2O human filaggrin, hPADI4 Homo sapiens ?
-
?
tosyl-Arg-ethyl ester + H2O hPADI2 Homo sapiens tosyl-citrulline-ethyl ester + NH3
-
?

Synonyms

Synonyms Comment Organism
hPADI2
-
Homo sapiens
hPADI4
-
Homo sapiens
peptidylarginine deiminase
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
hPADI2 Homo sapiens
7.5
-
hPADI4 Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6 10 pH 6.0: about 75% of maximal activity, pH 10.0: about 50% of maximal activity, hPADI2 Homo sapiens
6.5 9 pH 6.5: about 70% of maximal activity, pH 9.0: about 50% of maximal activity, hPADI4 Homo sapiens