Literature summary for 3.5.3.15 extracted from

Sambandam, T.; Belousova, M.; Accaviti-Loper, M.A.; Blanquicett, C.; Guercello, V.; Raijmakers, R.; Nicholas, A.P.
Increased peptidylarginine deiminase type II in hypoxic astrocytes (2004), Biochem. Biophys. Res. Commun., 325, 1324-1329.

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	activity is increased by hypoxic conditions	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
glial fibrillary acidic protein L-arginine + H2O	Homo sapiens	-	glial fibrillary acidic protein L-citrulline + NH3	-	?
protein L-Arg + H2O	Homo sapiens	peptidyl deiminase type II is the primary enzyme responsible for the conversion of protein bound arginine to citrulline in the central nervous system	protein L-citrulline + NH3	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y2J8	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
astrocyte	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glial fibrillary acidic protein L-arginine + H2O	-	Homo sapiens	glial fibrillary acidic protein L-citrulline + NH3	-	?
protein L-Arg + H2O	peptidyl deiminase type II is the primary enzyme responsible for the conversion of protein bound arginine to citrulline in the central nervous system	Homo sapiens	protein L-citrulline + NH3	-	?

Synonyms

Synonyms	Comment	Organism
PAD 2	-	Homo sapiens
peptidylarginine deiminase type II	-	Homo sapiens

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Release 2023.1 (January 2023)