Information on EC - factor-independent urate hydroxylase

for references in articles please use BRENDA:EC1.7.3.3
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EC Tree
IUBMB Comments
This enzyme was previously thought to be a copper protein, but it is now known that the enzymes from soy bean (Glycine max), the mould Aspergillus flavus and Bacillus subtilis contains no copper nor any other transition-metal ion. The 5-hydroxyisourate formed decomposes spontaneously to form allantoin and CO2, although there is an enzyme-catalysed pathway in which EC, hydroxyisourate hydrolase, catalyses the first step. The enzyme is different from EC (FAD-dependent urate hydroxylase).
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Word Map
The enzyme appears in viruses and cellular organisms
Reaction Schemes
uricase, rasburicase, urate oxidase, uricase ii, uric acid oxidase, uricozyme, aguox, nodulin 35, elitek, fasturtec, more
urate + O2 + H2O = 5-hydroxyisourate + H2O2
show the reaction diagram